RNA emerges in recent years as a dominant mechanism for regulation of biological processes at all levels.
The aim of this course is to explore advanced topics in RNA-based regulation.
A strong focus is put on microRNA biochemistry, target selection and developmental impact, small RNA based regulation in prokaryotes including riboswitches, sRNA, and CRISPR.
The course will be substantiated by a set tutorials and a test, endowing 2.5 credit points.
Syllabus included
- Introduction to microRNA and the Classic Works of Ambros and Ruvkun.
- Posttranscriptional Processing of microRNA.
- microRNA:Target Pairing and RISC Function.
- miRNA Target Genomics.
- microRNA Function in Vertebrate Development.
- On miRNA in Plants.
- OncomiRs and Tumor Suppressor miRNAs.
- Small Bacterial RNAs -CRISPR.
- Additional Topics Discussed.
- Alternative Splicing.
- Nonsense Mediated RNA Decay.
- RNA Editing.
- RNA Secondary Structure.
- Bacterial ncRNAs and Riboswitches.
Extras