Publications

Selected Peer-reviewed Publications
  1. Pierre P*., Shachar I.*, Matza D., Gatti E., Flavell R.A. and Mellman I. (2000) “Invariant Chain Controls H2-M Proteolysis in Mouse Splenocytes and Dendritic Cells”. J. Exp. Med. 191:1057-1062. *Pierre and Shachar contributed equally to this work.
  2. Flaishon L., Hershkovitz R., Lantner F., Lider O., Alon R., Levo Y., Flavell R.A. and Shachar I. (2000) ”Autocrine Secretion of Interferon γ Negatively Regulates Homing of Immature B Cells”. J. Exp. Med. 192:1381-1387.
  3. Matza D., Wolstein O., Dikstein R. and Shachar I. (2001) “Invariant Chain Induces B Cell Maturation by Activating TAFII105-NF-κB Dependent Transcription Program”. J. Biol. Chem. 276:27203-27206.
  4. Flaishon L., Lantner F., Hershkovitz R., Levo Y. and Shachar I. (2001) “Low Levels of IFN-γ Down-regulate the Integrin-Dependent Adhesion of B cells by Inhibition of Cytoskeleton Rearrangement”. J. Biol. Chem. 276:46701-46706.
  5. Topilski I., Harmelin A., Flavell R.A., Levo Y. and Shachar I. (2002) “Preferential Th1 Immune Response in Invariant Chain- Deficient Mice“. J. Immunol. 168:1610-1617.
  6. Matza D., Lantner F., Bogoch Y., Flaishon L., Hershkovitz R. and Shachar I. (2002) “Invariant Chain Induces B cell Maturation in a Process Which is Independent of its Chaperonic Activity”. Proc. Natl. Acad. Sci U.S.A. 99:3018-3023.
  7. Silkov A., Wolstein O., Shachar I. and Dikstein R. (2002) “Enhanced Apoptosis of B and T Lymphocytes in TAFII105 Dominant Negative Transgenic Mice is Linked to NF-κB”. J. Biol. Chem. 277:17821-17829.
  8. Flaishon L., Topilski I., Shoseyov D., Hershkoviz R., Fireman E., Levo Y., Marmor S., and Shachar I. (2002) “Anti-Inflammatory Properties of Low Levels of IFN-γ”. J. Immunol. Cutting edge: 168:3707-3711.
  9. Becker-Herman S., Lantner F. and Shachar I. (2002) “Id2 Negatively Regulates B cell Differentiation in the Spleen”. J. Immunol. 168:5507-5513.
  10. Schori H., Lantner F., Shachar I.*, and Schwartz M.* (2002) “Severe Immunodeficiency has Opposite Effects on Neural Survival in Glutamate-Susceptible and Resistant Mice: Adverse Effect of B Cells”. J. Immunol. 169:2861-2865. *Equal contribution.
  11. Matza D., Kerem A., Medvedovsky H., Lantner F. and Shachar I. (2002) “Invariant chain induced B cell differentiation requires intramembrane - proteolytic release of the cytosolic domain”. Immunity 17:549-560.
  12. Hart G., Flaishon L., Becker-Herman S. and Shachar I. (2003) “The Ly49D receptor expressed on immature B cells regulates their IFN-γ secretion, actin polymerization and homing”. J. Immunol. 171:4630-4638.
  13. Topilski I., Flaishon L., Naveh Y., Harmelin A., Levo Y. and Shachar I. (2004) “The anti-inflammatory effects of 1,25-Dihydroxyvitamin D3 on Th2 cells in vivo are due in part to the control of integrin-mediated T lymphocyte homing”. Eur. J. Immunol. 34:1068-1076.
  14. Flaishon L., Becker-Herman S., Hart G., Levo Y. Kuziel W.A. and Shachar I. (2004) “Expression of the Chemokine Receptor CCR2 on Immature B cells Negatively Regulates their Cytoskeleton Rearrangement and Migration”. Blood 104:933-941.
  15. Haran M., Chebatco S., Flaishon L., Lantner F., Harpaz N., Valinsky L. Berrebi A. and Shachar I. (2004) “Grb7 expression and cellular migration in chronic lymphocytic leukemia: a comparative study of early and advanced stage disease”. Leukemia 18:1948-1950.
  16. Hart G., Flaishon L., Becker-Herman S. and Shachar I. (2005) “Tight regulation of IFN-γ transcription and secretion in immature and mature B cells by the inhibitory MHC class I receptor, Ly49G2”. J. Immunol. 175:5034-5042.
  17. Becker-Herman S., Arie G., Medvedovsky H., Kerem A. and Shachar I. (2005) “CD74 is a member of the regulated intramembrane proteolysis (RIP) processed protein family”. Mol. Biol. Cell 16:5061-5069.
  18. Starlets D., Gore Y., Binsky I., Haran M., Harpaz N., Shvidel L., Becker-Herman S., Berrebi A. and Shachar I. (2006) “Cell Surface CD74 initiates a signaling cascade leading to cell proliferation and survival”. Blood 107:4807-4816.
  19. Wald O., Weiss I.D., Wald H., Shoham H., Bar-Shavit Y., Beyder K., Galun E., Weiss L., Flaishon L., Shachar I., Nagler A., Lu B., Gerard C., Gao J.-L., Mishani E., Farber J., and Peled A. (2006) “IFN-γ Acts on T Cells to Induce NK Cell Mobilization and Accumulation in Target Organs”. J. Immunol. 176:4716-4729.
  20. Schori H., Shechter R., Shachar I. and Schwartz M. (2007) “Genetic manipulation of CD74 in mouse strains of different backgrounds can result in opposite responses to CNS injury”. J. Immunol. 178:163-171.
  21. Hart G., Flaishon L. and Shachar I. (2007) “IL-12 and IL-18 downregulate B cell migration in an Ly49D-dependent manner”. Eur. J. Immunol. 37:1996-2007.v
  22. Binsky I., Haran M., Starlets D., Gore Y., Lantner F., Harpaz N., Leng L., Goldenberg D.M., Shvidel L., Berrebi A., Bucala R., and Shachar I. (2007) “IL-8 secreted in a MIF and CD74 dependent manner regulates B-CLL survival”. Proc. Natl. Acad. Sci U.S.A. 104:13408-13413.
  23. Lantner F., Starlets D., Gore Y., Flaishon L., Yamit-Hezi A., Dikstein R., Leng L., Bucala R., Machluf Y., Oren M. and Shachar I. (2007) “CD74 induces TAp63 expression leading to B cell survival”. Blood 110:4303-4311.
  24. Hart G., Avin-Wittenberg T. and Shachar I. (2007) “IL-15 regulates immature B cell homing in an Ly49D, IL-12, and IL-18 dependent manner”. Blood, 111:50-59.
  25. Gore Y., Starlets S., Maharshak N., Becker-Herman S., Kaneyuki U., Leng L., Bucala R. and Shachar I. (2008) “Macrophage Migration Inhibitory Factor (MIF) Induces B Cell Survival by Activation of a CD74/CD44 Receptor Complex”. J. Biol. Chem., 283(5):2784-2792.
  26. Sapoznikov A., Pewzner-Jung Y., Kalchenko V., Krauthgamer R., Shachar I.* and Jung S.* (2008) "The Bone Marrow Immune Niche: Perivascular Dendritic cell clusters provide critical B cell survival signals." Nat. Immunol. 9:388-395.
    *Equal contribution
  27. Flaishon L., Hart G., Zelman E., Moussion C., Grabovsky V., Lapidot Tal G., Feigelson S., Margalit R., Harmelin A., Avin- Wittenberg T., Shoseyov D., Alon R., Girard J.-P. and Shachar I. (2008) "Anti-inflammatory effects of an inflammatory chemokine: CCL2 inhibits lymphocyte homing by modulation of CCL21 triggered integrin-mediated adhesions." Blood 112:5016-5025.
  28. Hartmann TN., Grabovsky V., Wang W., Desch P., Rubenzer G., Wollner S., Binsky I., Vallon-Eberhard A., Sapoznikov A., Burger M., Shachar I., Haran M., Honczarenko M., Greil R. and Alon R. (2009) "Circulating B-Cell Chronic Lymphocytic Leukemia Cells Display Impaired Migration to Lymph Nodes and Bone Marrow." Cancer Res. 69:3121-3130.
  29. Berrih-Aknin S., Ruhlmann N., Bismuth J., Cizeron-Clairac G., Zelman E., Shachar I., Dartevelle P., de Rosbo NK., Le Panse R. (2009) "CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia." Ann. Neurol. 66:521-31.
  30. Maharshak N., Hart G., Ron E., Zelman E., Sagiv A., Arber N., Brazowski E., Margalit R., Elinav E., Shachar I. (2010) "CCL2 (pM levels) as a therapeutic agent in inflammatory bowel disease models in mice." Inflammatory Bowl Diseases 16:1496-1504.
  31. Maharshak N., Cohen S., Lantner F., Hart G., Leng L., Bucala R. and Shachar I. (2010) "CD74 is a survival receptor on colon epithelial cells." World Journal of Gastroenterology 16:3258-3266.
  32. Binsky I., Lantner F., Grabovsky V., Harpaz N., Shvidel L., Berrebi A., Goldenberg D.M., Leng L., Bucala R., Alon R., Haran M. and Shachar I. (2010) "TAp63 regulates VLA-4 expression and CLL cell migration to the BM in a CD74 dependent manner." J. Immunol. 184:4761-4769.
  33. Gore Y., Lantner F., Hart G. and Shachar I. (2010) "Mad3 negatively regulates B cell differentiation in the spleen by inducing Id2 expression." Mol. Biol. Cell 21 1864-1871.
  34. Gordin M., Tesio M., Cohen S., Gore Y., Lantner F., Leng L., Bucala R. and Shachar I. (2010) "c-Met and its ligand HGF regulate mature B cell survival in a pathway induced by CD74." J. Immunol. 185 2020-2031.
  35. Manevich-Mendelson E., Grabovsky V., Feigelson S.W., Cinamon G., Gore Y., Goverse G., Monkley SJ, Margalit R, Melamed D., Mebius R.E., Critchley D.R., Shachar I., Alon R. (2010) "Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B cell maturation in the spleen." Blood 116:5907-5918.
  36. Lapter S., Ben-David H., Sharabi A., Zinger H., Telerman A., Gordin M., Leng L., Bucala R., Shachar I., Mozes E. (2011) "A role for the B-cell CD74/macrophage migration inhibitory factor pathway in the immunomodulation of systemic lupus erythematosus by a therapeutic tolerogenic peptide." Immunology 132:87-95.
  37. Cohen S., Shoshana O., Zelman-Toister, E., Maharshak N., Binsky- Ehrenreich I., Gordin M., Hazan-Halevy I, Herishanu Y., Shvidel L., Haran M., Leng L., Bucala R., Harroch S., Shachar I. (2012) "The Cytokine Midkine and its Receptor RPTPς Regulate B Cell Survival in a Pathway Induced by CD74." J. Immunol. 188:259-269.

Invited Reviews

  1. Matza D., Kerem A. and Shachar I. (2003) “Invariant chain, a chain of command”. Trends in Immunol. 24:246-248.
  2. Shachar I. and Haran M. (2011) "The secret second life of an innocent chaperone: The story of CD74 and B-cell/chronic lymphocytic leukemia (CLL) cell survival." Leukemia and Lymphoma 52:1446-14454.

Book Chapters

  1. MIF book: Chapter "CD74, the natural receptor for MIF, regulates cell survival in health and disease." In press.