In this course studens will read grounbreaking publications that have changed paradigms and concepts regarding the hematopoetic system and different types of leukemia.
Students will present an introduction to the topic and critically analyze the manuscripts.
The course introduction presentation can be dowloaded here Presentation
Articles
Stem cell Differentiation
1) Prospective identification of hematopoietic lineage choice by deep learning
2) Platelet-biased stem cells reside at the apex of the hematopoietic stem-cell hierarchy
3) The Branching Point in Erythro-Myeloid differentiation
4) Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors
5) Distinct routes of lineage development reshape the human blood hierarchy across ontogeny
Stem cell kinetics and dynamics
1) Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions
2) Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling
3) Exit from dormancy provokes DNA-damage- induced attrition in hematopoietic stem cells
4) Fundamental properties of unperturbed hematopoiesis from stem cells in vivo
5) Clonal dynamics of native hematopoiesis
HSCs and Aging
1) Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate
2) Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
3) Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
4) Detectable clonal mosaicism from birth to old age and its relationship to cancer
5) The unfolded protein response governs integrity of the hematopoietic stem-cell pool during stress
Leukomognesis
1) CpG Island Hypermethylation mediated by DNMT3A Is a Consequence of AML Progression
2) Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
Stem cell and leukemia evolution
1) Hematopoietic differentiation is required for Initiation of acute myeloid leukemia
3) Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
4) Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia
5) Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia
HSCs and leukemia metabolism
2) Metabolic gatekeeper function of B-lymphoid transcription factors
3) Hematopoietic stem cells require a highly regulated protein synthesis rate
Microenviroment stem cells and leukemia
1) Distinct bone marrow blood vessels differentially regulate haematopoiesis
2) Age-dependent modulation of vascular niches for haematopoietic stem cells
4) Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment