Using single-cell methods to analyze the heterogeneity during macrophages infection with Salmonella enterica
- How bacteria regulate different virulence strategies to optimize pathogenicity in the host environment.
- How do innate immune cells recognize pathogens, integrate signals from bacterial PAMPs and determine cell fate.
- Ongoing improvement of the methodologies we apply to study host-pathogen interactions.
- Characterize the in vivo landscape of infection at a resolution of individual host-pathogen encounters: what are the infection 'bottlenecks', what are the cell population that expand in different tissues?
Watch the following presentation from the CSHL meeting, describing my latest work here.
Analyzing the early events of in vivo infection using single cell technologies