Publications | Department of Molecular Cell Biology

2025

A Drosophila screen of schizophrenia genes highlights neural and glial MMPs in neuronal remodeling

Keret S., Meltzer H., Marmor-Kollet N. & Schuldiner O. (2025), Life Science Alliance. 8, 12, e202503504

Integrated spatial proteomic analysis of breast cancer heterogeneity unravels cancer cell phenotypic plasticity

Mardamshina M., Karagach S., Mohan V., Arad G., Necula D., Golani O., Fellus-Alyagor L., Shenoy A., Krol K., Pirak D., Itzhacky N., Marin I., Shalmon B., Addadi Y., Sharan R., Gal-Yam E., Barshack I. & Geiger T. (2025), Nature Communications. 16, 10482

Molecular Systems Biology at 20: reflecting on the past, envisioning the future

Bheda P., Hou J., Aebersold R., Alon U., Bader J. S., Bardwell L., Liu E. T., Locke J. C., Mann M., Millar A. J., Naef F., Pilpel Y., Shamir R. & Vitkup D. (2025), Molecular Systems Biology

Sirt6 prevents the age-related decline of H2S through the control of one-carbon metabolism

Touitou N., Nahum L., Feldman-Trabelsi S., Avivi M. Y., Aon M. A., Naiman S., Rathaus M., Gertler A. A., Roichman A., Dvir L. B., Bernier M., Banskota N., Beck L., Nagar R., Schwartz Z., Price N. L., Harel M., Lerrer B., Ishii I., Senderowitz H., Moaddel R., Geiger T., de Cabo R. & Cohen H. Y. (2025), Proceedings of the National Academy of Sciences of the United States of America. 122, 46, e251408412

Characterization of the tumor microbiome of brain metastases and glioblastoma reveals tumor-type-specific and location-specific microbial signatures

Gigi E., Gavert N., Raijman-Nagar L., Zwang Y., Zemach H., Livyatan I., Levy-Barda A., Laviv Y., Kanner A. A., Amiel A., Siegal T., Leibovici A., Selezen I., Badran O., Zohar Y., Safadi E., Prather L. L., Helfer C. R., Castro P., Barshack I., Dadosh T., Levin-Zaidman S., Goliand I., Golani O., Horn S., Mandel J. J., Shental N., Shai A., Yust-Katz S. & Straussman R. (2025), Nature Cancer. 6, 11, p. 1761-1776

Principles of bacteriostatic and bactericidal antibiotics at subinhibitory concentrations

Vaisbourd E., Glass D. S., Yang Y., Mayo A., Bren A. & Alon U. (2025), mBio. 16, 11, e0206625

Open problems in ageing science: a roadmap for biogerontology

Talay A., Belikov A. V., To P. K. P., Alfatemi H. H., Alon U., Deelen J., Ewald C. Y., Gems D., Gorbunova V., Gruber J., Hagg S., Hemming J., Horvath S., Kaya A., Lewis C. J., Maier A. B., Marinova M. B., Pawelec G., Peleg S., Rattan S., Scheibye-Knudsen M., Schmauck-Medina T., Saroyan V., Seluanov A., Stolzing A., Teeling E., Williams R. W., White T., Unfried M. & De Magalhaes J. P. (2025), GeroScience

A spatial atlas of human gastrointestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology

Azulay N., Milo I., Bussi Y., Ben-Uri R., Haran T. K., Eldar M., Elhanani O., Harnik Y., Yakubovsky O., Nachmany I., Salame T., Wartenberg M., Bertheau P., Michonneau D., Socie G. & Keren L. (2025), Science Translational Medicine. 17, 823, eadu6032

p53 regulates the expression of histone modifiers to restrict stemness and maintain differentiated luminal identity in breast cancer

Aylon Y., Furth N., Pirona A. C., Lavie A., Fedorova O., Hassin O., Padrão N., Steinmetz M., Sarusi-Potuguez A., Fellus-Alyagor L., Shimoni I., Dassa B., Zwart W., Shema E. & Oren M. (2025), Proceedings of the National Academy of Sciences - PNAS. 122, 44, e252264612

Evolutionarily conserved role of oxytocin in zebrafish social reward encoding

Kareklas K., Herrera-Castillo L., Levkowitz G. & Oliveira R. F. (2025), Biology Letters. 21, 11, 20250628

Vagal blockade of the brain-liver axis deters cancer-associated cachexia

Garrett A., Darzi N., Deshmukh A., Rosenfeld N., Goldman O., Adler L., Bab-Dinitz E., Singer O., Hassani Najafabadi A., Wong C. W., Bose S., Randon P. M., Bustamante F., Larios R., Brandis A., Mehlman T., Smaglo B., Chang P., Oliva J., Haymaker C., Nagawekar L., Wu S. R., Huang Y., Shen A., Vora A., Padilla J. F., Pfeffer A., Sutherland G., Starr M., Zimmers T., Zhu Y., Morizio J., Erez A. & Shen X. (2025), Cell. 188, 21, p. 6044-6063.e24

Towards a reference cell atlas of liver diversity over the human lifespan

Taylor S. A., Bader G. D., Macparland S., Mullen A. C., Andrews T., Cuenca A. G., Dasgupta R., Gehring A. J., Grun D., Guilliams M., Gulamhusein A., Henderson N. C., Hirschfield G., Huppert S. S., Itzkovitz S., Jiang Z. G., Lauer G. M., Mcgilvray I., Mysore K. R., Pirola C. J., Quon G., Rahbari M., Regev A., Ricciuto A., Scott C. L., Sharma A., Sookoian S., Tana M. M., Teichmann S. A., Vallier L., Vlachos I. S., Wang B. & Zhen M. (2025), Nature Reviews Gastroenterology and Hepatology

IceQream: Quantitative chromosome accessibility analysis using physical TF models

Bercovich A., Lifshitz A., Eldar M., Cheng S., Stok Ranen R., Stelzer Y. & Tanay A. (2025), Nature Communications. 16, 8984

IceQream: Quantitative chromosome accessibility analysis using physical TF models

Bercovich A., Lifshitz A., Eldar M., Cheng S., Stok Ranen R., Stelzer Y. & Tanay A. (2025), Nature Communications. 16, 8984

CD4 T cells acquire Eomesodermin to modulate cellular senescence and aging

Elyahu Y., Feygin I., Eremenko E., Pinkas N., Zemer A., Shicht A., Berner O., Avigdory-Meiri R., Nemirovsky A., Reshef K., Roitman L., Krizhanovsky V. & Monsonego A. (2025), Nature Aging. 5, 10, p. 1970-1982

Transcriptomic profiling of shed cells enables spatial mapping of cellular turnover in human organs

Barkai T., Yakubovsky O., Korem Kohanim Y., Bahar Halpern K., Shir S., Oren N., Fine M., Kelmer P., Talmon A., Israeli A., Pencovich N., Pery R., Nachmany I. & Itzkovitz S. (2025), Molecular Systems Biology

Artificial intelligence in metabolic research

Holst J. J., Scheele C., Scherer P. E., Jia W., Segal E., Slavov N., Loos R. J. F., Vahedi G., Sun L., Babu M. M., McCradden M. D. & Jacobs P. G. (2025), Nature Metabolism. 7, 11, p. 2183-2186

Stool shed cell transcriptomics mirrors tumor biology and enables colorectal cancer diagnosis

Bahar Halpern K., Kent I., Yakubovsky O., Ben-Moshe S., Barkai T., Fine M., Novoselsky R., Israeli A., Nachmany I. & Itzkovitz S. (2025), Scientific Reports. 15, 34413

Challenges and Opportunities in Spatiotemporal Models of Mammalian Gastrulation

Rubinstein H., Mayshar Y. & Stelzer Y. (2025), Annual Review of Cell and Developmental Biology. 41, 1, p. 135-158

PNKP targeting engages the autophagic machinery through STING and STAT3 to potentiate ferroptosis and chemotherapy in TNBC

Maimon A., Puzzovio P. G., Vinik Y., Hannuna G. D., Donzelli S., Rutigliano D., Blandino G. & Lev S. (2025), Redox Biology. 86, 103775

Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements

Levy G., Rokach M., Fischer I., Kimchi-Feldhorn O., Shoob S., Bar E., Rosenberg T., Bartman J., Parnas H., Grad M., Israel-Elgali I., Sfadia G. E., Trangle S. S., Vainshtein A., Eisenbach Y. E., Jahn O., Siems S. B., Werner H. B., Shomron N., Assaf Y., Peles E., Slutsky I., Marco A. & Barak B. (2025), Nature Communications. 16, 8518

The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution

Sebé-Pedrós A., Tanay A., Lawniczak M. K., Arendt D., Aerts S., Archibald J., Arnone M. I., Blaxter M., Cleves P., Coelho S. M., Dias M., Dunn C., Elek A., Frazer J., Gabaldón T., Gillis J., Grau-Bové X., Guigó R., Hobert O. & Huerta-Cepas J. (2025), Nature. 645, 8082, p. 877-885

Disruption of the developmental factor Otp in the adult forebrain reveals its diverse physiological functions

Tahor M., Kuperman Y., Nahum T., Tsoory M., Bejar B., Regev E., Blechman J., Biran J., Chen A. & Levkowitz G. (2025), BioRxiv

Fibro predict a machine learning risk score for advanced liver fibrosis in the general population using Israeli electronic health records

Kalka I. N., Hazzan R., Yacovzada N. S., Igbaria S., Segal E., Weinberger A. & Neeman Z. (2025), Scientific Reports. 15, 32035

Long-term Hyperbaric Oxygen Treatment Enhances Nerve Regeneration and Remyelination in a Rat Sciatic Nerve Graft Model

Kedar D. J., Shani N., Fliss E., Bracha G., Zvi E., Rosen R., Greenberg O., Eshed Eisenbach Y., Peles E. & Gur E. (2025), Plastic and Reconstructive Surgery - Global Open. 13, 8, p. e7039

The Nodes of Ranvier: Mechanisms of Assembly and Maintenance

Rasband M. N. & Peles E. (2025), Cold Spring Harbor perspectives in biology. 17, 8, a041361

Immune surveillance of senescent cells in aging and disease

Majewska J. & Krizhanovsky V. (2025), Nature Aging. 5, p. 1415-1424

Hyperbaric Oxygen Therapy for PTSD: Threshold Effect for Sustained Symptom Improvement in a Biologically Based Treatment

Danan D., Grosskopf Y., Mayo A., Efrati S., Kutz I., Lang E., Alon U. & Doenyas-Barak K. (2025), Brain and Behavior. 15, 8, e70757

RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells

Peleg S., Zamashanski L., Belin J., Novoselsky R., Cohen-Fultheim R., Knebel U. E., Glaser B., Itzkovitz S., Kaestner K. H., Powers A. C., Levanon E. Y., Klochendler A. & Dor Y. (2025), Molecular Metabolism. 98, 102183

Multimodal AI correlates of glucose spikes in people with normal glucose regulation, pre-diabetes and type 2 diabetes

Carletti M., Pandit J., Gadaleta M., Chiang D., Delgado F., Quartuccio K., Fernandez B., Raygoza Garay J. A., Torkamani A., Miotto R., Rossman H., Berk B., Baca-Motes K., Kheterpal V., Segal E., Topol E. J., Ramos E. & Quer G. (2025), Nature Medicine. 31, 9, p. 3121-3127

Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single-cell RNA sequencing

Somech E., Halder D., Spitzer A., Barbolin C., Tyler M., Halperin R., Biton M., Tirosh A. & Tirosh I. (2025), eLife. 13, RP101153

Deep phenotyping of health-disease continuum in the Human Phenotype Project

Reicher L., Shilo S., Godneva A., Lutsker G., Zahavi L., Shoer S., Krongauz D., Rein M., Kohn S., Segev T., Schlesinger Y., Barak D., Levine Z., Keshet A., Shaulitch R., Lotan-Pompan M., Elkan M., Talmor-Barkan Y., Aviv Y., Dadiani M., Tsodyks Y., Gal-Yam E. N., Leibovitzh H., Werner L., Tzadok R., Maharshak N., Koga S., Glick-Gorman Y., Stossel C., Raitses-Gurevich M., Golan T., Dhir R., Reisner Y., Weinberger A., Rossman H., Song L., Xing E. P. & Segal E. (2025), Nature Medicine. 31, 9, p. 3191-3203

Generative AI enables medical image segmentation in ultra low-data regimes

Zhang L., Jindal B., Alaa A., Weinreb R., Wilson D., Segal E., Zou J. & Xie P. (2025), Nature Communications. 16, 6486

Mapping circulating hematopoietic stem cells for non-invasive, blood-based diagnostics

Furer N. & Shlush L. (2025), Nature Medicine

Crohns disease and ulcerative colitis exhibit prediagnostic antibody signatures with shared and divergent changes towards disease onset

Bourgonje A. R., Andreu-Sánchez S., Gacesa R., Innocenti G., Kalka I. N., Klompus S., Leviatan S., Schlesinger Y., Krongauz D., Weinberger A., Van Der Vegt B., Fu J., Segal E., Zhernakova A., Vogl T. & Weersma R. K. (2025), Gut. 74, 12, p. 1977-1988, 334362

From bench to business: translating academic advances into industry innovations

Abilez O. J., Javali A., Jones J., Rellán-Álvarez R., Sozzani R. & Tzahor E. (2025), Development. 152, 13, dev205007

High-Throughput Single-Cell Proteomics of In Vivo Cells

Karagach S., Smollich J., Atrakchi O., Mohan V. & Geiger T. (2025), Molecular and Cellular Proteomics. 24, 7, 101018

Baseline Characteristics of Weight-Loss Success in a Personalized Nutrition Intervention: A Secondary Analysis

Popp C. J., Wang C., Berube L., Curran M., Hu L., Pompeii M. L., Barua S., Li H., St-Jules D. E., Schoenthaler A., Segal E., Bergman M. & Sevick M. A. (2025), Nutrients. 17, 13, 2178

A reference model of circulating hematopoietic stem cells across the lifespan with applications to diagnostics

Furer N., Rappoport N., Milman O., Tavor S., Lifshitz A., Bercovich A., Ben-Kiki O., Danin A., Kedmi M., Shipony Z., Lipson D., Meiri E., Yanai G., Shapira S., Arber N., Berdichevsky S., Tyner J., Joshi S., Landau D., Ganesan S., Dusaj N., Chamely P., Kaushansky N., Chapal-Ilani N., Shamir R., Tanay A. & Shlush L. (2025), Nature Medicine. 31, 7, p. 2442-2451

A reference model of circulating hematopoietic stem cells across the lifespan with applications to diagnostics

Plasticity in cell adhesion during tumor progression

Saha A. & Ben-Ze'ev A. (2025), Advances in Cancer Research.

Protocol for predicting suppressors of cell-death pathways based on transcriptomic and vulnerability data

Vinik Y., Maimon A. & Lev S. (2025), STAR Protocols. 6, 2, 103855

The Society for Immunotherapy of Cancer Perspective on Liquid Biopsy and Radiomics-Based Technologies for Immuno-oncology Biomarker Discovery and Application

Monette A., Aguilar-Mahecha A., Altinmakas E., Angelos M. G., Assad N., Batist G., Bommareddy P. K., Bonilla D. L., Borchers C. H., Church S. E., Ciliberto G., Cogdill A. P., Fattore L., Hacohen N., Haris M., Lacasse V., Lie W. R., Mehta A., Ruella M., Sater S., Spatz A., Taouli B., Tarhoni I., Gonzalez-Kozlova E., Tirosh I., Wang X. & Gnjatic S. (2025), Clinical Cancer Research. 31, 12, p. 2278-2293

Esophageal microbiome correlates with post-esophagectomy anastomotic leak in cancer patients

Naddaf R., Shmilovich H., Carasso S., Keshet-David R., Herren R., Gefen T., Goshen-Lago T., Zwang Y., Livyatan I., Shental N., Haberfeld O., Straussman R., Markar S. R., Nilsson M., Kashtan H., Ben-Aharon I. & Geva-Zatorsky N. (2025), ESMO Gastrointestinal Oncology. 8, 100172

Curating a single-cell data atlas for a deeper understanding of intra-tumor heterogeneity

Tyler M. & Tirosh I. (2025), Nature Cancer. 6, 6, p. 922-923

Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice

Kim J., Trzebanski S., Shin S., Schori L., Frumer Friedman G. R., Ilani N. C., Kadam A., Vicario R., Aust O., Bugaeva P., Piatek S., Ismajli L. K., Hoffmann C. J., Scheller M., Boura-Halfon S., Kaushansky N., Golani O., Solomon A., Liu Z., Amann L., Böhm-Sturm P., Koch S. P., Wenger N., Ginhoux F., Prinz M., Avraham R., Harms C., Geissmann F., Müller-Tidow C., Uderhardt S., Milenkovic I., Shlush L. & Jung S. (2025), Cell Reports. 44, 5, 115609

Erratum: Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma (Cancer Cell (2021) 39(6) (779792.e11), (S1535610821002683), (10.1016/j.ccell.2021.05.002))

Hara T., Chanoch-Myers R., Mathewson N. D., Myskiw C., Atta L., Bussema L., Eichhorn S. W., Greenwald A. C., Kinker G. S., Rodman C., Gonzalez Castro L. N., Wakimoto H., Rozenblatt-Rosen O., Zhuang X., Fan J., Hunter T., Verma I. M., Wucherpfennig K. W., Regev A., Suvà M. L. & Tirosh I. (2025), Cancer Cell. 43, 6, p. 1175-1176

Characterizing the metabolome of children with growth hormone deficiency

Shilo S., Keshet A., Halloun R., Bar N., Cohen M., Gal S., Oren M., Glantz-Gashai Y., Malitsky S., Itkin M., Lotan-Pompan M., Godneva A., Weinberger A., Tiosano D. & Segal E. (2025), Journal of Pediatric Endocrinology and Metabolism. 38, 8, p. 815-823

Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimers Disease

Villacampa N., Sarlus H., Martorell P., Bhalla K., Gomez-Castro S., Vieira-Saecker A., Slutzkin I., Händler K., Venegas C., McManus R., Ulas T., Beyer M., Segal E. & Heneka M. T. (2025), ASN Neuro. 17, 1, 2506406

Translation dysregulation in cancer as a source for targetable antigens

Weller C., Bartok O., McGinnis C. S., Palashati H., Chang T. G., Malko D., Shmueli M. D., Nagao A., Hayoun D., Murayama A., Sakaguchi Y., Poulis P., Khatib A., Erlanger Avigdor B., Gordon S., Cohen Shvefel S., Zemanek M. J., Nielsen M. M., Boura-Halfon S., Sagie S., Gumpert N., Yang W., Alexeev D., Kyriakidou P., Yao W., Zerbib M., Greenberg P., Benedek G., Litchfield K., Petrovich-Kopitman E., Nagler A., Oren R., Ben-Dor S., Levin Y., Pilpel Y., Rodnina M., Cox J., Merbl Y., Satpathy A. T., Carmi Y., Erhard F., Suzuki T., Buskirk A. R., Olweus J., Ruppin E., Schlosser A. & Samuels Y. (2025), Cancer Cell. 43, 5, p. 823-840.e18

Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics

Spitzer A., Johnson K. C., Nomura M., Garofano L., Nehar-belaid D., Darnell N. G., Greenwald A. C., Bussema L., Oh Y. T., Varn F. S., DAngelo F., Gritsch S., Anderson K. J., Migliozzi S., Gonzalez Castro L. N., Chowdhury T., Robine N., Reeves C., Park J. B., Lipsa A., Hertel F., Golebiewska A., Niclou S. P., Nusrat L., Kellet S., Das S., Moon H. E., Paek S. H., Bielle F., Laurenge A., Di Stefano A. L., Mathon B., Picca A., Sanson M., Tanaka S., Saito N., Ashley D. M., Keir S. T., Ligon K. L., Huse J. T., Yung W. K., Lasorella A., Iavarone A., Verhaak R. G., Tirosh I. & Suvà M. L. (2025), Nature Genetics. 57, 5, p. 1168-1178, 1088

The multilayered transcriptional architecture of glioblastoma ecosystems

Nomura M., Spitzer A., Johnson K. C., Garofano L., Nehar-belaid D., Galili Darnell N., Greenwald A. C., Bussema L., Oh Y. T., Varn F. S., DAngelo F., Gritsch S., Anderson K. J., Migliozzi S., Gonzalez Castro L. N., ChowdhFury T., Robine N., Reeves C., Park J. B., Lipsa A., Hertel F., Golebiewska A., Niclou S. P., Nusrat L., Kellet S., Das S., Moon H. E., Paek S. H., Bielle F., Laurenge A., Di Stefano A. L., Mathon B., Picca A., Sanson M., Tanaka S., Saito N., Ashley D. M., Keir S. T., Ligon K. L., Huse J. T., Yung W. K., Lasorella A., Verhaak R. G., Iavarone A., Suvà M. L. & Tirosh I. (2025), Nature Genetics. 57, 5, p. 1155-1167, 3406

The Curated Cancer Cell Atlas provides a comprehensive characterization of tumors at single-cell resolution

Tyler M., Gavish A., Barbolin C., Tschernichovsky R., Hoefflin R., Mints M., Puram S. V. & Tirosh I. (2025), Nature Cancer. 6, 6, p. 1088-1101

Proteomic and lipidomic analysis of low-density lipoprotein identifies potential biomarkers of early estrogen receptor-positive breast cancer

Abu Mohsen Y., Twitto-Greenberg R., Cohen A., Leichner G. S., Mahler L., Cohen H., Kamari Y., Shaish A., Harari A., Leikin-Frenkel A., Glick Saar E., Geiger T., Malitsky S., Itkin M., Harats D. & Keshet R. (2025), Cancer & Metabolism. 13, 20

Accurate estimation of intraspecific microbial gene content variation in metagenomic data with MIDAS v3 and StrainPGC

Smith B. J., Zhao C., Dubinkina V., Jin X., Zahavi L., Shoer S., Moltzau-Anderson J., Segal E. & Pollard K. S. (2025), Genome Research. 35, 5, p. 1247-1260

GMP-like and MLP-like Subpopulations of Hematopoietic Stem and Progenitor Cells Harboring Mutated EZH2 and TP53 at Diagnosis Promote Acute Myeloid Leukemia Relapse: Data of Combined Molecular, Functional, and Genomic Single-Stem-Cell Analyses

Shahar Gabay T., Stolero N., Rabhun N., Sabah R., Raz O., Neumeier Y., Marx Z., Tao L., Biezuner T., Amir S., Adar R., Levy R., Chapal-Ilani N., Evtiugina N., Shlush L. I., Shapiro E., Yehudai-Resheff S. & Zuckerman T. (2025), International Journal of Molecular Sciences. 26, 9, 4224

Precision nutrition for cardiometabolic diseases

Guasch-Ferré M., Wittenbecher C., Palmnäs M., Ben-Yacov O., Blaak E. E., Dahm C. C., Fall T., Heitmann B. L., Licht T. R., Löf M., Loos R., Patel C. J., Quarta C., Redman L. M., Segal E., Segata N., Snyder M., Sun Q., Tobias D. K., Hu F. B., Franks P. W., Landberg R., Sargent J. L. & Merino J. (2025), Nature Medicine. 31, 5, p. 1444-1453

ARID5A promotes inflammation and fibrosis during cardiac aging: Cardiac aging

Miyara S. & Tzahor E. (2025), Nature Cardiovascular Research. 4, 5, p. 508-510

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Dadiani M., Friedlander G., Perry G., Balint-Lahat N., Gilad S., Morzaev-Sulzbach D., Shenoy A., Bossel Ben-Moshe N., Pavlovsky A., Bernstein-Molho R., Domany E., Barshack I., Geiger T., Kaufman B. & Gal-Yam E. N. (2025), Molecular Oncology

Development of antibiotic resistome in premature infants

Keshet A., Hochwald O., Lavon A., Borenstein-Levin L., Shoer S., Godneva A., Glantz-Gashai Y., Cohen-Dolev N., Timstut F., Lotan-Pompan M., Solt I., Weinberger A., Segal E. & Shilo S. (2025), Cell Reports. 44, 4, 115515

Deciphering the complex clonal heterogeneity of polycythemia vera and the response to interferon alfa

Kalmer M., Grasshoff M., Maié T., Pannen K., Toledo M. A., Vieri M., Olschok K., Lemanzyk R., Lazarevic J., Junge B., Baumeister J., Galauner A., Ilani N. C., Bar D., Colin E., Cheng M., Schifflers J., Kricheldorf K., Schemionek M., Brümmendorf T. H., Weiskirchen R., Shlush L., Zenke M., Chatain N., Costa I. G. & Koschmieder S. (2025), Blood advances. 9, 8, p. 1873-1887

Re-epithelialization of cancer cells increases autophagy and DNA damage: Implications for breast cancer dormancy and relapse

Drago-Garcia D., Giri S., Chatterjee R., Simoni-Nieves A., Abedrabbo M., Genna A., Uribe Rios M. L., Lindzen M., Sekar A., Gupta N., Aharoni N., Bhandari T., Mayalagu A., Schwarzmüller L., Tarade N., Zhu R., Mohan-Raju H. R., Karatekin F., Roncato F., Eyal-Lubling Y., Keidar T., Nof Y., Nataraj N. B., Bernshtein K. S., Wagner B., Nair N. U., Sanghvi N., Alon R., Seger R., Pikarsky E., Donzelli S., Blandino G., Wiemann S., Lev S., Prywes R., Barkan D., Rueda O. M., Caldas C., Ruppin E., Shiloh Y., Dahlhoff M. & Yarden Y. (2025), Science Signaling. 18, 883, eado3473

Neuropeptide oxytocin facilitates its own brain-to-periphery uptake

Rajamannar P., Blechman J., Raz O. & Levkowitz G. (2025), Cell Reports. 44, 4, 115491

Preventing Multimer Formation in Commonly Used Synthetic Biology Plasmids

Vaisbourd E., Bren A., Alon U. & Glass D. S. (2025), ACS Synthetic Biology. 14, 4, p. 1309-1315

A single-cell atlas of Schwannoma across genetic backgrounds and anatomic locations

Gonzalez Castro L. N., Gavish A., Bussema L., Mount C. W., Neftel C., Nomura M., Chiocca E. A., Bi W. L., Arnaout O., Barker F. G., Brown J. M., Jordan J. T., Batchelor T. T., Stemmer-Rachamimov A., Plotkin S. R., Tirosh I. & Suvà M. L. (2025), Genome Medicine. 17, 37

Compression of morbidity by interventions that steepen the survival curve

Yang Y., Mayo A., Levy T., Raz N., Shenhar B., Jarosz D. F. & Alon U. (2025), Nature Communications. 16, 3340

End-User Confidence in Artificial Intelligence-Based Predictions Applied to Biomedical Data

Kam Z., Peracchio L. & Nicora G. (2025), International Journal of Neural Systems. 35, 4, 2550017

Metabolic interplays between the tumour and the host shape the tumour macroenvironment

Altea-Manzano P., Decker-Farrell A., Janowitz T. & Erez A. (2025), Nature Reviews Cancer. 25, 4, p. 274-292, 387014

Clinical translation of microbiome research

Gilbert J. A., Azad M. B., Bäckhed F., Blaser M. J., Byndloss M., Chiu C. Y., Chu H., Dugas L. R., Elinav E., Gibbons S. M., Gilbert K. E., Henn M. R., Ishaq S. L., Ley R. E., Lynch S. V., Segal E., Spector T. D., Strandwitz P., Suez J., Tropini C., Whiteson K. & Knight R. (2025), Nature Medicine. 31, 4, p. 1099-1113

Pregnancy and postpartum dynamics revealed by millions of lab tests

Bar A., Moran R., Mendelsohn-Cohen N., Kohanim Y. K., Mayo A., Toledano Y. & Alon U. (2025), Science Advances. 11, 13, eadr7922

High-dimensional imaging using combinatorial channel multiplexing and deep learning

Ben-Uri R., Ben Shabat L., Shainshein D., Bar-Tal O., Bussi Y., Maimon N., Keidar Haran T., Milo I., Goliand I., Addadi Y., Salame T. M., Rochwarger A., Schürch C. M., Bagon S., Elhanani O. & Keren L. (2025), Nature Biotechnology, eaar7042

Cold and hot fibrosis define clinically distinct cardiac pathologies

Miyara S., Adler M., Umansky K. B., Häußler D., Bassat E., Divinsky Y., Elkahal J., Kain D., Lendengolts D., Ramirez Flores R. O., Bueno-Levy H., Golani O., Shalit T., Gershovits M., Weizman E., Genzelinakh A., Kimchi D. M., Shakked A., Zhang L., Wang J., Baehr A., Petrover Z., Sarig R., Dorn T., Moretti A., Saez-Rodriguez J., Kupatt C., Tanaka E. M., Medzhitov R., Krüger A., Mayo A., Alon U. & Tzahor E. (2025), Cell Systems. 16, 3, 101198

Cold and hot fibrosis define clinically distinct cardiac pathologies

Hormone circuit explains why most HPA drugs fail for mood disorders and predicts the few that work

Milo T., Nir Halber S., Raz M., Danan D., Mayo A. & Alon U. (2025), Molecular Systems Biology. 21, 3, p. 254-273, 18

Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma

Shvefel S. C., Pai J. A., Cao Y., Pal L. R., Bartok O., Levy R., Zemanek M. J., Weller C., Herzog E., Yao W., Hiam-Galvez K. J., Cheng K., Yin Y., Du P. P., Raposo C. J., Gumpert N., Welti M., Martínez Gómez J. M., Sella F., Yakubovich E., Orr I., Ben-Dor S., Oren R., Fellus-Alyagor L., Golani O., Brenner O. J., Salame T. M., Zerbib M., Goliand I., Ranmar D., Savchenko I., Ketrarou N., Schäffer A. A., Dahan R., Levesque M. P., Ruppin E., Satpathy A. T. & Samuels Y. (2025), Cancer Discovery. 15, 3, p. 553-577

Phenome-wide associations of sleep characteristics in the Human Phenotype Project

Kohn S., Diament A., Godneva A., Dhir R., Weinberger A., Reisner Y., Rossman H. & Segal E. (2025), Nature Medicine. 31, 3, p. 1026-1037, 4881
Submitted Version

Members of the DIP and Dpr adhesion protein families use cis inhibition to shape neural development in Drosophila

Morano N. C., Lopez D. H., Meltzer H., Sergeeva A. P., Katsamba P. S., Rostam K. D., Gupta H. P., Becker J. E., Bornstein B., Cosmanescu F., Schuldiner O., Honig B., Mann R. S. & Shapiro L. (2025), PLoS Biology. 23, 3, e3003030

Emerging clinical applications of single-cell RNA sequencing in oncology

Boxer E., Feigin N., Tschernichovsky R., Darnell N. G., Greenwald A. R., Hoefflin R., Kovarsky D., Simkin D., Turgeman S., Zhang L. & Tirosh I. (2025), Nature Reviews Clinical Oncology. 22, 5, p. 315-326, 2285

What is the main bottleneck in deriving biological understanding from spatial transcriptomic profiling?

Moffitt J. R., Li M., Nie Q., Kanemaru K., Teichmann S. A., Dar D., Kagohara L. T., Itzkovitz S., Vento-Tormo R., Yanai I., Fertig E. J. & Theis F. J. (2025), Cell Systems. 16, 2, 101200

A journal that promotes excellence through uncompromising review process: Reflection of freedom of speech and scientific publication

Kam Z. & Nicora G. (2025), International Journal of Neural Systems, 2502001

The Society for Immunotherapy of Cancer Perspective on Tissue-Based Technologies for Immuno-Oncology Biomarker Discovery and Application

Monette A., Aguilar-Mahecha A., Altinmakas E., Angelos M. G., Assad N., Batist G., Bommareddy P. K., Bonilla D. L., Borchers C. H., Church S. E., Ciliberto G., Cogdill A. P., Fattore L., Hacohen N., Haris M., Lacasse V., Lie W. R., Mehta A., Ruella M., Sater H. A., Spatz A., Taouli B., Tarhoni I., Gonzalez-Kozlova E., Tirosh I., Wang X. & Gnjatic S. (2025), Clinical Cancer Research. 31, 3, p. 439-456

International consensus statement on microbiome testing in clinical practice

Porcari S., Mullish B. H., Asnicar F., Ng S. C., Zhao L., Hansen R., O'Toole P. W., Raes J., Hold G., Putignani L., Hvas C. L., Zeller G., Koren O., Tun H., Valles-Colomer M., Collado M. C., Fischer M., Allegretti J., Iqbal T., Chassaing B., Keller J., Baunwall S. M., Abreu M., Barbara G., Zhang F., Ponziani F. R., Costello S. P., Paramsothy S., Kao D., Kelly C., Kupcinskas J., Youngster I., Franceschi F., Khanna S., Vehreschild M., Link A., De Maio F., Pasolli E., Miguez A. B., Brigidi P., Posteraro B., Scaldaferri F., Stojanovic M. R., Megraud F., Malfertheiner P., Masucci L., Arumugam M., Kaakoush N., Segal E., Bajaj J., Leong R., Cryan J., Weersma R. K., Knight R., Guarner F., Shanahan F., Cani P. D., Elinav E., Sanguinetti M., de Vos W. M., El-Omar E., Dorè J., Marchesi J., Tilg H., Sokol H., Segata N., Cammarota G., Gasbarrini A. & Ianiro G. (2025), The Lancet Gastroenterology and Hepatology. 10, 2, p. 154-167
Submitted Version

GD3 ganglioside checkpoints in immune surveillance of senescent cells: Immune surveillance

Majewska J. & Krizhanovsky V. (2025), Nature Aging. 5, 2, p. 182-183, 5435

Glioblastoma Cortical Organoids Recapitulate Cell-State Heterogeneity and Intercellular Transfer

Mangena V., Chanoch-Myers R., Sartore R., Paulsen B., Gritsch S., Weisman H., Hara T., Breakefield X. O., Breyne K., Regev A., Chung K., Arlotta P., Tirosh I. & Suvà M. L. (2025), Cancer Discovery. 15, 2, p. 299-315

Oncogenic IDH1mut drives robust loss of histone acetylation and increases chromatin heterogeneity

Furth N., Cohen N., Spitzer A., Salame T. M., Dassa B., Mehlman T., Brandis A., Moussaieff A., Friedmann-Morvinski D., Castro M. G., Fortin J., Suvà M. L., Tirosh I., Erez A., Ron G. & Shema E. (2025), Proceedings of the National Academy of Sciences - PNAS. 122, 1, e240386212

Oncogenic IDH1mut drives robust loss of histone acetylation and increases chromatin heterogeneity

2024

Age-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG

Ding X., Wu Y., Vainshtein A., Rodriguez V., Ricco E., Okoh J. T., Liu Y., Kraushaar D. C., Peles E. & Rasband M. N. (2024), Nature Communications. 15, 10865

Utilizing insights of DNA repair machinery to discover MMEJ deletions and novel mechanisms

Kadam A., Shilo S., Naor H., Wainstein A., Brilon Y., Feldman T., Minden M., Kaushansky N., Chapal-Ilani N. & Shlush L. (2024), Nucleic Acids Research. 52, 22, e106

Multiplexed image analysis: what have we achieved and where are we headed?

Bussi Y. & Keren L. (2024), Nature Methods. 21, p. 2212-2215

Intracellular polarization of RNAs and proteins in the human small intestinal epithelium

Novoselsky R., Harnik Y., Yakubovsky O., Katina C., Levin Y., Halpern K. B., Pencovich N., Nachmany I. & Itzkovitz S. (2024), PLoS Biology. 22, 12, e3002942

Longevity NationEnhancing Research, Development and Education for Healthy Longevity

Stambler I., Lederman S., Olshansky S. J., Cohen H. Y., Schumacher B., Greenfield S., Krizhanovsky V., Grunewald M., Barzilai N., Gonos E. S., Yanay Y., Yivgi-Ohana N., Atzmon G., Bar D. Z., Alon U., Shen-Orr S., Bischof E., Strauss T., Vita-More N., Calabrese V., Kozhokaru A. B., Kyriazis M., Kaminskiy D., Miller F., Trukhanov A., Fraifeld V., Cordeiro J. L. & Faragher R. (2024), Advances in Gerontology. 14, 4, p. 151-160

Longevity NationEnhancing Research, Development and Education for Healthy Longevity

Crosslinking of Ly6a metabolically reprograms CD8 T cells for cancer immunotherapy

Maliah A., Santana-Magal N., Parikh S., Gordon S., Reshef K., Sade Y., Khateeb A., Richter A., Gutwillig A., Parikh R., Golan T., Krissi M., Na M., Binshtok G., Manich P., Elkoshi N., Grisaru-Tal S., Zemser-Werner V., Brenner R., Vaknine H., Nizri E., Moyal L., Amitay-Laish I., Rosemberg L., Munitz A., Kronfeld-Schor N., Shifrut E., Kobiler O., Madi A., Geiger T., Carmi Y. & Levy C. (2024), Nature Communications. 15, 8354

The oncogenic axis YAP/MYC/EZH2 impairs PTEN tumor suppression activity enhancing lung tumorigenicity

Lo Sardo F., Turco C., Messina B., Sacconi A., Auciello F. R., Pulito C., Strano S., Lev S. & Blandino G. (2024), Cell Death Discovery. 10, 1, 452

Immune organization in sentinel lymph nodes of melanoma patients is prognostic of distant metastases

Amitay Y., Milo I., Keidar Haran T., Deis S., Truzman G., Elhanani O., Salame T., Azimov M., Stein I., Cohen J. E., Lotem M., Pikarsky E. & Keren L. (2024), BioRxiv

A modular protein language modelling approach to immunogenicity prediction

OBrien H., Salm M., Morton L. T., Szukszto M., OFarrell F., Boulton C., King L., Bola S. K., Becker P. D., Craig A., Nielsen M., Samuels Y., Swanton C., Mansour M. R., Hadrup S. R. & Quezada S. A. (2024), PLoS Computational Biology. 20, 11, e1012511

Sex-specific dietary habits and their association with weight change in healthy adults

Rein M., Elkan M., Godneva A., Dolev N. C. & Segal E. (2024), BMC Medicine. 22, 512

Phenome-wide associations of human aging uncover sex-specific dynamics

Reicher L., Bar N., Godneva A., Reisner Y., Zahavi L., Shahaf N., Dhir R., Weinberger A. & Segal E. (2024), Nature Aging. 4, 11, p. 1643-1655

Graham A. Dunn (1944-2024) - a pioneer of cell migration analysis

Jones G. E. & Bershadsky A. (2024), Journal of Cell Science. 137, 21

A Necessary Role for Cyclin D2 Induction During Colon Cancer Progression Mediated by L1

Saha A., Gavert N., Brabletz T. & Ben-Zeev A. (2024), Cells. 13, 21, 1810

Identification of gut microbiome features associated with host metabolic health in a large population-based cohort

Keshet A. & Segal E. (2024), Nature Communications. 15, 9358

Temporal BMP4 effects on mouse embryonic and extraembryonic development

Hadas R., Rubinstein H., Mittnenzweig M., Mayshar Y., Ben-Yair R., Cheng S., Aguilera-Castrejon A., Reines N., Orenbuch A., Lifshitz A., Chen D., Elowitz M. B., Zernicka-Goetz M., Hanna J. H., Tanay A. & Stelzer Y. (2024), Nature. 634, 8034, p. 652-661

Temporal BMP4 effects on mouse embryonic and extraembryonic development

TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not Axon Specification or Axon Initial Segment Formation

Melton A. J., Palfini V. L., Ogawa Y., Oses Prieto J. A., Vainshtein A., Burlingame A. L., Peles E. & Rasband M. N. (2024), Journal of Neuroscience. 44, 42, e097624202

Pangenomes of human gut microbiota uncover links between genetic diversity and stress response

Shoer S., Reicher L., Zhao C., Pollard K. S., Pilpel Y. & Segal E. (2024), Cell Host and Microbe. 32, 10, p. 1744-1757.e2
Submitted Version

Multidirectional Filamented Light Biofabrication Creates Aligned and Contractile Cardiac Tissues

Jones L. S., Filippi M., Michelis M. Y., Balciunaite A., Yasa O., Aviel G., Narciso M., Freedrich S., Generali M., Tzahor E. & Katzschmann R. K. (2024), Advanced Science. 11, 47, 2404509

p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb

Papismadov N., Levi N., Roitman L., Agrawal A., Ovadya Y., Cherqui U., Yosef R., Akiva H., Gal H. & Krizhanovsky V. (2024), EMBO Journal. 43, 22, p. 5360-5380

Computational pipeline predicting cell death suppressors as targets for cancer therapy

Vinik Y., Maimon A., Mohan Raju H. R., Dubey V., Geist F., Wienke D. & Lev S. (2024), iScience. 27, 9, 110859

Endocrine gland size is proportional to its target tissue size

Raz M., Milo T., Glass D. S., Mayo A. & Alon U. (2024), iScience. 27, 9, 110625

Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment

Schmidt D., Endres C., Hoefflin R., Andrieux G., Zwick M., Karantzelis N., Staehle H. F., Vinnakota J. M., Duquesne S., Jovein M. M., Pfeifer D., Becker H., Blazar B. R., Zähringer A., Duyster J., Brummer T., Boerries M., Baumeister J., Shoumariyeh K., Li J., Green A. R., Heidel F. H., Tirosh I., Pahl H. L., Leimkühler N., Köhler N., de Toledo M. A., Koschmieder S. & Zeiser R. (2024), Cancer Research. 84, 18, p. 2985-3003
Submitted Version

Cancer cell states: Lessons from ten years of single-cell RNA-sequencing of human tumors

Tirosh I. & Suva M. L. (2024), Cancer Cell. 42, 9, p. 1497-1506

A spatial atlas of human gastro-intestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology

Azulay N., Milo I., Bussi Y., Uri R. B., Haran T. K., Eldar M., Elhanani O., Harnik Y., Yakubovsky O., Nachmany I., Salame T., Wartenberg M., Bertheau P., Michonneau D., Socie G. & Keren L. (2024), BioRxiv

Repurposing of glatiramer acetate to treat cardiac ischemia in rodent models

Aviel G., Elkahal J., Umansky K. B., Bueno-Levy H., Petrover Z., Kotlovski Y., Lendengolts D., Kain D., Shalit T., Zhang L., Miyara S., Kramer M. P., Merbl Y., Kozlovski S., Alon R., Aharoni R., Arnon R., Mishali D., Katz U., Nachman D., Asleh R., Amir O., Tzahor E. & Sarig R. (2024), Nature Cardiovascular Research. 3, 9, p. 1049-1066

Ferroptosis in health and disease

Berndt C., Alborzinia H., Amen V. S., Ayton S., Barayeu U., Bartelt A., Bayir H., Bebber C. M., Birsoy K., Böttcher J. P., Brabletz S., Brabletz T., Brown A. R., Brüne B., Bulli G., Bruneau A., Chen Q., DeNicola G. M., Dick T. P., Distéfano A., Dixon S. J., Engler J. B., Esser-von Bieren J., Fedorova M., Friedmann Angeli J. P., Friese M. A., Fuhrmann D. C., García-Sáez A. J., Garbowicz K., Götz M., Gu W., Hammerich L., Hassannia B., Jiang X., Jeridi A., Kang Y. P., Kagan V. E., Konrad D. B., Kotschi S., Lei P., Le Tertre M., Lev S., Liang D., Linkermann A., Lohr C., Lorenz S., Luedde T., Methner A., Michalke B., Milton A. V., Min J., Mishima E., Müller S., Motohashi H., Muckenthaler M. U., Murakami S., Olzmann J. A., Pagnussat G., Pan Z., Papagiannakopoulos T., Pedrera Puentes L., Pratt D. A., Proneth B., Ramsauer L., Rodriguez R., Saito Y., Schmidt F., Schmitt C., Schulze A., Schwab A., Schwantes A., Soula M., Spitzlberger B., Stockwell B. R., Thewes L., Thorn-Seshold O., Toyokuni S., Tonnus W., Trumpp A., Vandenabeele P., Vanden Berghe T., Venkataramani V., Vogel F. C., von Karstedt S., Wang F., Westermann F., Wientjens C., Wilhelm C., Wölk M., Wu K., Yang X., Yu F., Zou Y. & Conrad M. (2024), Redox Biology. 75, 103211

A spatial expression atlas of the adult human proximal small intestine

Harnik Y., Yakubovsky O., Hoefflin R., Novoselsky R., Bahar Halpern K., Barkai T., Korem Kohanim Y., Egozi A., Golani O., Addadi Y., Kedmi M., Keidar Haran T., Levin Y., Savidor A., Keren-Shaul H., Mayer C., Pencovich N., Pery R., Shouval D. S., Tirosh I., Nachmany I. & Itzkovitz S. (2024), Nature. 632, 8027, p. 1101-1109

A spatial expression atlas of the adult human proximal small intestine

Cohort profile: Study design and baseline characteristics of an observational longitudinal weight loss cohort and biorepository of patients undergoing sleeve gastrectomy in the USA

Vanegas S. M., Curado S., Gujral A., Valverde G., Parraga S., Aleman J. O., Reid M., Elbel B., Schmidt A. M., Heffron S. P., Segal E., Li H., Abrams C., Sevick M. A., Popp C., Armijos E., Merriwether E. N., Ivezaj V., Ren-Fielding C., Parikh M. & Jay M. (2024), BMJ Open. 14, 8, e081201

Probing PAC1 receptor activation across species with an engineered sensor

Cola R. B., Niethammer S. N., Rajamannar P., Gresch A., Bhat M. A., Assoumou K., Williams E. T., Hauck P., Hartrampf N., Benke D., Stoeber M., Levkowitz G., Melzer S. & Patriarchi T. (2024), eLife. 13, RP96496

Guidelines for minimal information on cellular senescence experimentation in vivo

Ogrodnik M., Carlos Acosta J., Adams P. D., d'Adda di Fagagna F., Baker D. J., Bishop C. L., Chandra T., Collado M., Gil J., Gorgoulis V., Gruber F., Hara E., Jansen-Dürr P., Jurk D., Khosla S., Kirkland J. L., Krizhanovsky V., Minamino T., Niedernhofer L. J., Passos J. F., Ring N. A., Redl H., Robbins P. D., Rodier F., Scharffetter-Kochanek K., Sedivy J. M., Sikora E., Witwer K., von Zglinicki T., Yun M. H., Grillari J. & Demaria M. (2024), Cell. 187, 16, p. 4150-4175

Targeting of mutant-p53 and MYC as a novel strategy to inhibit oncogenic SPAG5 activity in triple negative breast cancer

Canu V., Vaccarella S., Sacconi A., Pulito C., Goeman F., Pallocca M., Rutigliano D., Lev S., Strano S. & Blandino G. (2024), Cell Death and Disease. 15, 603

p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells

Majewska J., Agrawal A., Mayo A., Roitman L., Chatterjee R., Sekeresova Kralova J., Landsberger T., Katzenelenbogen Y., Meir-Salame T., Hagai E., Sopher I., Perez-Correa J. F., Wagner W., Maimon A., Amit I., Alon U. & Krizhanovsky V. (2024), Nature Cell Biology. 26, 8, p. 1336-1345

p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells

Egr1 regulates regenerative senescence and cardiac repair

Zhang L., Elkahal J., Wang T., Rimmer R., Genzelinakh A., Bassat E., Wang J., Perez D., Kain D., Lendengolts D., Winkler R., Bueno-levy H., Umansky K. B., Mishaly D., Shakked A., Miyara S., Sarusi-Portuguez A., Goldfinger N., Prior A., Morgenstern D., Levin Y., Addadi Y., Li B., Rotter V., Katz U., Tanaka E. M., Krizhanovsky V., Sarig R. & Tzahor E. (2024), Nature Cardiovascular Research. 3, 8, p. 915-932

Egr1 regulates regenerative senescence and cardiac repair

Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer

Bojmar L., Zambirinis C. P., Hernandez J. M., Chakraborty J., Shaashua L., Kim J., Johnson K. E., Hanna S., Askan G., Burman J., Ravichandran H., Zheng J., Jolissaint J. S., Srouji R., Song Y., Choubey A., Kim H. S., Cioffi M., van Beek E., Sigel C., Jessurun J., Velasco Riestra P., Blomstrand H., Jönsson C., Jönsson A., Lauritzen P., Buehring W., Ararso Y., Hernandez D., Vinagolu-Baur J. P., Friedman M., Glidden C., Firmenich L., Lieberman G., Mejia D. L., Nasar N., Mutvei A. P., Paul D. M., Bram Y., Costa-Silva B., Basturk O., Boudreau N., Zhang H., Matei I. R., Hoshino A., Kelsen D., Sagi I., Scherz A., Scherz-Shouval R., Yarden Y., Oren M., Egeblad M., Lewis J. S., Keshari K., Grandgenett P. M., Hollingsworth M. A., Rajasekhar V. K., Healey J. H., Björnsson B., Simeone D. M., Tuveson D. A., Iacobuzio-Donahue C. A., Bromberg J., Vincent C. T., OReilly E. M., DeMatteo R. P., Balachandran V. P., DAngelica M. I., Kingham T. P., Allen P. J., Simpson A. L., Elemento O., Sandström P., Schwartz R. E., Jarnagin W. R. & Lyden D. (2024), Nature Medicine. 30, 8, p. 2170-2180

Diabetes Telemedicine Mediterranean Diet (DiaTeleMed) Study: study protocol for a fully remote randomized clinical trial evaluating personalized dietary management in individuals with type 2 diabetes

Berube L. T., Popp C. J., Curran M., Hu L., Pompeii M. L., Barua S., Bernstein E., Salcedo V., Li H., St-Jules D. E., Segal E., Bergman M., Williams N. J. & Sevick M. A. (2024), Trials. 25, 506

A hybrid epithelial/mesenchymal state in head and neck cancer: A biomarker for survival with differential prognosis by self-reported race

Mazul A. L., Barrett T. F., Colditz G., Parikh A. S., Ramadan S., Zevallos J. P., Rich J. T., Harbison R. A., Jackson R. S., Pipkorn P., Zolkind P., Tirosh I. & Puram S. V. (2024), Med. 5, 7, p. 826-831.e3

Single-cell atlas of the human brain vasculature across development, adulthood and disease

Wälchli T., Ghobrial M., Schwab M., Takada S., Zhong H., Suntharalingham S., Vetiska S., Gonzalez D. R., Wu R., Rehrauer H., Dinesh A., Yu K., Chen E. L., Bisschop J., Farnhammer F., Mansur A., Kalucka J., Tirosh I., Regli L., Schaller K., Frei K., Ketela T., Bernstein M., Kongkham P., Carmeliet P., Valiante T., Dirks P. B., Suva M. L., Zadeh G., Tabar V., Schlapbach R., Jackson H. W., De Bock K., Fish J. E., Monnier P. P., Bader G. D. & Radovanovic I. (2024), Nature. 632, 8025, p. 603-613

ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response

Lim L. Q. J., Adler L., Hajaj E., Soria L. R., Perry R. B. T., Darzi N., Brody R., Furth N., Lichtenstein M., Bab-Dinitz E., Porat Z., Melman T., Brandis A., Aylon Y., Ben-Dor S., Orr I., Pri-Or A., Seger R., Shaul Y., Ruppin E., Oren M., Perez M., Meier J., Brunetti-Pierri N., Shema E., Ulitsky I., Erez A., Malitsky S. & Itkin M. (2024), Nature metabolism. 6, 7, p. 1294-1309

ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response

Expression of modified FcγRI enables myeloid cells to elicit robust tumor-specific cytotoxicity

Farhat-Younis L., Na M., Zarfin A., Khateeb A., Santana-Magal N., Richter A., Gutwillig A., Rasoulouniriana D., Gleiberman A., Beck L., Giger T., Ashkenazi A., Barzel A., Rider P. & Carmi Y. (2024), eLife. 12, RP91999

Identification of senescent, TREM2-expressing microglia in aging and Alzheimers disease model mouse brain

Rachmian N., Medina S., Cherqui U., Akiva H., Deitch D., Edilbi D., Croese T., Salame T. M., Ramos J. M. P., Cahalon L., Krizhanovsky V. & Schwartz M. (2024), Nature Neuroscience. 27, 6, p. 1116-1124
Submitted Version

A snapshot into the transcriptomic landscape of apoptosis and ferroptosis in cancer

Vinik Y. & Lev S. (2024), Cell Death and Disease. 15, 371

BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice

Bongiovanni C., Bueno-Levy H., Posadas Pena D., Del Bono I., Miano C., Boriati S., Da Pra S., Sacchi F., Redaelli S., Bergen M., Romaniello D., Pontis F., Tassinari R., Kellerer L., Petraroia I., Mazzeschi M., Lauriola M., Ventura C., Heermann S., Weidinger G., Tzahor E. & D'Uva G. (2024), Cell Reports. 43, 5, 114162

Focal adhesions are controlled by microtubules through local contractility regulation

Aureille J., Prabhu S. S., Barnett S. F., Farrugia A. J., Arnal I., Lafanechère L., Low B. C., Kanchanawong P., Mogilner A. & Bershadsky A. D. (2024), EMBO Journal. 43, 13, p. 2715-2732

Mutant p53 reactivation restricts the protumorigenic consequences of wild type p53 loss of heterozygosity in Li-Fraumeni syndrome patient-derived fibroblasts

Agarwal H., Tal P., Goldfinger N., Chattopadhyay E., Malkin D., Rotter V. & Attery A. (2024), Cell Death and Differentiation. 31, 7, p. 855-867

Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma

Spitzer A., Gritsch S., Nomura M., Jucht A., Fortin J., Raviram R., Weisman H. R., Gonzalez Castro L. N., Druck N., Chanoch-Myers R., Lee J. J., Mylvaganam R., Lee Servis R., Fung J. M., Lee C. K., Nagashima H., Miller J. J., Arrillaga-Romany I., Louis D. N., Wakimoto H., Pisano W., Wen P. Y., Mak T. W., Sanson M., Touat M., Landau D. A., Ligon K. L., Cahill D. P., Suvà M. L. & Tirosh I. (2024), Cancer Cell. 42, 5, p. 904-914.e9

Integrative spatial analysis reveals a multi-layered organization of glioblastoma

Greenwald A. C., Darnell N. G., Hoefflin R., Simkin D., Mount C. W., Gonzalez Castro L. N., Harnik Y., Dumont S., Hirsch D., Nomura M., Talpir T., Kedmi M., Goliand I., Medici G., Laffy J., Li B., Mangena V., Keren-Shaul H., Weller M., Addadi Y., Neidert M. C., Suvà M. L. & Tirosh I. (2024), Cell. 187, 10, p. 2485-2501.e26
Submitted Version

TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis

Isaac R., Bandyopadhyay G., Rohm T. V., Kang S., Wang J., Pokhrel N., Sakane S., Zapata R., Libster A. M., Vinik Y., Berhan A., Kisseleva T., Borok Z., Zick Y., Telese F., Webster N. J. & Olefsky J. M. (2024), Cell Metabolism. 36, 5, p. 1030-1043.e7

Competitive fungal commensalism mitigates candidiasis pathology

Sekeresova Kralova J., Donic C., Dassa B., Livyatan I., Jansen P. M., Ben-Dor S., Fidel L., Trzebanski S., Narunsky-Haziza L., Asraf O., Brenner O., Dafni H., Jona G., Boura-Halfon S., Stettner N., Segal E., Brunke S., Pilpel Y., Straussman R., Zeevi D., Bacher P., Hube B., Shlezinger N. & Jung S. (2024), Journal of Experimental Medicine. 221, 5, e20231686

Competitive fungal commensalism mitigates candidiasis pathology

Membrane Tilt Drives Phase Separation of Adhesion Receptors

Lin S. Z., Changede R., Farrugia A. J., Bershadsky A. D., Sheetz M. P., Prost J. & Rupprecht J. F. (2024), Physical Review Letters. 132, 18, 188402

The caloric value of food intake structurally adjusts a neuronal mushroom body circuit mediating olfactory learning in Drosophila

Çoban B., Poppinga H., Rachad E. Y., Geurten B., Vasmer D., Jimenez F. J. R., Gadgil Y., Deimel S. H., Alyagor I., Schuldiner O., Grunwald Kadow I. C., Riemensperger T. D., Widmann A. & Fiala A. (2024), Learning and Memory. 31, 5, p. 1-15

Continuous glucose monitoring and intrapersonal variability in fasting glucose

Shilo S., Keshet A., Rossman H., Godneva A., Talmor-Barkan Y., Aviv Y. & Segal E. (2024), Nature Medicine. 30, 5, p. 1424-1431

Modeling T cell temporal response to cancer immunotherapy rationalizes development of combinatorial treatment protocols

Barboy O., Bercovich A., Li H., Lubling Y., Yalin A., Shapir Itai Y., Abadie K., Zada M., David E., Shlomi S., Katzenelenbogen Y., Adhemar D., Gur C., Yofe I., Feferman T., Cohen M., Dahan R., Newell E., Lifshitz A., Tanay A. & Amit I. (2024), Nature Cancer. 5, 5, p. 742-759

ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP

Abbas R., Hartmann O., Asiss D. T., Abbas R., Kagan J., Kim H. T., Oren M., Diefenbacher M., Orian A. & Larisch S. (2024), Apoptosis. 29, 7-8, p. 1145-1160

ATF3 characterizes aggressive drug-tolerant persister cells in HGSOC

Böpple K., Oren Y., Henry W. S., Dong M., Weller S., Thiel J., Kleih M., Gaißler A., Zipperer D., Kopp H. G., Aylon Y., Oren M., Essmann F., Liang C. & Aulitzky W. E. (2024), Cell Death and Disease. 15, 290

Targeting SRSF2 mutations in leukemia with RKI-1447: A strategy to impair cellular division and nuclear structure

Su M., Fleischer T., Grosheva I., Horev M. B., Olszewska M., Mattioli C. C., Barr H., Plotnikov A., Carvalho S., Moskovich Y., Minden M. D., Chapal-Ilani N., Wainstein A., Papapetrou E. P., Dezorella N., Cheng T., Kaushansky N., Geiger B. & Shlush L. I. (2024), iScience. 27, 4, 109443

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

Lü Y. Q., Cho T., Mukherjee S., Suarez C. F., Gonzalez-Foutel N. S., Malik A., Martinez S., Dervovic D., Oh R. H., Langille E., Al-Zahrani K. N., Hoeg L., Lin Z. Y., Tsai R., Mbamalu G., Rotter V., Ashton-Prolla P., Moffat J., Chemes L. B., Gingras A. C., Oren M., Durocher D. & Schramek D. (2024), Molecular Systems Biology. 20, 6, p. 719-740

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro Environments

Hajaj E., Pozzi S. & Erez A. (2024), Cold Spring Harbor perspectives in medicine. 14, 4, a041538

Geroprotective interventions converge on gene expression programs of reduced inflammation and restored fatty acid metabolism

Landsberger T., Amit I. & Alon U. (2024), GeroScience. 46, 2, p. 1627-1639
Submitted Version

Embracing cancer complexity: Hallmarks of systemic disease

Swanton C., Bernard E., Abbosh C., André F., Auwerx J., Balmain A., Bar-Sagi D., Bernards R., Bullman S., DeGregori J., Elliott C., Erez A., Evan G., Febbraio M. A., Hidalgo A., Jamal-Hanjani M., Joyce J. A., Kaiser M., Lamia K., Locasale J. W., Loi S., Malanchi I., Merad M., Musgrave K., Patel K. J., Quezada S., Wargo J. A., Weeraratna A., White E., Winkler F., Wood J. N., Vousden K. H. & Hanahan D. (2024), Cell. 187, 7, p. 1589-1616

p53: A tale of complexity and context

Oren M. & Prives C. (2024), Cell. 187, 7, p. 1569-1573

How Can Young Extracellular Matrix Promote Cardiac Regeneration? Versi-Can!

Bassat E. & Tzahor E. (2024), Circulation. 149, 13, p. 1016-1018

Longitudinal hair cortisol in bipolar disorder and a mechanism based on HPA dynamics

Milo T., Maimon L., Cohen B., Haran D., Segman D., Danon T., Bren A., Mayo A., Rappaport G. C., McInnis M. & Alon U. (2024), iScience. 27, 3, 109234

Programming a Ferroptosis-to-Apoptosis Transition Landscape Revealed Ferroptosis Biomarkers and Repressors for Cancer Therapy

Vinik Y., Maimon A., Dubey V., Raj H., Abramovitch I., Malitsky S., Itkin M., Ma'ayan A., Westermann F., Gottlieb E., Ruppin E. & Lev S. (2024), Advanced Science. 11, 17, 2307263

Age-related micro-environmental changes as drivers of clonal hematopoiesis

Bacharach T., Kaushansky N. & Shlush L. I. (2024), Current Opinion in Hematology. 31, 2, p. 53-57

A synthetic differentiation circuit in Escherichia coli for suppressing mutant takeover

Glass D. S., Bren A., Vaisbourd E., Mayo A. & Alon U. (2024), Cell. 187, 4, p. 931-944.e12
Submitted Version

MinD-RNase E interplay controls localization of polar mRNAs in E. coli

Kannaiah S., Goldberger O., Alam N., Barnabas G., Pozniak Y., Nussbaum-Shochat A., Schueler-Furman O., Geiger T. & Amster-Choder O. (2024), EMBO Journal. 43, 4, p. 637-662

Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains

Zwick R. K., Kasparek P., Palikuqi B., Viragova S., Weichselbaum L., McGinnis C. S., McKinley K. L., Rathnayake A., Vaka D., Nguyen V., Trentesaux C., Reyes E., Gupta A. R., Gartner Z. J., Locksley R. M., Gardner J. M., Itzkovitz S., Boffelli D. & Klein O. D. (2024), Nature Cell Biology. 26, 2, p. 250-262

Quantification of beta cell carrying capacity in prediabetes

Woller A., Tamir Y., Bar A., Mayo A., Rein M., Godneva A., Cohen N. M., Segal E., Toledano Y., Shilo S., Gonze D. & Alon U. (2024), BioRxiv

Quantification of beta cell carrying capacity in prediabetes

Woller A., Tamir Y., Bar A., Mayo A., Rein M., Godneva A., Cohen N. M., Segal E., Toledano Y., Shilo S., Gonze D. & Alon U. (2024), BioRxiv

Immune profiling and tracking of two-dimensional transition metal dichalcogenides in cells and tissues

Gazzi A., Fusco L., Orecchioni M., Keshavan S., Shin Y., Grivel J. C., Rinchai D., Ahmed E. I., Elhanani O., Furesi G., Rauner M., Keren L., Ley K., Casiraghi C., Bedognetti D., Fadeel B. & Delogu L. G. (2024), Nano Today. 54, 102084

Endocrinology in the multi-omics era

Shilo S. & Segal E. (2024), Nature Reviews Endocrinology. 20, 2, p. 73-74

Bispecific dendritic-T cell engager potentiates anti-tumor immunity

Shapir Itai Y., Barboy O., Salomon R., Bercovich A., Xie K., Winter E., Shami T., Porat Z., Erez N., Tanay A., Amit I. & Dahan R. (2024), Cell. 187, 2, p. 375-389.e18

Genome-wide association studies and polygenic risk score phenome-wide association studies across complex phenotypes in the human phenotype project

Levine Z., Kalka I., Kolobkov D., Rossman H., Godneva A., Shilo S., Keshet A., Weissglas-Volkov D., Shor T., Diament A., Talmor-Barkan Y., Aviv Y., Sharon T., Weinberger A. & Segal E. (2024), Med. 5, 1, p. 90-101.e4
Submitted Version

Melanoma and microbiota: Current understanding and future directions

Routy B., Jackson T., Mählmann L., Baumgartner C. K., Blaser M., Byrd A., Corvaia N., Couts K., Davar D., Derosa L., Hang H. C., Hospers G., Isaksen M., Kroemer G., Malard F., McCoy K. D., Meisel M., Pal S., Ronai Z., Segal E., Sepich-Poore G. D., Shaikh F., Sweis R. F., Trinchieri G., van den Brink M., Weersma R. K., Whiteson K., Zhao L., McQuade J., Zarour H. & Zitvogel L. (2024), Cancer Cell. 42, 1, p. 16-34

Longitudinal machine learning uncouples healthy aging factors from chronic disease risks

Cohen N. M., Lifshitz A., Jaschek R., Rinott E., Balicer R., Shlush L. I., Barbash G. I. & Tanay A. (2024), Nature Aging. 4, 1, p. 129-144

Longitudinal machine learning uncouples healthy aging factors from chronic disease risks

Cohen N. M., Lifshitz A., Jaschek R., Rinott E., Balicer R., Shlush L. I., Barbash G. I. & Tanay A. (2024), Nature Aging. 4, 1, p. 129-144