Selected Publications

2012

2011

2010

2009

2008

2007

2006

2005

2004

2003

2002

2001

2000

1999 & Earlier

2012

1. Singh, A. Na, C., Silva, L.C., Prieto, M., Futerman, A.H., Luberto, C. and Del Poeta, M. (2012)
   Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans.
   Cellular Microbiology
2. Tidhar, R., Ben-Dor, S., Wang, E., Kelly, S., Merrill, A.H. Jr. and Futerman, A.H. (2012)
   The acyl chain specificity of ceramide synthases is determined within a region of 150 residues in the Tram-Lag-CLN8 (TLC) domain.
   J. of Biol. Chem.
3. Vitner, E.B., Biton, I., Farfel-Becker, T. and Futerman, A.H.(2012)
   Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher disease.
4. Silva, L.C., Ben-David, O., Pewzner-Jung, Y., Laviad, E.L., Stiban, J., Bandyopadhyay, S., Merrill, A.H. Jr., Prieto, M. and Futerman, A.H.(2012)
   Ablation of Ceramide Synthase 2 strongly affects biophysical properties of membranes.
   J. of Lipid Research

2011

1. Farfel-Becker, T., Vitner, E.B. and Futerman. A.H. (2011)
   Animal models for Gaucher disease research.
   Dis Model Mech. 2011 November; 4(6): 746–752.
2. Yurlova, L., Kahya, N., Aggarwal, S., Kaiser, H-J., Chiantia, S., Bakhti, M., Pewzner-Jung, Y., Ben-David, O., Futerman, A.H., Brügger, B. and Simons, M.(2011)
   Self-organization of myelin membrane lipids in model membranes.
   Biophysical Journal 101(11):7 Dec 2011,2713-2720.
3. Farfel-Becker T, Vitner EB, Pressey SN, Eilam R, Cooper JD, Futerman AH.
   Spatial and temporal correlation between neuron loss and neuroinflammation in a mouse model of neuronopathic Gaucher disease.
   Hum Mol Genet.. 2011 Apr 1;20(7):1375-86. Epub 2011 Jan 20.
4. Goldschmidt-Arzi M, Shimoni E, Sabanay H, Futerman AH, Addadi L.
   Intracellular localization of organized lipid domains of C16-ceramide/cholesterol.
   J Struct Biol. 2011 Jul;175(1):21-30.

5. Brumshtein B, Aguilar-Moncayo M, Benito JM, García Fernandez JM, Silman I, Shaaltiel Y, Aviezer D, Sussman JL, Futerman AH, Ortiz Mellet C.
   Cyclodextrin-mediated crystallization of acid ß-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues.
   Org Biomol Chem. 2011 Jun 7;9(11):4160-7.

6. Shachar T, Bianco CL, Recchia A, Wiessner C, Raas-Rothschild A, Futerman AH.
   Lysosomal storage disorders and Parkinson's disease: Gaucher disease and beyond.
   Mov Disord. 2011 May 26
   doi: 10.1002/mds.23774. [Epub ahead of print]

7. Ben-David O, Pewzner-Jung Y, Brenner O, Laviad EL, Kogot-Levin A, Weissberg I, Biton IE, Pienik R, Wang E, Kelly S, Alroy J, Raas-Rothschild A, Friedman A, Brugger B, Merrill AH Jr, Futerman AH.
   Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels.
   J Biol Chem. 2011 Aug 26;286(34):30022-33. Epub 2011 Jun 24.

8. Offman MN, Krol M, Rost B, Silman I, Sussman JL, Futerman AH.
   Comparison of a molecular dynamics model with the X-ray structure of the N370S acid-{beta}-glucosidase mutant that causes Gaucher disease.
   Protein Eng Des Sel. 2011 Jul 1. [Epub ahead of print]

9. Pinto SN, Silva LC, Futerman AH, Prieto M.
   Effect of ceramide structure on membrane biophysical properties: The role of acyl chain length and unsaturation.
   Biochim Biophys Acta. 2011 Jul 30. [Epub ahead of print]

2010

1. Vitner EB, Dekel H, Zigdon H, Shachar T, Farfel-Becker T, Eilam R, Karlsson S, Futerman AH. (2010)
   Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidoses.
   Hum Mol Genet.Sep 15;19(18):3583-90. Epub 2010 Jul 8.

2. Offman MN, Krol M, Silman I, Sussman JL, Futerman AH.
   Molecular basis of reduced glucosylceramidase activity in the most common Gaucher disease mutant, N370S.
   J Biol Chem. 2010 Dec 31;285(53):42105-14. Epub 2010 Oct 27.

3. Futerman AH, Schuldiner M. (2010)
   Lipids: The plasma membrane code.
   Nat Chem Biol. 2010 Jul;6(7):487-8.

4. Ben-David O, Futerman AH. (2010)
   The Role of the Ceramide Acyl Chain Length in Neurodegeneration: Involvement of Ceramide Synthases.
   Neuromolecular Med. 2010 May 26.

5. Vitner EB, Platt FM, Futerman AH. (2010)
   Common and uncommon pathogenic cascades in lysosomal storage diseases.
   J Biol Chem. 2010 Jul 2;285(27):20423-7.

6. Levy M, Futerman AH. (2010)
   Mammalian ceramide synthases.
   IUBMB Life 2010 May;62(5):347-56.

7. Erez-Roman R, Pienik R, Futerman AH. (2010)
   Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.
   Biochem Biophys Res Commun. 2010 Jan 1;391(1):219-23. Epub 2009 Nov 11.

8. Pewzner-Jung Y, Park H, Laviad EL, Silva LC, Lahiri S, Stiban J, Erez-Roman R, Brugger B, Sachsenheimer T, Wieland F, Prieto M, Merrill AH Jr, Futerman AH. (2010)
   A critical role for ceramide synthase 2 in liver homeostasis: I. Alterations in lipid metabolic pathways.
   J Biol Chem. 2010 Jan 28. [Epub ahead of print]

9. Pewzner-Jung Y, Brenner O, Braun S, Laviad EL, Ben-Dor S, Feldmesser E, Horn-Saban S, Amann-Zalcenstein D, Raanan C, Berkutzki T, Erez-Roman R, Ben David O, Levy M, Holzman D, Park H, Nyska A, Merrill AH Jr, Futerman AH. (2010)
   A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy.
   J Biol Chem. 2010 Jan 28. [Epub ahead of print]

2009

1. Silva, L.C., Futerman, A.H. and Prieto, M. (2009)
   Lipid raft composition modulates sphingomyelinase activity and ceramide-induced membrane physical alterations.
   Biophys. J., 2009 Apr 22;96(8):3210-22.

2. Sridevi, P., Alexander, H., Laviad, E., Pewzner-Jung, Y., Hannink, M., Futerman, A.H. and Alexander, S. (2009)
   Ceramide Synthase 1 is regulated by proteasomal mediated turnover.
   Biochim. Biophys. Acta., April 22.

3. Kacher, Y. and Futerman, A.H. (2009)
   Impaired IL-10 transcription and release in animal models of Gaucher disease macrophages.
   Blood Cells Mol. Dis., 2009 Apr 18.

4. Brumshtein, B., Aguilar, M., García-Moreno, M.I., Ortiz Mellet, C., García Fernandez, J.M., Silman, I., Shaaltiel, Y., Aviezer, D., Sussman, J.L. and Futerman, A.H. (2009)
   6-Amino-6-deoxy-5,6-di-N-(N’-octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation and Crystal Structure in Complex with Acid b-Glucosidase.
   ChemBioChem., 2009 May 13.

5. Goldfinger, M., Laviad, E.L., Hadar, R., Shmuel, M., Dagan, A., Park, H., Merrill, A.H., Ringel, I., Futerman, A.H. and Tirosh, B. (2009)
   De novo ceramide synthesis is required for N-linked glycosylation in plasma cells.
   J. Immunol., 2009 Jun 1;182(11):7038-47.

6. Stiban, J., Tidhar, R., and Futerman, A.H. (2009)
   Ceramide Synthases: Roles in Cell Physiology and Signaling In 'Sphingolipids as Signaling and Regulatory Molecules'. (Eds: C. Chalfant and M. Del Poeta).
   Landes Bioscience, Georgetown, TX., in press

7. Farfel-Becker T, Vitner E, Dekel H, Leshem N, Enquist IB, Karlsson S, Futerman AH. (2009)
   No evidence for activation of the unfolded protein response in neuronopathic models of Gaucher disease.
   Hum. Mol. Genet. Apr 15;18(8):1482-8. Epub 2009 Feb 3.

8. Lahiri S, Park H, Laviad EL, Lu X, Bittman R, Futerman AH. (2009)
   Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and non-competitive inhibition in an acyl coa chain length-dependent manner.
   J Biol. Chem. 2009 Apr 8.

9. Brumshtein B, Salinas P, Peterson B, Chan V, Silman I, Sussman JL, Savickas PJ, Robinson GS, Futerman AH.
   Characterization of gene-activated human acid-beta-glucosidase: crystal structure, glycan composition, and internalization into macrophages.
   Glycobiology. 2010 Jan;20(1):24-32. Epub 2009 Sep 9.

10. Sridevi P, Alexander H, Laviad EL, Min J, Mesika A, Hannink M, Futerman AH, Alexander S.
    Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing.
    Exp. Cell Res. 2010 Jan 1;316(1):78-91. Epub 2009 Oct 2.

2008

1. Stiban, J., Silva, L.C. and Futerman, A.H. (2008)
   Ceramide-containing membranes: the interface between biophysics and biology.
   Trends Glycosci. Glycotechnol. (Japan), 20, 297-313.

2. Brumshtein, B., Greenblatt, H.M., Futerman, A.H., Silman, I. and Sussman, J.L. (2008)
   Control of the rate of evaporation in protein crystallization by the 'microbatch under oil' method.
   J. Applied Crystallog., 41, 969-971.

3. Kacher Y, Brumshtein B, Boldin-Adamsky S, Toker L, Shainskaya A, Silman I, Sussman JL, Futerman AH. (2008)
   Acid-beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy.
   Biol Chem. 2008 Nov: 389(11):1361-1369. Review.

4. Ginzburg L, Li SC, Li YT, Futerman AH.
   An exposed carboxyl group on sialic acid is essential for gangliosides to inhibit calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase: relevance to gangliosidoses.
   J. Neurochem. 2008 Jan;104(1):140-6.

5. Laviad EL, Albee L, Pankova-Kholmyansky I, Epstein S, Park H, Merrill AH Jr, Futerman AH. (2008)
   Characterization of ceramide synthase 2: Tissue distribution, substrate specificity and inhibition by sphingosine 1-phosphate.
   J. Biol. Chem. 283, 5677-5684..

2007

1. Scheffer L, Futerman AH, Addadi L.
   Antibody labeling of cholesterol/ceramide ordered domains in cell membranes.
   Chembiochem. 2007 Dec 17;8(18):2286-94.
   PMID: 17957818 [PubMed - in process]

2. Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, Futerman AH.
   Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.
   FEBS Lett. 2007 Nov 13;581(27):5289-94. Epub 2007 Oct 23.
   PMID: 17977534 [PubMed - in process]

3. Futerman AH.
   Cell biology: taxi service for lipids.
   Nature 2007 Sep 6;449(7158):35-7. No abstract available.
   PMID: 17805285 [PubMed - indexed for MEDLINE]

4. Shaaltiel Y, Bartfeld D, Hashmueli S, Baum G, Brill-Almon E, Galili G, Dym O, Boldin-Adamsky SA, Silman I, Sussman JL, Futerman AH, Aviezer D.
   Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system.
   Plant Biotechnol J. 2007 Sep;5(5):579-90. Epub 2007 May 24.

5. Lahiri S, Futerman AH.
   The metabolism and function of sphingolipids and glycosphingolipids.
   Cell Mol Life Sci. 2007 Sep;64(17):2270-84.

6. Min J, Mesika A, Sivaguru M, Van Veldhoven PP, Alexander H, Futerman AH, Alexander S.
   (Dihydro)ceramide Synthase 1 Regulated Sensitivity to Cisplatin Is Associated with the Activation of p38 Mitogen-Activated Protein Kinase and Is Abrogated by Sphingosine Kinase 1.
   Mol Cancer Res. 2007 Aug;5(8):801-12.

7. Kacher Y, Golan A, Pewzner-Jung Y, Futerman AH.
   Changes in macrophage morphology in a Gaucher disease model are dependent on CTP:phosphocholine cytidylyltransferase alpha.
   Blood Cells Mol Dis. 2007 Jul-Aug;39(1):124-9.

8. Brumshtein B, Greenblatt HM, Butters TD, Shaaltiel Y, Aviezer D, Silman I, Futerman AH, Sussman JL.
   Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid-beta -glucosidase: Insights into the mechanism of chemical chaperone action in gaucher disease.
   J Biol Chem. 2007 Jul 31; [Epub ahead of print]

9. Mesika A, Ben-Dor S, Laviad EL, Futerman AH.
   A new functional motif in hox domain-containing ceramide synthases: identification of a novel region flanking the hox and TLC domains essential for activity.
   J Biol Chem. 2007 Jul 11; [Epub ahead of print]

2006

1. Brumshtein B, Wormald MR, Silman I, Futerman AH, Sussman JL.
   Structural comparison of differently glycosylated forms of acid-beta-glucosidase, the defective enzyme in Gaucher disease.
   Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1458-65.

2. Kacher Y, Futerman AH.
   Genetic diseases of sphingolipid metabolism: Pathological mechanisms and therapeutic options.
   FEBS Lett. 2006 Sep 1.

3. Pewzner-Jung Y, Ben-Dor S, Futerman A.H.
   When do Lasses (Longevity Assurance Genes) become CerS (Ceramide Synthases)? Insights into the regulation of ceramide synthesis.
   J Biol Chem., 2006 Sep 1;281(35):25001-5.

4. Futerman AH.
   Intracellular trafficking of sphingolipids: Relationship to biosynthesis.
   Biochim Biophys Acta. 2006 Aug 15.

5. Hillaert U, Boldin-Adamsky S, Rozenski J, Busson R, Futerman AH, Calenbergh SV.
   Synthesis and biological evaluation of novel PDMP analogues.
   Bioorg Med Chem., 2006 Aug 1;14(15):5273-84.

6. Kacher, Y., and Futerman, A.H.
   Neuronal cell death in the glycosphingolipidoses.
   Springer-Verlag, Tokyo.

7. Pankova-Kholmyansky, I., and Futerman, A.H.
   Ceramide synthase.
   In Sphingolipid Biology (Eds: Y. Hirabayashi, Y. Igarashi and A.H. Merrill), Springer-Verlag, Tokyo. 2006.

8. Arfi A, Zisling R, Richard E, Batista L, Poenaru L, Futerman AH, Caillaud C.
   Reversion of the biochemical defects in murine embryonic Sandhoff neurons using a bicistronic lentiviral vector encoding hexosaminidase alpha and beta.
   J. Neurochem., 2006 Mar;96(6):1572-9.

9. Futerman, A.H. and Zimran, A. (eds.) (2006).
   'Gaucher Disease.'
   CRC Press, Taylor and Francis Group, Boca Raton, FL.

10. Premkumar,L., Silman, I., Sussman, J.L., and Futerman, A.H. (2006)
    The X-ray structure of human acid-b-glucosidase: implications for second-generation enzyme replacement therapy.
    In: 'Gaucher Disease,' Eds: A.H. Futerman and A. Zimran, CRC Press, Taylor and Francis Group, Boca Raton, FL. pp. 85-96.

11. Futerman, A.H. (2006).
    Cellular pathology in Gaucher disease.
    In: 'Gaucher Disease,' Eds: A.H. Futerman and A. Zimran, CRC Press, Taylor and Francis Group, Boca Raton, FL., pp. 97-108.

2005

1. Ginzburg L, Futerman AH.
   Defective calcium homeostasis in the cerebellum in a mouse model of Niemann-Pick A disease.
   J Neurochem., 2005 Dec;95(6):1619-28.

2. Futerman AH.
   [Lysosomal storage diseases: pathological mechanisms and therapeutic options.]
   Med Sci (Paris). 2005 Dec;21(11 Suppl):16-9. French.

3. Lahiri, S. and Futerman, A.H
   Lass5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl CoA as acyl donor.
   J. Biol. Chem. 2005 Oct 7;280(40):33735-8.

4. Futerman AH, Riezman H.
   The ins and outs of sphingolipid synthesis.
   Trends Cell Biol.15(6):312-8. Review.

5. Premkumar, L., Sawkar, A.R., Boldin-Adamsky, S., Toker, L., Silman, I., Kelly, J., Futerman, A.H. & Sussman, J.L.
   X-ray structure of human acid-beta-glucosidase covalently-bound to conduritol b epoxide implications for gaucher disease
   J. Biol. Chem.,2005 Jun 24;280(25):23815-9.

6. Jmoudiak, M. and Futerman, A.H.
   Gaucher disease: pathological mechanisms and modern management.
   Br. J. Haematol.2005 Apr;129(2):178-88. Review.

7. Cohen, T., Auerbach, W., Ravid, L., Bodennec, J., Fein, A., Futerman, A.H., Joyner A.L., and Horowitz, M.
   The exon 8-containing prosaposin splice variant is dispensable for mouse development, lysosomal function and secretion.
   Mol. Cell. Biol., 2005 Mar;25(6):2431-40.

8. Futerman, A.H.
   Sphingolipid and Glycolipid Biology.
   In Encyclopedia of Molecular Cell Biology and Molecular Medicine, Second Edition, WILEY-VCH, Weinheim, Germany, 2005.

9. Pelled, D., Trajkovic-Bodennec, S., Lloyd-Evans, E., Sidransky, E., Schiffmann, S. and Futerman, A.H
   Enhanced calcium release in the acute neuronopathic form of Gaucher disease .
   Neurobiol. of Disease, 2005 Feb;18(1):83-8.

Back to top

2004

1. Buccoliero, R., Ginzburg, L., Futerman, A.H
   Elevation of lung surfactant phosphatidylcholine in mouse models of Sandhoff and of Niemann-Pick A disease.
   J. Inh. Met. Dis., 2004;27(5):641-8.

2. Ganor Y, Goldberg-Stern H, Amromd D, Lerman-Sagie T, Teichberg VI, Pelled D, Futerman AH, Zeev BB, Freilinger M, Verheulpen D, Van Bogaert P, Levite M.
   Autoimmune epilepsy: some epilepsy patients harbor autoantibodies to glutamate receptors and dsDNA on both sides of the blood-brain barrier, which may kill neurons and decrease in brain fluids after hemispherotomy.
   Clin. Dev. Immunol., 2004 Sep-Dec;11(3-4):241-52.

3. Futerman, A.H. and van Meer, G.
   When cells stash their trash.
   Nature Cell Biology 6, 1019. 2004. [Abstract]

4. Raas-Rothschild A., Pankova-Kholmyansky, I., Kacher, Y. and Futerman, A.H
   Glycosphingolipidoses: beyond the enzymatic defect.
   Glycoconjugate J., 2004;21(6):295-304. Review.

5. Futerman AH, Sussman JL, Horowitz M, Silman I, Zimran A.
   New directions in the treatment of Gaucher disease.
   Trends Pharmacol Sci., 2004 Mar;25(3):147-51. Review.

6. Futerman, A.H. and Hannun, Y.A
   The complex life of simple sphingolipids.
   EMBO Reps., 2004 Aug;5(8):777-82. Review.

7. Ginzburg, L., Kacher, Y. and Futerman, A.H
   The pathogenesis of glycosphingolipid storage disorders.
   Sem. Cell Develop. Biol., 2004 Aug;15(4):417-31. Review.

8. Trajkovic-Bodennec, S., Bodennec, J. and Futerman, A.H
   Phosphatidylcholine metabolism is altered in a monocyte-derived macrophage model of Gaucher disease but not in lymphocytes.
   Blood Cells, Molecules and Diseases, 2004 Jul-Aug;33(1):77-82.

9. Futerman AH, van Meer G.
   The cell biology of lysosomal storage disorders.
   Nat Rev Mol Cell Biol., 2004 Jul;5(7):554-65. Review.

10. Buccoliero, R., Bodennec, J., van Echten-Deckert, G., Sandhoff, K., and Futerman, A.H
    Phospholipid synthesis is decreased in neuronal tissuesin a mouse model of Sandhoff disease.
    J. Neurochem., 2004 Jul;90(1):80-8.

Back to top

2003

1. Lloyd-Evans E., Pelled, D., Riebeling, C. and Futerman, A.H
   Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms.
   Biochem. J ., 2003 Nov 1;375(Pt 3):561-5.

2. Riebeling, C., Allegood, J.C., Wang, E., Merrill, A.H. Jr., Futerman, A.H
   Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.
   J. Biol. Chem ., 2003 Oct 31;278(44):43452-9.

3. Pelled, D., Riebeling, C., van Echten-Deckert, G., Sandhoff, K., and Futerman, A.H.
   Reduced rates of axonal and dendritic growth in embryonic hippocampal neurones cultured from a mouse model of Sandhoff disease.
   Neuropathol. Applied Neurobiol ., 2003 Aug;29(4):341-9.

4. Pelled, D., Lloyd-Evans, E., Riebeling, C., Jeyakumar, M., Platt, F.M., and Futerman, A.H
   Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin.
   J. Biol. Chem., 2003 Aug 8;278(32):29496-501.

5. Dvir, H., Harel, M., McCarthy, A.H. Toker, L., Silman, I., Futerman, A.H. and Sussman, J.L
   X-ray structure of human acid glucosidase, the defective enzyme in gaucher disease ray structure of human acid glucosidase, the defective enzyme in gaucher disease.
   EMBO Rep., 2003 Jul;4(7):704-9.

6. Bodennec, J., Trajkovic-Bodennec, S. and Futerman, A.H
   Simultaneous quantification of lyso-neutral glycosphingolipids and neutral glycosphingolipids by N-acetylation with [3H]acetic anhydride.
   J. Lipid. Res., 2003 Jul;44(7):1413-9.

7. Buccoliero, R. and Futerman, A.H.
   The roles of ceramide and complex sphingolipids in neuronal cell function.
   Pharamacol. Res., 2003 May;47(5):409-19. Review.

8. Bodennec, J., Pelled, D., and Futerman, A.H.S
   Aminopropyl solid phase extraction and 2 D TLC of neutral glycosphingolipids and neutral lysoglycosphingolipids.
   J. Lipid Res., 2003 Jan;44(1):218-26.

9. Riebeling, C. and Futerman, A.H.
   Ceramide in the regulation of neuronal development: Two faces of a lipid. In: Ceramide signalling.
   Landes Bioscience, pp. 101-111. 2003. [Abstract]

10. Lloyd-Evans, E., Pelled, D., Riebeling, C., Bodennec, J., de-Morgan, A., Waller, H., Schiffmann, R., and Futerman, A.H.
    Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms.
    J. Biol. Chem., 2003 Jun 27;278(26):23594-9.

Back to top

2002

1. R., Funato, K., Venkataraman, K., Futerman, A.H. and Riezman, H.
   Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.
   J. Biol. Chem., 2002 Dec 20;277(51):49538-44.

2. Bodennec, J., Pelled, D., Riebeling, C., Trajkovic, S. and Futerman, A.H.
   Phosphatidylcholine synthesis is elevated in neuronal models of Gaucher disease due to direct activation of CTP:phosphocholine cytidylyltransferase by glucosylceramide.
   FASEB J., 2002 Nov;16(13):1814-6.

3. Futerman, A.H.
   Ceramide signaling.
   Landes Bioscience. 2002.

4. Venkataraman, K. and Futerman, A.H.
   Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis?
   FEBS Letts., 2002 Sep 25;528(1-3):3-4.

5. Venkataraman, K., Riebeling, C., Bodennec, J., Riezman, H., Allegood, J.C., Sullards, M.C., Merrill, A.H. Jr., and Futerman, A.H.
   Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells.
   J. Biol. Chem., 2002 Sep 20;277(38):35642-9.

6. Buccoliero, R., Bodennec, J., and Futerman, A.H
   The role of sphingolipids in neuronal development: Lessons from models of sphingolipid storage diseases.
   Neurochem. Res., 2002 Aug;27(7-8):565-74. Review.

7. Brann AB, Tcherpakov M, Williams IM, Futerman AH, Fainzilber M.
   Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase.
   J Biol Chem., 2002 Mar 22;277(12):9812-8.

8. De Jonghe, S., Lamote, I., Venkataraman, K., Boldin, S.A., Hillaert, U., Rozinski, R., Hendrix, C., Busson, R., De Keukeleire, D., Van Calenbergh, S., Futerman, A.H., and Herdewijn, P.
   Synthesis of homoceramides, novel ceramide analogues, and their lack of effect on the growth of hippocampal neurons.
   J. Org. Chem., 2002 Feb 8;67(3):988-96.

9. Pelled, D., Raveh, T., Riebeling, C., Fridkin, M., Berissi, H., Futerman, A.H. and Kimchi, A.
   Death-associated protein- (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons.
   J. Biol. Chem., 2002 Jan 18;277(3):1957-61.

Back to top

2001

1. Shogomori, H. and Futerman, A.H.
   Cholesterol depletion by methyl-beta-cyclodextrin blocks cholera toxin transport from endosomes to the Golgi apparatus in hippocampal neurons.
   J. Neurochem., 2001 Sep;78(5):991-9.

2. Shogomori, H. and Futerman, A.H.
   Cholera toxin is found in detergent-insoluble rafts/domains at the cell surface of hippocampal neurons but is internalized via a raft-independent mechanism.
   J. Biol. Chem., 2001 Mar 23;276(12):9182-8.

3. Venkataraman, K. and Futerman, A.H.
   Comparison of the metabolism of L-erythro- and L-threo-sphinganines and ceramides in cultured cells and in subcellular fractions.
   Biophys. Acta., 2001 Feb 26;1530(2-3):219-26.

Back to top

2000

1. Terstappen, G. Futerman, A.H., and Schwarz, A
   Cloud-point extraction of gangliosides using nonionic detergent C14EO6.
   Methods Enzymol., 2000;312:187-96.

2. Schwarz, A. and Futerman, A.H.
   Immunolocalization of gangliosides by light microscopy using anti-ganglioside antibodies.
   Methods Enzymol., 2000;312:179-87.

3. van Overmeire, I., Boldin. S.A., Venkataraman, K., Zisling, R., De Jonghe, S., van Calenbergh, S., De Keukeleire, D., Futerman, A.H., Herdewijn, P.
   Synthesis and biological evaluation of ceramide analogues with substituted aromatic rings or an allylic fluoride in the sphingoid part.
   J. Med. Chem., 2000 Nov 2;43(22):4189-99.

4. Venkataraman, K. and Futerman, A.H.
   Ceramide as a second messenger: sticky solutions to sticky problems.
   Trends Cell Biol., 2000 Oct;10(10):408-12. Review.

5. Boldin, S.A. and Futerman, A.H.
   Up-regulation of glucosylceramide synthesis upon stimulation of axonal growth by basic fibroblast growth factor: evidence for post-translational modification of glucosylceramide synthase.
   J. Biol. Chem., 2000 Apr 7;275(14):9905-9.

6. Neuberger, Y., Shogomori, H., Levy, Z., Fainzilber, M. and Futerman, A.H.
   A lyso-platelet activating factor phospholipase C, originally suggested to be a neutral-sphingomyelinase, is located in the endoplasmic reticulum.
   FEBS Letts., 2000 Mar 3;469(1):44-6.

7. Pelled, D., Shogomori, H., and Futerman, A.H.
   The increased sensitivity of neurons with elevated glucocerebroside to neurotoxic agents can be reversed by Imiglucerase.
   J. Inherit. Metab. Dis., 2000 Mar;23(2):175-84.

8. Schwarz, A., Jürgens, L., Licht, A., Schneider, H., Futerman, A.H. and Pecht, I.
   An IgE-dependent secretory response of mast cells can be induced by a glycosphingolipid-specific monoclonal antibody.
   Eur. J. Immunol., 2000 Jan;30(1):217-26.

Back to top

1999

1. Brann. A., Scott, R., Neuberger, Y., Abulafia, D., Boldin, S., Fainzilber, M., and Futerman, A.H.
   Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neurons.
   J. Neurosci., 1999 Oct 1;19(19):8199-206.

2. Shogomori, H., Burack, M.A., Banker, G. and Futerman, A.H.
   Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons.
   FEBS Letts., 1999 Sep 17;458(2):107-11.

3. Futerman, A.H., Boldin, S.A., Brann, A., Pelled, D., Meivar-Levy, I., and Zisling, R.
   Regulation of sphingolipid and glycosphingolipid metabolism during neuronal growth and development.
   Biochem. Soc. Trans., 1999 Aug;27(4):432-7. Review.

4. Levite, M., Fleidervich, I.A., Schwarz, A., Pelled, D., and Futerman, A.H.
   Autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel.
   J. Autoimmunity, 1999 Aug;13(1):61-72.

5. Korkotian, E., Schwarz, A., Pelled, D., Schwarzmann, G., Segal, M. and Futerman, A.H.
   Elevation of intracellular glucosylceramide levels results in an increase in endoplasmic reticulum density and in functional calcium stores in cultured neurons.
   J. Biol. Chem., 1999 Jul 30;274(31):21673-8.

6. van Overmeire, I., Boldin. S.A., Dumont, F., van Calenbergh, S., Slegers, G., De Keukeleire, D., Futerman, A.H., Herdewijn, P.
   Effect of aromatic short-chain analogues of ceramide on axonal growth in hippocampal neurons.
   J. Med. Chem., 1999 Jul 15;42(14):2697-705.

7. Naslavsky, N., Shmeeda, H., Friedlander, G., Yanai, A., Futerman, A.H., Barenholz, Y. and Taraboulos, A.
   Sphingolipid depletion increases formation of the scrapie prion protein in neuroblastoma cells infected with prions.
   J. Biol. Chem., 1999 Jul 23;274(30):20763-71.

8. Meivar-Levy, I. and Futerman, A.H.
   Up-regulation of neutral glycosphingolipid synthesis upon long-term inhibition of ceramide synthesis by fumonisin B1.
   J. Biol. Chem., 1999 Feb 19;274(8):4607-12.

Back to top

1998

1. Futerman AH, Ghidoni R, van Meer G.
   Lipids: regulatory functions in membrane traffic and cell development. Kfar Blum Kibbutz Guest House, Galilee, Israel, May 10-15, 1998.
   EMBO J., 1998 Dec 1;17(23):6772-5. Review.

2. Khanin, R., Segel, L., Futerman, A.H.
   The diffusion of molecules in axonal plasma membranes: the sites of insertion of new membrane molecules and their distribution along the axon surface.
   J. Theoret. Biol., 1998 Aug 7;193(3):371-82.

3. Futerman, A.H.
   Distinct roles for sphingolipids and glycosphingolipids at different stages of neuronal development.
   Acta Biochimica Polonica., 1998;45(2):469-78. Review.

4. Schwarz, A., and Futerman, A.H.
   Inhibition of sphingolipid synthesis, but not degradation, alters the rate of dendrite growth in cultured hippocampal neurons.
   Dev. Brain. Res., 1998 Jun 15;108(1-2):125-30.

5. Futerman, A.H., Boldin, S., Brann, A.B., Schwarz, A., and Zisling, R.
   Regulatory roles for sphingolipids in the growth of polarized neurons. In: Sphingolipids as signaling modulators in the nervous system. (Eds: Ledeen, R.W., Hakamori, S.-i., Yates, A.J., Schneider, J.S. and Yu, R.K.)
   Ann. New York Acad. Sci., 1998 Jun 19;845:176-87. Review.

6. Futerman, A.H.
   The roles of ceramide in the regulation of neuronal growth and development.
   Biochemistry (Moscow), 1998 Jan;63(1):74-83. Review.

7. van Echten-Deckert, G., Giannis, A., Schwarz, A., Futerman, A.H. and Sandhoff, K.
   1-Methylthiodihydroceramide, a novel analog of dihydroceramide, stimulates sphinganine degradation resulting in decreased de novo sphingolipid biosynthesis.
   J. Biol. Chem., 1998 Jan 9;273(2):1184-91.

8. Futerman, A.H. and Liscovitch, M.
   Lipids in vesicle trafficking and secretion. In: "Cellular and Molecular Mechanisms of Toxin Action: Secretory Systems and Toxins" (Eds: M. Linial, A. Grasso, P. Lazarovic)
   Harwood Academic Publishers, Harwood Academic Publishers pp. 109-130. 1998.

Back to top

1997

1. Schwarz, A., Terstappen, G.C. and Futerman, A.H.
   Isolation of gangliosides by cloud-point extraction with a nonionic detergent.
   Analyt. Biochem., 1997 Dec 15;254(2):221-5.

2. Schwarz, A., and Futerman, A.H.
   Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth.
   J. Neurosci., 1997 May 1;17(9):2929-38.

3. Schwarz, A. and Futerman, A.H.
   Determination of the localization of gangliosides using anti-ganglioside antibodies: comparison of fixation methods.
   J. Histochem. Cytochem., 1997 Apr;45(4):611-8.

4. Samuel, N., Wonnacott, S., Lindstrom, J. and Futerman, A.H.
   Parallel increases in [alpha-125I]bungarotoxin-binding and alpha 7 nicotinic subunit immunoreactivity during the development of rat hippocampal neurons in culture.
   Neurosci. Letts., 1997 Feb 7;222(3):179-82.

5. Safran, N., Haring, R., Shainberg, A., Zisling, R., Futerman, A.H., Shahar, A.
   Nerve cell death induced by Ca2+ ionophores in dissociated hippocampal cultures. Protective action of the NMDA antagonist MK-801.
   Adv. Exp. Med. Biol., 1997 May 1;17(9):2929-38.

6. Boldin, S. and Futerman, A.H.
   Glucosylceramide synthesis is required for bFGF and laminin to stimulate axonal growth.
   J. Neurochem., 1997 Feb;68(2):882-5.

7. Meivar-Levy, I., Sabanay, H., Bershadsky, A.D. and Futerman, A.H.
   The role of sphingolipids in the maintenance of fibroblast morphology: the inhibition of protrusional activity, cell spreading, and cytokinesis induced by fumonisin B1 can be reversed by ganglioside GM3.
   J. Biol. Chem., 1997 Jan 17;272(3):1558-64.

Back to top

1996

1. Sofer, A. and Futerman, A.H.
   The rate of retrograde transport of cholera toxin from the plasma membrane to the Golgi apparatus and endoplasmic reticulum decreases during neuronal development.
   J. Neurochem., 1996 Nov;67(5):2134-40.

2. Schwarz A, Futerman AH.
   The localization of gangliosides in neurons of the central nervous system: the use of anti-ganglioside antibodies.
   Biochim Biophys Acta., 1996 Oct 29;1286(3):247-67. Review.

3. Sofer A, Schwarzmann G, Futerman AH.
   The internalization of a short acyl chain analogue of ganglioside GM1 in polarized neurons.
   J Cell Sci., 1996 Aug;109 ( Pt 8):2111-9.

4. Hirschberg, K., Zisling, R., van Echten-Deckert, G. and Futerman, A.H.
   Ganglioside synthesis during the development of neuronal polarity: major changes occur during axonogenesis and axon elongation, but not during dendrite growth or during synaptogenesis.
   J. Biol. Chem., 1996 Jun 21;271(25):14876-82.

5. Futerman, A.H.
   Membranes for membranes sake. Book review of "Biomembranes: A General Survey".
   Trends Cell Biol., 5, 283-284. 1996.

6. Futerman, A.H. and Banker, G.A.
   The economics of neurite outgrowth -- the addition of new membrane to growing axons.
   Trends Neurosci., 1996 Apr;19(4):144-9. Review.

7. Harel, R. and Futerman, A.H.
   A newly-synthesized GPI-anchored protein, Tag-1/axonin-1, is inserted into axonal membranes along the entire length of the axon and not exclusively at the growth cone.
   Brain. Res., 1996 Mar 18;712(2):345-8.

Back to top

1995

1. Futerman, A.H.
   Inhibition of sphingolipid synthesis: effects on glycosphingolipid/GPI-anchored protein microdomains.
   Trends Cell Biol ., 1995 Oct;5(10):377-80.

2. Futerman, A.H., Hirschberg, K., Meivar-Levy, I., Rapaport, E., Schwarz, A., Sofer, A., Zisling, R.
   Vesicle transport during cell growth and in the maintenance of cell polarity.
   Biochem. Soc. Trans., 1995 Aug;23(3):530-4. Review.

3. Sofer, A. and Futerman, A.H.
   Cationic amphiphilic drugs inhibit the internalization of cholera toxin to the Golgi apparatus and the subsequent elevation of cyclic AMP.
   J. Biol. Chem., 1995 May 19;270(20):12117-22.

4. Schwarz, A. Rapaport, E.,Hirschberg, K. and Futerman, A.H.
   A regulatory role for sphingolipids in neuronal growth: Inhibition of sphingolipid synthesis and degradation have opposite effects on axonal branching.
   J. Biol. Chem., 1995 May 5;270(18):10990-8.

5. Koval, M., Futerman, A.H. and Pagano, R.E.
    Sphingomyelin synthesis in endosomal compartments?
   Trends Cell Biol., 1995 Apr;5(4):148-9; author reply 149.

Back to top

1994

1. Meivar-Levy, I., Horowitz, M. and Futerman, A.H.
   Analysis of glucocerebrosidase activity using N-(1-[14C]hexanoyl-D-eythro-glucosphingosine demonstrates a correlation between levels of residual enzyme activity and the type of Gaucher disease.
   Biochem. J., 1994 Oct 15;303 ( Pt 2):377-82.

2. Bershadsky, A.D. and Futerman, A.H.
   Disruption of the Golgi apparatus by Brefeldin A blocks cell polarization and inhibits directed cell migration.
   Proc. Natl. Acad. Sci. (U.S.A.), 1994 Jun 7;91(12):5686-9.

3. Futerman, A.H.
   An update on sphingolipid synthesis and transport along the secretory pathway.
   Trends Glycosci. Glycotechnol ., 6, 143-153. 1994.

Back to top

1993

1. Boudker, O. and Futerman, A.H.
   Detection and characterization of ceramide-1-phosphate phosphatase activity in rat liver plasma membrane.
   J. Biol. Chem., 1993 Oct 15;268(29):22150-5.

2. Harel, R. and Futerman, A.H.
   Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons.
   J. Biol. Chem., 1993 Jul 5;268(19):14476-81.

3. Hirschberg, K., Rodger, J. and Futerman, A.H.
   The long chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
   Biochem. J., 1993 Mar 15;290 ( Pt 3):751-7.

4. Futerman, A.H., Khanin, R. and Segel, L.A.
   Lipid diffusion in neurons.
   Nature, 1993 Mar 11;362(6416):119.

Back to top