Regulation of gene expression by endogenous small RNAs, called microRNAs (miRNA), affects many cellular processes in health and disease.

While hundreds of miRNA genes were discovered in recent years, the principles underlying the coordination of posttranscriptional regulation by miRNAs with signaling cascades and transcriptional networks are not well understood.

Additionally, characterizing the impact of specific miRNA genes on developmental and disease processes should provide important insight into human pathologies.

Research in the Hornstein group is aimed at uncovering the principles of miRNA function in development and disease, by utilizing mouse models, molecular and bioinformatic approaches.

Eran Hornstein, M.D./ Ph.D.
Department of Molecular Genetics

Tel: +972-8-934 6215