We study epigenetic events that contribute to cellular differentiation, early development and cancer. To address these fundamental questions, we develop and apply innovative cutting-edge single-molecule technologies.
The activity of genes and regulatory elements is modulated by their cell type-specific chromatin organization. Histone modifications and chromatin regulators play important roles in cellular differentiation and development. Chromatin structure is constantly changing in response to developmental and environmental cues; this dynamic regulation is the basis for cellular plasticity. Epigenetic deregulation is common in a wide spectrum of diseases, from developmental disorders to many types of cancers. We develop methodologies at the interface of genomics and proteomics, with the goal of paving the way towards deeper understanding of chromatin regulation, as well as the development of therapeutic and diagnostic tools.
Single-Molecule Imaging of the Epigenome