Publications

  1. Goldman A., Mullokandov M., Zaltsman Y., Regev L., Levin-Zaidman S. & Gross A. (2024). MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion.  EMBO Reports. 2024 Jan , 25 (1):45-67.
  2. Entin-Meer M., Bigelman E. B., Pasmanik-Chor M. P. C., Dassa B. D., Gross A. G., Itkin M. I., Malitsky S. M., Dorot O. D., Pichinuk E. P., Dezorell N. M. & Keren G. K. (2021). Kynurenic acid- a key metabolite protecting the heart from an ischemic damage.  European Heart Journal. 2021 Oct , 42 (Supplement_1).
  3. Filanovsky K., Haran M., Mirkin V., Braester A., Shevetz O., Stanevsky A., Sigler E., Votinov E., Zalzman-Amir Y., Berrebi A., Gross A. & Shvidel L. (2020). Perpheral blood cell mitochondrial dysfunction in myelodysplastic syndrome can be improved by a combination of coenzyme Q10 and carnitine: Blood cell mitochondrial dysfunction in myelodysplastic syndrome.  Mediterranean Journal of Hematology and Infectious Diseases. 2020 Oct , 12 (1):e2020072-.
  4. Khan D. H., Mullokandov M., Wu Y., Voisin V., Gronda M. V., Hurren R., Wang X., MacLean N., Jeyaraju D. V., Jitkova Y., Xu G. W., Laister R. C., Seneviratne A., Blatman Z., Ketala T., Bader G. D., Marhon S. A., Carvalho D. D. D., Minden M. D., Gross A. & Schimmer A. D. (2020). Mitochondrial carrier homolog 2 is necessary for AML survival.  Blood. 2020 Jul , 136 (1):81-92.
  5. Seneviratne A. K., Xu M., Henao J. J. A., Fajardo V. A., Hao Z., Voisin V., Xu G. W., Hurren R., Kim S., MacLean N., Wang X., Gronda M., Jeyaraju D., Jitkova Y., Ketela T., Mullokandov M., Sharon D., Thomas G., Chouinard-Watkins R., Hawley J. R., Schafer C., Yau H. L., Khuchua Z., Arnan A., Al-awar R., Gross A., Claypoo S. M., Bazinet R., Lupien M., Chan S., De Carvalho D. D., Minden M. D., Bader G. D., Stark K. D., LeBlanc P. & Schimmer A. D. (2019). The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids.  Cell Stem Cell. 2019 Apr , 24 (4):621-636.
  6. Bahat A. & Gross A. (2019). Mitochondrial plasticity in cell fate regulation.  Journal of Biological Chemistry. 2019 Sept , 294 (38):13852-13863.
  7. Bahat A., Goldman A., Zaltsman Y., Khan D. H., Halperin C., Amzallag E., Krupalnik V., Mullokandov M., Silberman A., Erez A., Schimmer A. D., Hanna J. H. & Gross A. (2018). MTCH2-mediated mitochondrial fusion drives exit from naive pluripotency in embryonic stem cells.  Nature Communications. 2018 Dec , 9 .
  8. Galluzzi L., Vitale I., Aaronson S. A., Abrams J. M., Adam D., Agostinis P., Alnemri E. S., Altucci L., Amelio I., Andrews D. W., Annicchiarico-Petruzzelli M., Antonov A. V., Arama E., Baehrecke E. H., Barlev N. A., Bazan N. G., Bernassola F., Bertrand M. J. M., Bianchi K., Blagosklonny M. V., Blomgren K., Borner C., Boya P., Brenner C., Campanella M., Candi E., Carmona-Gutierrez D., Cecconi F., Chan F. K. -., Chandel N. S., Cheng E. H., Chipuk J. E., Cidlowski J. A., Ciechanover A., Cohen G. M., Conrad M., Cubillos-Ruiz J. R., Czabotar P. E., D'Angiolella V., Dawson T. M., Dawson V. L., De laurenzi V., De Maria R., Debatin K., DeBerardinis R. J., Deshmukh M., Gross A., Kimchi A., Oren M. & Wallach D. (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.  Cell Death and Differentiation. 2018 Mar , 25 (3):486-541.
  9. Aloni E., Ruggiero A., Gross A. & Segal M. (2018). Learning Deficits in Adult Mitochondria Carrier Homolog 2 Forebrain Knockout Mouse.  Neuroscience. 2018 Dec , 394 :156-163.
  10. Jenkins A., Lengyel I., Rutter G. A., Lowe N., Shai I., Tirosh A., Petro T., Khamaisi M., Andrews S., Zmora N., Gross A., Maret W., Lewis E. C. & Moran A. (2018). Obesity, diabetes and zinc: A workshop promoting knowledge and collaboration between the UK and Israel, november 28-30, 2016-Israel.  Journal of Trace Elements in Medicine and Biology. 2018, 49 :79-85.
  11. Gross A. & Katz S. G. (2017). Non-apoptotic functions of BCL-2 family proteins.  Cell Death and Differentiation. 2017 Aug , 24 (8):1348-1358.
  12. Ruggiero A., Aloni E., Korkotian E., Zaltsman Y., Oni-Biton E., Kuperman Y., Tsoory M., Shachnai L., Levin-Zaidman S., Brenner O., Segal M. & Gross A. (2017). Loss of forebrain MTCH2 decreases mitochondria motility and calcium handling and impairs hippocampal-dependent cognitive functions.  Scientific Reports. 2017 Mar , 7 .
  13. Item F., Wueest S., Lemos V., Stein S., Lucchini F. C., Denzler R., Fisser M. C., Challa T. D., Pirinen E., Kim Y., Hemmi S., Gulbins E., Gross A., O'Reilly L. A., Stoffel M., Auwerx J. & Konrad D. (2017). Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function.  Nature Communications. 2017 Dec , 8 (1).
  14. Gross A., Tasdogan A. & Fehling H. J. (2017). The IFN-1 > BID > ROS pathway: Linking DNA damage with HSPC malfunction.  Cell Cycle. 2017 May , 16 (9):819-820.
  15. Rottiers V., Francisco A., Platov M., Zaltsman Y., Ruggiero A., Lee S. S., Gross A. & Libert S. (2017). MTCH2 is a Conserved Regulator of Lipid Homeostasis.  Obesity. 2017 Mar , 25 (3):616-625.
  16. Buzaglo-Azriel L., Kuperman Y., Tsoory M., Zaltsman Y., Shachnai L., Levin-Zaidman S., Bassat E., Michailovici I., Sarver A., Tzahor E., Haran M., Vernochet C. & Gross A. (2016). Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity.  Cell Reports. 2016 Feb , 14 (7):1602-1610.
  17. Gross A. (2016). BCL-2 family proteins as regulators of mitochondria metabolism.  Biochimica et Biophysica Acta - Bioenergetics. 2016 Aug , 1857 (8):1243-1246.
  18. Gross A., Zaltsman Y. & Maryanovich M. (2016). The ATM-BID pathway plays a critical role in the DNA damage response by regulating mitochondria metabolism.  Cell Death and Differentiation. 2016 Jan , 23 (1):182.
  19. Maryanovich M., Zaltsman Y., Ruggiero A., Goldman A., Shachnai L., Porat Z., Golan K. & Gross A. (2015). An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate.  Nature Communications. 2015 Jul , 6 .
  20. Orlik J., Schüngel S., Buitrago-Molina L. E., Marhenke S., Geffers R., Endig J., Lobschat K., Rössler S., Goeppert B., Manns M. P., Gross A. & Vogel A. (2015). The BH3-only protein BID impairs the p38-mediated stress response and promotes hepatocarcinogenesis during chronic liver injury in mice.  Hepatology. 2015 Sept , 62 (3):816-828.
  21. Weaver D., Eisner V., Liu X., Várnai P., Hunyady L., Gross A. & Hajnóczky G. (2014). Distribution and Apoptotic Function of Outer Membrane Proteins Depend on Mitochondrial Fusion.  Molecular Cell. 2014 Jun , 54 (5):870-878.
  22. Haran M. & Gross A. (2014). Balancing glycolysis and mitochondrial OXPHOS: Lessons from the hematopoietic system and exercising muscles.  Mitochondrion. 2014 Nov , 19 (Part A):3-7.
  23. Shamas-Din A., Bindner S., Zhu W., Zaltsman Y., Campbell C., Gross A., Leber B., Andrews D. W. & Fradin C. (2013). TBid undergoes multiple conformational changes at the membrane required for bax activation.  Journal of Biological Chemistry. 2013 Jul , 288 (30):22111-22127.
  24. Maryanovich M. & Gross A. (2013). A ROS rheostat for cell fate regulation.  Trends in Cell Biology. 2013 Mar , 23 (3):129-134.
  25. Zinkel S. S., Yin X. M. & Gross A. (2013). Rejuvenating bi(d)ology.  Oncogene. 2013 Jul , 32 (27):3213-3219.
  26. Katz C., Zaltsman-Amir Y., Mostizky Y., Kollet N., Gross A. & Friedler A. (2012). Molecular basis of the interaction between proapoptotic truncated BID (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) protein: Key players in mitochondrial death pathway.  Journal of Biological Chemistry. 2012 Apr , 287 (18):15016-15023.
  27. Maryanovich M., Oberkovitz G., Niv H., Vorobiyov L., Zaltsman Y., Brenner O., Jung S. & Gross A. (2012). The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells.  Nature Cell Biology. 2012 May , 14 (5):535-541.
  28. Robinson A. J., Kunji E. R. & Gross A. (2012). Mitochondrial carrier homolog 2 (MTCH2): The recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis.  Experimental Cell Research. 2012 Jul , 318 (11):1316-1323.
  29. Cabon L., Galán-Malo P., Bouharrour A., Delavallée L., Brunelle-Navas M. N., Lorenzo H. K., Gross A. & Susin S. A. (2012). BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.  Cell Death and Differentiation. 2012 Feb , 19 (2):245-256.
  30. Gross A. (2011). A yeast BH3-only protein for the rescue.  Cell Death and Differentiation. 2011 Oct , 18 (10):1543-1544.
  31. Yivgi-Ohana N., Eifer M., Addadi Y., Neeman M. & Gross A. (2011). Utilizing mitochondrial events as biomarkers for imaging apoptosis.  Cell Death & Disease. 2011 Jun , 2 (6).
  32. Zaltsman Y., Shachnai L., Yivgi Ohana O. N., Schwarz M., Maryanovich M., Houtkooper R. H., Vaz F. M., De Leonardis L. F., Fiermonte G., Palmieri F., Gillissen B., Daniel P. T., Jimenez E., Walsh S., Koehler C. M., Roy S. S., Walter L., Hajnoczky G. & Gross A. (2010). MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria.  Nature Cell Biology. 2010 Jun , 12 (6):553-562.
  33. Gross A. (2010). Aven-uing between nuclear export and cell cycle arrest.  Cell Cycle. 2010 Oct , 9 (20):4043-4051.
  34. Gross A. (2010). M(a)TCH-ing up mitochondrial apoptosis.  Cell Cycle. 2010 Aug , 9 (15):2925-2926.
  35. Schuengel S., Buitrago-Molina L. E., Nalapareddy P. D., Lebofsky M., Manns M. P., Jaeschke H., Gross A. & Vogel A. (2009). The Strength of the Fas Ligand Signal Determines Whether Hepatocytes Act as Type 1 or Type 2 Cells in Murine Livers.  Hepatology. 2009 Nov , 50 (5):1558-1566.
  36. Ziporen L., Donin N., Shmushkovich T., Gross A. & Fishelson Z. (2009). Programmed necrotic cell death induced by complement involves a bid-dependent pathway.  Journal of Immunology. 2009 Jan , 182 (1):515-521.
  37. Gross A. (2008). A new Aven-ue to DNA-damage checkpoints.  Trends in Biochemical Sciences. 2008 Nov , 33 (11):514-516.
  38. Schwarz M., Andrade-Navarro M. A. & Gross A. (2007). Mitochondrial carriers and pores: Key regulators of the mitochondrial apoptotic program?.  Apoptosis. 2007 May , 12 (5):869-876.
  39. Zinkel S. S., Hurov K. E. & Gross A. (2007). Bid Plays a Role in the DNA Damage Response.  Cell. 2007 Jul , 130 (1):9-10.
  40. König H. G., Rehm M., Gudorf D., Krajewski S., Gross A., Ward M. W. & Prehn J. H. (2007). Full Length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons.  BMC Cell Biology. 2007 Feb , 8 .
  41. Oberkovitz G., Regev L. & Gross A. (2007). Nucleocytoplasmic shuttling of BID is involved in regulating its activities in the DNA-damage response.  Cell Death and Differentiation. 2007 Sept , 14 (9):1628-1634.
  42. Yacobi K., Tsafriri A. & Gross A. (2007). Luteinizing hormone-induced caspase activation in rat preovulatory follicles is coupled to mitochondrial steroidogenesis.  Endocrinology. 2007 Apr , 148 (4):1717-1726.
  43. Zinkel S., Gross A. & Yang E. (2006). BCL2 family in DNA damage and cell cycle control.  Cell Death and Differentiation. 2006 Aug , 13 (8):1351-1359.
  44. Gross A. (2006). BID as a double agent in cell life and death.  Cell Cycle. 2006 Mar , 5 (6):582-584.
  45. Grinberg M., Schwarz M., Zaltsman Y., Eini T., Niv H., Pietrokovski S. & Gross A. (2005). Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha.  Molecular and Cellular Biology. 2005 Jun , 25 (11):4579-4590.
  46. Zinkel S., Hurov K., Ong C., Abtahl F., Gross A. & Korsmeyer S. (2005). A role for proapoptotic BID in the DNA-damage response.  Cell. 2005 Aug , 122 (4):579-591.
  47. Kamer I., Sarig R., Zaltsman Y., Niv H., Oberkovitz G., Regev L., Haimovich G., Lerenthal Y., Marcellus R. C. & Gross A. (2005). Proapoptotic BID is an ATM effector in the DNA-damage response.  Cell. 2005 Aug , 122 (4):593-603.
  48. Gross A. (2005). Mitochondrial carrier homolog 2: A clue to cracking the BCL-2 family riddle?.  Journal of Bioenergetics and Biomembranes. 2005 Jun , 37 (3):113-119.
  49. Yacobi K., Wojtowicz A., Tsafriri A. & Gross A. (2004). Gonadotropins enhance caspase-3 and -7 activity and apoptosis in the theca-interstitial cells of rat preovulatory follicles in culture.  Endocrinology. 2004 Apr , 145 (4):1943-1951.
  50. Sarig R., Zaltsman Y., Marcellus R. C., Flavell R., Mak T. W. & Gross A. (2003). BID-D59A is a potent inducer of apoptosis in primary embryonic fibroblasts.  Journal of Biological Chemistry. 2003 Mar , 278 (12):10707-10715.
  51. Grinberg M., Sarig R., Zaltsman-Amir Y., Frumkin D., Grammatikakis N., Reuveny E. & Gross A. (2002). tBID homooligomerizes in the mitochondrial membrane to induce apoptosis.  Journal of Biological Chemistry. 2002 Apr , 277 (14):12237-12245.
  52. Gross A. (2001). BCL-2 proteins: Regulators of the mitochondrial apoptotic program.  IUBMB Life. 2001 Sept , 52 (3-5):231-236.

All drawings courtesy of: Odra Noel

Contact: Atan Gross | Tel: +972-8-934-3656 | Fax: +972-8-934-4116