The Cancer Epigenome in Single-Molecule and Single-Cell resolution

We established a single-molecule system for mapping combinatorial chromatin modifications, and a single-cell platform to analyze a wide panel of histone modifications and chromatin regulators. We apply these powerful methods to address basic questions in epigenetic regulation of various cancer models.


Single-Cell Epigenetic Analysis of Tumors  


The Effect of Oncohistone Mutations on the Combinatorial Epigenome


Epigenetic and Metabolic Rewiring in IDH-mutant Gliomas


Epigenetic Drivers of B-cell Lymphomas


Epigenetics of Breast Cancer