We established a single-molecule system for mapping combinatorial chromatin modifications, and a single-cell platform to analyze a wide panel of histone modifications and chromatin regulators. We apply these powerful methods to address basic questions in epigenetic regulation of various cancer models.
Single-Cell Epigenetic Analysis of Tumors
The Effect of Oncohistone Mutations on the Combinatorial Epigenome
Epigenetic and Metabolic Rewiring in IDH-mutant Gliomas
Epigenetic Drivers of B-cell Lymphomas