The field of host-pathogen interaction is poised at a cross-roads where progress depends upon integrating disparate disciplines. Using mouse immunology, microbiology, single-cell approaches and computational data analyses our lab provides a unique combination in probing the host-pathogen interface.
The work in the lab centers on salmonella infection of mouse macrophages as a tractable in vitro host-pathogen system. We use this model to develop state of the art high throughput genomic tools and interdisciplinary approaches, and then apply them to various in vivo infection models to address critical biological aspects of host-pathogen biology.
See: Avraham et al, Nature Protocols 2016 Avital, Avraham et. al. Genome Biology 2017