Department of Molecular Cell Biology

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Dr. Leeat Keren
Systems tissue pathology

Prof. Shalev Itzkovitz
Systems Biology of Mammalian Tissues

Prof. Sima Lev
Cell Signaling in Cancer Development and Metastasis

Prof. Eran Segal
Developing Computational Models for Personalized Medicine

Prof. Oren Schuldiner
Mechanisms of neuronal remodeling

Prof. Valery Krizhanovsky
Cellular senescence in tissue damage cancer and aging

Prof. Yardena Samuels
Melanoma Functional Genomics

Prof. Ravid Straussman
The study of resistance to anti-cancer therapy

Dr. Yonatan Stelzer
Epigenetics in development and disease

Prof. Gil Levkowitz
Linking genes, development and function of the zebrafish hypothalamus

Prof. Uri Alon
Systems biology and physics of behavior

Prof. Varda Rotter
The role of p53 in maintaining genomic plasticity

Prof. Eldad Tzahor
Cardiomyocyte cell-cycle control and dedifferentiation

Prof. Moshe Oren
Molecular and cellular biology of cancer

Prof. Elior Peles
Development of myelinated nerves

Prof. Yehiel Zick
Cross talk between insulin resistance, animal lectins and bone remodeling

Dr. Itay Tirosh
Tumor Systems Biology

Research in our department centers around molecular mechanisms that control different aspects of cell biology during development and disease states. Large part of the research focuses on cancer heterogeneity at both genomics, proteomics, and the cancer microbiome. We bring unique and innovative research approaches that shed light on organ function in vivo, such as heart, liver, pancreas, gut, and the nervous system. Studies at the department explore diverse cell biology topics including cell-cell communication, cytoskeletal organization; intracellular signaling; senescence, differentiation; physiology and metabolism.

Latest PUBLICATIONS

Prediction of type 2 diabetes mellitus onset using logistic regression-based scorecards

Edlitz Y. & Segal E. (2022), eLife. 11

Physically interacting beta-delta pairs in the regenerating pancreas revealed by single-cell sequencing

Yanowski E., Yacovzada N. S., David E., Giladi A., Jaitin D., Farack L., Egozi A., Ben-Zvi D., Itzkovitz S., Amit I. & Hornstein E. (2022), Molecular metabolism (Germany). 60, p. 101467-101467

Recording bacterial responses to changes in the gut environment

Zahavi L. & Segal E. (2022), Science (American Association for the Advancement of Science). 376, 6594, p. 697-698

An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes

Jaiswal A., Verma A., Dannenfelser R., Melssen M., Tirosh I., Izar B., Kim T., Nirschl C. J., Devi K. S. P., Olson W. C., Slingluff C. L., Engelhard V. H., Garraway L., Regev A., Minkis K., Yoon C. H., Troyanskaya O., Elemento O., Suárez-Fariñas M. & Anandasabapathy N. (2022), Cancer Cell. 40, 5, p. 524-544.e5

From genes to modules, from cells to ecosystems

Keidar Haran T. & Keren L. (2022), Molecular Systems Biology. 18, 5, e10726

Events

MCB MCB RETREAT 2022 Kfar Blum 4-6 September 2022

Date: Sunday, September 4th, 2022

Hour: 8:00

Location: https://tinyurl.com/MCB2022Retreat

See all events

news

Date: June 26, 2022

Congratulations to Prof. Yardena Samuels

Elected as the President of the European Association for Cancer Research
Read more about Congratulations to Prof. Yardena Samuels
Date: April 24, 2022

Congratulations to Prof. Varda Rotter

Elected as a Fellow of the American Association for Cancer Research Academy (AACR)
Read more about Congratulations to Prof. Varda Rotter
Date: February 2, 2022

Congratulations to Prof. Shalev Itzkovitz

Recipient of the Rappaport Prize for a Young Scientist