| R | esearch activities in the department cover a broad spectrum of burning basic and clinical questions ranging from fundamental aspects of hematopoiesis and differentiation to the physiological principles underlying mucosal inflammation, cancer immunology, immune tolerance, innate immunity- host/microbe interactions and cell migration. Focusing on the mouse as model organism, department members investigate molecular mechanisms underlying immune disorders, such as immunodeficiencies, innate immunopathologies and autoimmunity. Therapeutic strategies to be translated into the clinic include novel immunotherapies, as well as the development of improved stem cell transplantation and vaccination protocols. To uncover physiological and pathological roles of the immune system department members use state of the art approaches ranging from intravital imaging, genomics and systems immunology to elucidate how cytokines, chemokines, gene regulation and immune signalling cascades orchestrate the complex communication and function of the immune system in health and disease. |
