positions

Within the past decade, major advances have been made in the treatment of melanoma through the use of targeted therapy and immunotherapy, however responses are not universal and are not always durable. The project aims to further delineate the interactions of melanoma cells with the immune system to better understand molecular and immune mechanisms of therapeutic response and resistance. Our lab combines genomic tools, systems biology tools, advanced somatic cell knockout and knock-in techniques and various comprehensive mouse model approaches to study melanoma immune-genetics. Our studies link basic biology, computational biology and clinical studies. Trainees will learn sophisticated technologies such as whole exome sequencing, Riboseq, HLA-peptidomics,  somatic cell knockouts and expression and proteomic analyses. Candidates who wish to join the group may contact me at: Yardena.samuels@weizmann.ac.il

Triple negative breast cancer (TNBC) is a highly aggressive disease that affects young women and currently has no effective treatment. The goal of our studies is to identify new therapeutic strategies for this particular subtype of breast cancer. Synthetic lethality is a powerful approach to selectively eliminate vulnerable cancer cells, and thus can be exploited for cancer therapy. Many studies including our own indicate that synthetic lethality screens could be a promising approach to identify novel drug targets for TNBC. A postdoctoral position is available to establish a genome-wide synthetic lethal screen to identify potent combination therapies for TNBC subtypes.

Ferroptosis is a newly discovered cell death pathway driven by iron-dependent lipid peroxidation. We recently discovered new inducers of ferroptosis, and specific metabolic states that increase vulnerability to ferroptosis, and thus can be used for cancer therapy. We have multidisciplinary projects related to ferroptosis in TNBC, and we are currently looking for two talented and enthusiastic postdocs to join us.

We are looking for highly motivated post-doctoral fellow or research associate to an ERC funded project studying the "Biology of Ageing" at Weizmann Institute. The project is a collaboration of laboratories of Uri Alon, Tali Kimchi and Valery Krizhanovsky. It will combine cutting edge methods in molecular and cellular biology, behavioral neuroscience and system biology in mouse models. An expertise in behavioral neuroscience, molecular biology and mouse models is a plus.