The Department of Immunology and Regenerative Biology (IRB) currently comprises
17 research groups and a total of over 200 people. We are located on the Weizmann
campus in the Candiotty, Britannia and Wolfson buildings.
Research activities of the IRB Department span a broad spectrum of basic and clinically
relevant questions. Topics range from fundamental aspects of cancer, hematopoiesis, cell
differentiation, metabolism, inter-cellular communication, extracellular matrix remodeling and
the genetic and epigenetic changes that contribute to these processes. With a unique focus
on immune cell development and function, we study a wide range of physiological and
pathophysiological settings, including the host-pathogen interface, embryonic development,
inflammation, tissue regeneration post infection and injury, and vascular and lymph
angiogenesis. State-of-the-art approaches developed by our members include intra-vital
and whole organ 3D imaging, multiplexed ex vivo staining, conditional gene manipulation in
animal models, organoid research, advanced genomics and proteomics, and human-derived
samples and their bioinformatic analysis at the single cell level. Combining pre-clinical
mouse models and patient samples, we also develop novel therapeutic strategies for
improved immunotherapies and vaccinations.