Publications

2019

Zelnik I. D., Rozman B., Rosenfeld-Gur E., Ben-Dor S. & Futerman A. H. (2019). A Stroll Down the CerS Lane.  . 49-63.  Abstract
Watson L., Keatinge M., Gegg M., Bai Q., Sandulescu M. C., Vardi A., Futerman A. H., Schapira A. H. V., Burton E. A. & Bandmann O. (2019). Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher's disease.  Neurobiology of Disease. 127:563-569.  Abstract
Megyeri M., Prasad R., Volpert G., Sliwa-Gonzalez A., Haribowo A. G., Aguilera-Romero A., Riezman H., Barral Y., Futerman A. H. & Schuldiner M. (2019). Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity.  Journal of Cell Science. 132:(12)  Abstract
Mitrofanova A., Mallela S. K., Ducasa G. M., Yoo T. H., Rosenfeld-Gur E., Zelnik I. D., Molina J., Santos J. V., Ge M., Sloan A., Kim J. J., Pedigo C., Bryn J., Volosenco I., Faul C., Zeidan Y. H., Hernandez C. G., Mendez A. J., Leibiger I., Burke G. W., Futerman A. H., Barisoni L., Ishimoto Y., Inagi R., Merscher S. & Fornoni A. (2019). SMPDL3b modulates insulin receptor signaling in diabetic kidney disease.  Nature Communications. 10.  Abstract
Zelnik I. D., Ventura A. E., Kim J. L., Silva L. C. & Futerman A. H. (2019). The role of ceramide in regulating endoplasmic reticulum function.  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  Abstract
Paget C., Deng S., Soulard D., Priestman D. A., Speca S., Von Gerichten J., Speak A. O., Saroha A., Pewzner-Jung Y., Futerman A. H., Mallevaey T., Faveeuw C., Gu X., Platt F. M., Sandhoff R. & Trottein F. (2019). TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells.  PLoS Biology. 17:(3)  Abstract
Kuo C., Kallemeijn W. W., Lelieveld L. T., Mirzaian M., Zoutendijk I., Vardi A., Futerman A. H., Meijer A. H., Spaink H. P., Overkleeft H. S., Aerts J. M. F. G. & Artola M. (2019). In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling.  The FEBS journal. 286:(3)584-600.  Abstract
Cho S. M., Vardi A., Platt N. & Futerman A. H. (2019). Absence of infiltrating peripheral myeloid cells in the brains of mouse models of lysosomal storage disorders.  Journal of Neurochemistry. 148:(5)625-638.  Abstract

2018

Fuller M. & Futerman A. H. (2018). The brain lipidome in neurodegenerative lysosomal storage disorders.  Biochemical and Biophysical Research Communications. 504:(3)623-628.  Abstract
Weinstock L. D., Furness A. M., Herron S. S., Smith S. S., Sankar S. B., Derosa S. G., Gao D., Mepyans M. E., Rosato A. S., Medina D. L., Vardi A., Ferreira N. S., Cho S. M., Futerman A. H., Slaugenhaupt S. A., Wood L. B. & Grishchuk Y. (2018). Fingolimod phosphate inhibits astrocyte inflammatory activity in mucolipidosis IV.  Human Molecular Genetics. 27:(15)1666-1679.  Abstract
Mizumura K., Justice M. J., Schweitzer K. S., Krishnan S., Bronova I., Berdyshev E. V., Hubbard W. C., Pewzner-Jung Y., Futerman A. H., Choi A. M. K. & Petrache I. (2018). Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure.  FASEB Journal. 32:(4)1880-1890.  Abstract
Eisenberg-Bord M., Mari M., Weill U., Rosenfeld-Gur E., Moldavski O., Castro I. G., Soni K. G., Harpaz N., Levine T. P., Futerman A. H., Reggiori F., Bankaitis V. A., Schuldiner M. & Bohnert M. (2018). Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation.  Journal of Cell Biology. 217:(1)269-282.  Abstract
Tidhar R., Zelnik I. D., Volpert G., Ben-Dor S., Kelly S., Merrill A. H. & Futerman A. H. (2018). Eleven residues determine the acyl chain specificity of ceramide synthases.  Journal of Biological Chemistry. 293:(25)9912-9921.  Abstract

2017

Kim Y., Volpert G., Shin K., Kim S., Shin S., Lee Y., Sung S. H., Lee Y., Ahn J., Pewzner-Jung Y., Park W., Futerman A. H. & Park J. (2017). Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability.  Journal of Cellular and Molecular Medicine. 21:(12)3565-3578.  Abstract
Saroha A., Pewzner-Jung Y., Ferreira N. S., Sharma P., Jouan Y., Kelly S. L., Feldmesser E., Merrill A. H., Trottein F., Paget C., Lang K. S. & Futerman A. H. (2017). Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis.  Frontiers in Immunology. 8.  Abstract
Cingolani F., Simbari F., Luis Abad A. J., Casasampere M., Fabrias G., Futerman A. H. & Casas J. (2017). Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase.  Journal of Lipid Research. 58:(8)1500-1513.  Abstract
Dasari S. K., Bialik S., Levin-Zaidman S., Levin-Salomon V., Merrill A. H. J., Futerman A. H. & Kimchi A. (2017). Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death.  Cell Death and Differentiation. 24:(7)1288-1302.  Abstract
Ferreira N. S., Engelsby H., Neess D., Kelly S. L., Volpert G., Merrill A. H., Futerman A. H. & Faergeman N. J. (2017). Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein.  Journal of Biological Chemistry. 292:(18)7588-7597.
Volpert G., Ben-Dor S., Tarcic O., Duan J., Saada A., Merrill A. H. J., Pewzner-Jung Y. & Futerman A. H. (2017). Oxidative stress elicited by modifying the ceramide acyl chain length reduces the rate of clathrin-mediated endocytosis.  Journal of Cell Science. 130:(8)1486-1493.  Abstract
Schonauer S., Koerschen H. G., Penno A., Rennhack A., Breiden B., Sandhoff K., Gutbrod K., Dormann P., Raju D. N., Haberkant P., Gerl M. J., Bruegger B., Zigdon H., Vardi A., Futerman A. H., Thiele C. & Wachten D. (2017). Identification of a feedback loop involving beta-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease.  Journal of Biological Chemistry. 292:(15)6177-6189.  Abstract
Hao L., Ben David D. O., Babb S. M., Futerman A. H., Cohen B. M. & Buttner E. A. (2017). Clozapine Modulates Glucosylceramide, Clears Aggregated Proteins, and Enhances ATG8/LC3 in Caenorhabditis elegans.  Neuropsychopharmacology. 42:(4)951-962.  Abstract
Zigdon H., Meshcheriakova A., Farfel-Becker T., Volpert G., Sabanay H. & Futerman A. H. (2017). Altered lysosome distribution is an early neuropathological event in neurological forms of Gaucher disease.  FEBS Letters. 591:(5)774-783.  Abstract
Lebesgue N., Megyeri M., Cristobal A., Scholten A., Chuartzman S. G., Voichek Y., Scheltema R. A., Mohammed S., Futerman A. H., Schuldiner M., Heck A. J. R. & Lemeer S. (2017). Combining Deep Sequencing, Proteomics, Phosphoproteomics, and Functional Screens To Discover Novel Regulators of Sphingolipid Homeostasis.  Journal of Proteome Research. 16:(2)571-582.  Abstract
Futerman A. H. & Platt F. M. (2017). The metabolism of glucocerebrosides - From 1965 to the present.  Molecular Genetics and Metabolism. 120:(1-2)22-26.  Abstract
Hubel E., Saroha A., Park W., Pewzner-Jung Y., Lavoie E. G., Futerman A. H., Bruck R., Fishman S., Dranoff J. A., Shibolet O. & Zvibel I. (2017). Sortilin Deficiency Reduces Ductular Reaction, Hepatocyte Apoptosis, and Liver Fibrosis in Cholestatic-Induced Liver Injury.  American Journal of Pathology. 187:(1)122-133.
Varela A., Ventura A., Carreira A., Fedorov A., Futerman A. H., Prieto M. & Silva L. (2017). Pathological levels of glucosylceramide change the biophysical properties of artificial and cell membranes.  Physical Chemistry Chemical Physics. 19:(1)340-346.  Abstract

2016

Megyeri M., Riezman H., Schuldiner M. & Futerman A. H. (2016). Making Sense of the Yeast Sphingolipid Pathway.  Journal of Molecular Biology. 428:(24)4765-4775.  Abstract
Futerman A. H. & Hardy J. (2016). Finding common ground PERSPECTIVE Finding common ground.  Nature. 537:(7621)S160-S161.
Sato R., Tobioka K. & Futerman A. H. (2016). LHC future prospects of the 750 GeV resonance.  Physics Letters B. 760:590-593.  Abstract
Macritchie N., Volpert G., Al Washih W. M., Watson D. G., Futerman A. H., Kennedy S., Pyne S. & Pyne N. J. (2016). Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.  Cellular Signalling. 28:(8)946-955.  Abstract
Klein A. D., Ferreira N., Ben-Dor S., Duan J., Hardy J., Cox T. M., Merrill A. H. J. & Futerman A. H. (2016). Identification of Modifier Genes in a Mouse Model of Gaucher Disease.  Cell Reports. 16:(10)2546-53.  Abstract
Vardi A., Vitner E., Yaacobi C., Eilam R., Klein A. D., Meshcheriakova A., Zigdon H. & Futerman A. H. (2016). Delineating pathological pathways in a chemically induced mouse model of Gaucher disease.  The Journal of Pathology. 238:(4)
Pewzner-Jung Y. & Futerman A. H. (2016). KCa 3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stress.  Aging Cell. 15:(5)801-810.
Vitner E. B., Farfel-Becker T., Ferreira N. S., Leshkowitz D., Sharma P., Lang K. S. & Futerman A. H. (2016). Induction of the type I interferon response in neurological forms of Gaucher disease.  Journal of Neuroinflammation. 13.  Abstract
Varela A. R. P., Couto A. S., Fedorov A., Futerman A. H., Prieto M. & Silva L. C. (2016). Glucosylceramide Reorganizes Cholesterol-Containing Domains in a Fluid Phospholipid Membrane.  Biophysical Journal. 110:(3)612-622.  Abstract

2015

Choi S., Kim J. A., Kim T. H., Li H., Shin K., Lee Y., Oh S., Pewzner-Jung Y., Futerman A. H. & Suh S. H. (2015). Altering sphingolipid composition with aging induces contractile dysfunction of gastric smooth muscle via K(Ca)1.1 upregulation.  Aging Cell. 14:(6)982-994.  Abstract
Ali M., Saroha A., Pewzner-Jung Y. & Futerman A. H. (2015). LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNF alpha-converting enzyme.  FEBS Letters. 589:(17)2213-2217.  Abstract
Park W., Brenner O., Kogot-Levin A., Saada A., Merrill A., Pewzner-Jung Y. & Futerman A. H. (2015). Development of pheochromocytoma in ceramide synthase 2 null mice.  Endocrine-Related Cancer. 22:(4)623-632.  Abstract
Vitner E. B., Futerman A. H. & Platt N. (2015). Innate immune responses in the brain of sphingolipid lysosomal storage diseases.  Biological Chemistry. 396:(7-Jun)659-667.  Abstract
Barthelmes J., De Bazo B. A. M., Pewzner-Jung Y., Schmitz K., Mayer C. A., Foerch C., Eberle M., Tafferner N., Ferreiros N., Henke M., Geisslinger G., Futerman A. H., Grosch S. & Schiffmann S. (2015). Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils.  Brain Behavior And Immunity. 46:280-292.  Abstract
Futerman A. H. (2015). Preface to the Special Issue on brain lipids.  Biochimica Et Biophysica Acta. 1851:(8)997-8.
Zigdon H., Savidor A., Levin Y., Meshcheriakova A., Schiffmann R. & Futerman A. H. (2015). Identification of a Biomarker in Cerebrospinal Fluid for Neuronopathic Forms of Gaucher Disease.  PLoS One. 10:(3)  Abstract
Vitner E. B., Vardi A., Cox T. M. & Futerman A. H. (2015). Emerging therapeutic targets for Gaucher disease.  Expert Opinion on Therapeutic Targets. 19:(3)321-334.  Abstract
Tidhar R., Sims K., Rosenfeld-Gur E., Shaw W. & Futerman A. H. (2015). A rapid ceramide synthase activity using NBD-sphinganine and solid phase extraction.  Journal of Lipid Research. 56:(1)193-199.  Abstract
Rabinowich L., Fishman S., Hubel E., Thurm T., Park W., Pewzner-Jung Y., Saroha A., Erez N., Halpern Z., Futerman A. H. & Zvibel I. (2015). Sortilin deficiency improves the metabolic phenotype and reduces hepatic steatosis of mice subjected to diet-induced obesity.  Journal of Hepatology. 62:(1)175-181.  Abstract

2014

Park W., Park J., Merrill A. H. J., Storch J., Pewzner-Jung Y. & Futerman A. H. (2014). Hepatic fatty acid uptake is regulated by the sphingolipid acyl chain length.  Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids. 1841:(12)1754-1766.  Abstract
Raichur S., Wang S. T., Chan P. W., Li Y., Ching J., Chaurasia B., Dogra S., Oehman M. K., Takeda K., Sugii S., Pewzner-Jung Y., Futerman A. H. & Summers S. A. (2014). CerS2 Haploinsufficiency Inhibits beta-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance.  Cell Metabolism. 20:(4)687-695.  Abstract
Pewzner-Jung Y., Tabazavareh S. T., Grassme H., Becker K. A., Japtok L., Steinmann J., Joseph T., Lang S., Tuemmler B., Schuchman E. H., Lentsch A. B., Kleuser B., Edwards M. J., Futerman A. H. & Gulbins E. (2014). Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa.  EMBO Molecular Medicine. 6:(9)1205-1214.  Abstract
Zigdon H., Meshcheriakova A. & Futerman A. H. (2014). From sheep to mice to cells: Tools for the study of the sphingolipidoses.  Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids. 1841:(8)1189-1199.  Abstract
Reuven E., Ali M., Rotem E., Schwarzter R., Gramatica A., Futerman A. H. & Shai Y. (2014). The HIV-1 Envelope Transmembrane Domain Binds TLR2 through a Distinct Dimerization Motif and Inhibits TLR2-Mediated Responses.  PLoS Pathogens. 10:(8)  Abstract
Elbaz-Alon Y., Rosenfeld-Gur E., Shinder V., Futerman A. H., Geiger T. & Schuldiner M. (2014). A Dynamic Interface between Vacuoles and Mitochondria in Yeast.  Developmental Cell. 30:(1)95-102.  Abstract
Park J., Park W. & Futerman A. H. (2014). Ceramide synthases as potential targets for therapeutic intervention in human diseases.  Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids. 1841:(5)671-681.  Abstract
Varela A. R. P., Goncalves Da Silva D. S. A. M. P. S., Fedorov A., Futerman A. H., Prieto M. & Silva L. C. (2014). Influence of Intracellular Membrane pH on Sphingolipid Organization and Membrane Biophysical Properties.  Langmuir. 30:(14)4094-4104.  Abstract
Jensen S. A., Calvert A. E., Volpert G., Kouri F. M., Hurley L. A., Luciano J. P., Wu Y., Chalastanis A., Futerman A. H. & Stegh A. H. (2014). Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.  Proceedings of the National Academy of Sciences of the United States of America. 111:(15)5682-5687.  Abstract
Vitner E. B., Salomon R., Farfel-Becker T., Meshcheriakova A., Ali M., Klein A. D., Platt F. M., Cox T. M. & Futerman A. H. (2014). RIPK3 as a potential therapeutic target for Gaucher's disease.  Nature Medicine. 20:(2)204-208.  Abstract
Farfel-Becker T., Vitner E. B., Kelly S. L., Bame J. R., Duan J., Shinder V., Merrill A. H. J., Dobrenis K. & Futerman A. H. (2014). Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration.  Human Molecular Genetics. 23:(4)843-854.  Abstract
Pinto S. N., Laviad E. L., Stiban J., Kelly S. L., Merrill A. H. J., Prieto M., Futerman A. H. & Silva L. C. (2014). Changes in membrane biophysical properties induced by sphingomyelinase depend on the sphingolipid N-acyl chain.  Journal of Lipid Research. 55:(1)53-61.  Abstract
Ferreira N. S., Goldschmidt-Arzi M., Sabanay H., Storch J., Levade T., Ribeiro M. G., Addadi L. & Futerman A. H. (2014). Accumulation of Ordered Ceramide-Cholesterol Domains in Farber Disease Fibroblasts.  Jimd Reports, Vol 12. 71-77.  Abstract

2013

Cohen Y., Megyeri M., Chen O. C. W., Condomitti G., Riezman I., Loizides-Mangold U., Abdul-Sada A., Rimon N., Riezman H., Platt F. M., Futerman A. H. & Schuldiner M. (2013). The Yeast P5 Type ATPase, Spf1, Regulates Manganese Transport into the Endoplasmic Reticulum.  PLoS One. 8:(12)  Abstract
Tidhar R. & Futerman A. H. (2013). The complexity of sphingolipid biosynthesis in the endoplasmic reticulum.  Biochimica Et Biophysica Acta-Molecular Cell Research. 1833:(11)2511-2518.  Abstract
Ali M., Fritsch J., Zigdon H., Pewzner-Jung Y., Schuetze S. & Futerman A. H. (2013). Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization.  Cell Death & Disease. 4.  Abstract
Park W., Park J., Erez Roman R. R., Kogot-Levin A., Bame J. R., Tirosh B., Saada A., Merrill A. H. J., Pewzner-Jung Y. & Futerman A. H. (2013). Protection of a Ceramide Synthase 2 Null Mouse from Drug-induced Liver Injury ROLE OF GAP JUNCTION DYSFUNCTION AND CONNEXIN 32 MISLOCALIZATION.  Journal of Biological Chemistry. 288:(43)30904-30916.  Abstract
Eckl K., Tidhar R., Thiele H., Oji V., Hausser I., Brodesser S., Preil M., Oenal-Akan A., Stock F., Mueller D., Becker K., Casper R., Nuernberg G., Altmueller J., Nuernberg P., Traupe H., Futerman A. H. & Hennies H. C. (2013). Impaired Epidermal Ceramide Synthesis Causes Autosomal Recessive Congenital Ichthyosis and Reveals the Importance of Ceramide Acyl Chain Length.  Journal of Investigative Dermatology. 133:(9)2202-2211.  Abstract
Pinto S. N., Fernandes F., Fedorov A., Futerman A. H., Silva L. C. & Prieto M. (2013). A combined fluorescence spectroscopy, confocal and 2-photon microscopy approach to re-evaluate the properties of sphingolipid domains.  Biochimica Et Biophysica Acta-Biomembranes. 1828:(9)2099-2110.  Abstract
Halasiddappa L. M., Koefeler H., Futerman A. H. & Hermetter A. (2013). Oxidized Phospholipids Induce Ceramide Accumulation in RAW 264.7 Macrophages: Role of Ceramide Synthases.  PLoS One. 8:(7)  Abstract
Russo S. B., Tidhar R., Futerman A. H. & Cowart L. A. (2013). Myristate-derived d16: Sphingolipids Constitute a Cardiac Sphingolipid Pool with Distinct Synthetic Routes and Functional Properties.  Journal of Biological Chemistry. 288:(19)13397-13409.  Abstract
Petrache I., Kamocki K., Poirier C., Pewzner-Jung Y., Laviad E. L., Schweitzer K. S., Van Demark D. M., Justice M. J., Hubbard W. C. & Futerman A. H. (2013). Ceramide Synthases Expression and Role of Ceramide Synthase-2 in the Lung: Insight from Human Lung Cells and Mouse Models.  PLoS One. 8:(5)  Abstract
Harrer H., Laviad E. L., Humpf H. U. & Futerman A. H. (2013). Identification of N-acyl-fumonisin B1 as new cytotoxic metabolites of fumonisin mycotoxins.  Molecular Nutrition & Food Research. 57:(3)516-522.  Abstract
Varela A. R. P., Goncalves Da Silva D. S. A. M. P. S., Fedorov A., Futerman A. H., Prieto M. & Silva L. C. (2013). Effect of glucosylceramide on the biophysical properties of fluid membranes.  Biochimica Et Biophysica Acta-Biomembranes. 1828:(3)1122-1130.  Abstract
Park J., Park W., Kuperman Y., Boura-Halfon S., Pewzner-Jung Y. & Futerman A. H. (2013). Ablation of Very Long Acyl Chain Sphingolipids Causes Hepatic Insulin Resistance in Mice Due to Altered Detergent-Resistant Membranes.  Hepatology. 57:(2)525-532.  Abstract
Zigdon H., Kogot-Levin A., Park J., Goldschmidt R., Kelly S., Merrill A. H. J., Scherz A., Pewzner-Jung Y., Saada A. & Futerman A. H. (2013). Ablation of Ceramide Synthase 2 Causes Chronic Oxidative Stress Due to Disruption of the Mitochondrial Respiratory Chain.  Journal of Biological Chemistry. 288:(7)4947-4956.  Abstract

2012

Nevet M. J., Vekslin S., Dizhoor A. M., Olshevskaya E. V., Tidhar R., Futerman A. H. & Ben-Yosef T. (2012). Ceramide Kinase-Like (CERKL) Interacts with Neuronal Calcium Sensor Proteins in the Retina in a Cation-Dependent Manner.  Investigative Ophthalmology & Visual Science. 53:(8)4565-4574.  Abstract
Hullin-Matsuda F., Tomishige N., Sakai S., Ishitsuka R., Ishii K., Makino A., Greimel P., Abe M., Laviad E. L., Lagarde M., Vidal H., Saito T., Osada H., Hanada K., Futerman A. H. & Kobayashi T. (2012). Limonoid Compounds Inhibit Sphingomyelin Biosynthesis by Preventing CERT Protein-dependent Extraction of Ceramides from the Endoplasmic Reticulum.  Journal of Biological Chemistry. 287:(29)24397-24411.  Abstract
Laviad E. L., Kelly S., Merrill A. H. J. & Futerman A. H. (2012). Modulation of Ceramide Synthase Activity via Dimerization.  Journal of Biological Chemistry. 287:(25)21025-21033.  Abstract
Vitner E. B., Farfel-Becker T., Eilam R., Biton I. & Futerman A. H. (2012). Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease.  Brain. 135:1724-1735.  Abstract
Singh A., Wang H., Silva L. C., Na C., Prieto M., Futerman A. H., Luberto C. & Del Poeta P. M. (2012). Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans.  Cellular Microbiology. 14:(4)500-516.  Abstract
Silva L. C., Ben David D. O., Pewzner-Jung Y., Laviad E. L., Stiban J., Bandyopadhyay S., Merrill A. H. J., Prieto M. & Futerman A. H. (2012). Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes.  Journal of Lipid Research. 53:(3)430-436.  Abstract
Tidhar R., Ben-Dor S., Wang E., Kelly S., Merrill A. H. J. & Futerman A. H. (2012). Acyl Chain Specificity of Ceramide Synthases Is Determined within a Region of 150 Residues in the Tram-Lag-CLN8 (TLC) Domain.  Journal of Biological Chemistry. 287:(5)3197-3206.  Abstract

2011

Yurlova L., Kahya N., Aggarwal S., Kaiser H., Chiantia S., Bakhti M., Pewzner-Jung Y., Ben David D. O., Futerman A. H., Bruegger B. & Simons M. (2011). Self-Segregation of Myelin Membrane Lipids in Model Membranes.  Biophysical Journal. 101:(11)2713-2720.  Abstract
Pinto S. N., Silva L. C., Futerman A. H. & Prieto M. (2011). Effect of ceramide structure on membrane biophysical properties: The role of acyl chain length and unsaturation.  Biochimica Et Biophysica Acta-Biomembranes. 1808:(11)2753-2760.  Abstract
Farfel-Becker T., Vitner E. B. & Futerman A. H. (2011). Animal models for Gaucher disease research.  Disease Models & Mechanisms. 4:(6)746-752.  Abstract
Offman M. N., Krol M., Rost B., Silman I., Sussman J. & Futerman A. H. (2011). Comparison of a molecular dynamics model with the X-ray structure of the N370S acid--glucosidase mutant that causes Gaucher disease.  Protein Engineering Design & Selection. 24:(10)773-775.  Abstract
Shachar T., Lo Bianco B. C., Recchia A., Wiessner C., Raas-Rothschild A. & Futerman A. H. (2011). Lysosomal Storage Disorders and Parkinson's Disease: Gaucher Disease and Beyond.  Movement Disorders. 26:(9)1593-1604.  Abstract
Ben David D. O., Pewzner-Jung Y., Brenner O., Laviad E. L., Kogot-Levin A., Weissberg I., Biton I. E., Pienik R., Wang E., Kelly S., Alroy J., Raas-Rothschild A., Friedman A., Bruegger B., Merrill A. H. J. & Futerman A. H. (2011). Encephalopathy Caused by Ablation of Very Long Acyl Chain Ceramide Synthesis May Be Largely Due to Reduced Galactosylceramide Levels.  Journal of Biological Chemistry. 286:(34)30022-30033.  Abstract
Goldschmidt-Arzi M., Shimoni E., Sabanay H., Futerman A. H. & Addadi L. (2011). Intracellular localization of organized lipid domains of C16-ceramide/cholesterol.  Journal of Structural Biology. 175:(1)21-30.  Abstract
Farfel-Becker T., Vitner E. B., Pressey S. N. R., Eilam R., Cooper J. D. & Futerman A. H. (2011). Spatial and temporal correlation between neuron loss and neuroinflammation in a mouse model of neuronopathic Gaucher disease.  Human Molecular Genetics. 20:(7)1375-1386.  Abstract
Brumshtein B., Aguilar-Moncayo M., Benito J. M., Garcia Fernandez F. J. M., Silman I., Shaaltiel Y., Aviezer D., Sussman J., Futerman A. H. & Ortiz Mellet M. C. (2011). Cyclodextrin-mediated crystallization of acid beta-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues.  Organic & Biomolecular Chemistry. 9:(11)4160-4167.  Abstract

2010

Ben David D. O. & Futerman A. H. (2010). The Role of the Ceramide Acyl Chain Length in Neurodegeneration: Involvement of Ceramide Synthases.  NeuroMolecular Medicine. 12:(4)341-350.  Abstract
Offman M. N., Krol M., Silman I., Sussman J. & Futerman A. H. (2010). Molecular Basis of Reduced Glucosylceramidase Activity in the Most Common Gaucher Disease Mutant, N370S.  Journal of Biological Chemistry. 285:(53)42105-42114.  Abstract
Vitner E. B., Dekel H., Zigdon H., Shachar T., Farfel-Becker T., Eilam R., Karlsson S. & Futerman A. H. (2010). Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidoses.  Human Molecular Genetics. 19:(18)3583-3590.  Abstract
Futerman A. H. (2010). Mammalian ceramide synthases.  Chemistry and Physics of Lipids. 163:S9-S9.  Abstract
Vitner E. B., Platt F. M. & Futerman A. H. (2010). Common and Uncommon Pathogenic Cascades in Lysosomal Storage Diseases.  Journal of Biological Chemistry. 285:(27)20423-20427.  Abstract
Futerman A. H. & Schuldiner M. (2010). The plasma membrane code.  Nature Chemical Biology. 6:(7)487-488.
Levy M. & Futerman A. H. (2010). Mammalian Ceramide Synthases.  IUBMB Life. 62:(5)347-356.  Abstract
Pewzner-Jung Y., Brenner O., Braun S., Laviad E. L., Ben-Dor S., Feldmesser E., Horn-Saban S., Amann Zalcenstein Z. D., Raanan C., Berkutzki T., Erez Roman R. R., Ben David D. O., Levy M., Holzman D., Park H., Nyska A., Merrill A. H. J. & Futerman A. H. (2010). A Critical Role for Ceramide Synthase 2 in Liver Homeostasis II. INSIGHTS INTO MOLECULAR CHANGES LEADING TO HEPATOPATHY.  Journal of Biological Chemistry. 285:(14)10911-10923.  Abstract
Pewzner-Jung Y., Park H., Laviad E. L., Silva L. C., Lahiri S., Stiban J., Erez Roman R. R., Bruegger B., Sachsenheimer T., Wieland F., Prieto M., Merrill A. H. J. & Futerman A. H. (2010). A Critical Role for Ceramide Synthase 2 in Liver Homeostasis I. ALTERATIONS IN LIPID METABOLIC PATHWAYS.  Journal of Biological Chemistry. 285:(14)10902-10910.  Abstract
Farfel-Becker T. & Futerman A. H. (2010). Cellular pathogenesis in sphingolipid storage disorders: the quest for new therapeutic approaches.  Clinical Lipidology. 5:(2)255-265.  Abstract
Erez Roman R. R., Pienik R. & Futerman A. H. (2010). Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.  Biochemical and Biophysical Research Communications. 391:(1)219-223.  Abstract
Brumshtein B., Salinas P., Peterson B., Chan V., Silman I., Sussman J., Savickas P. J., Robinson G. S. & Futerman A. H. (2010). Characterization of gene-activated human acid-beta-glucosidase: Crystal structure, glycan composition, and internalization into macrophages.  Glycobiology. 20:(1)24-32.  Abstract
Sridevi P., Alexander H., Laviad E. L., Min J., Mesika A., Hannink M., Futerman A. H. & Alexander S. (2010). Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing.  Experimental Cell Research. 316:(1)78-91.  Abstract
Stiban J., Tidhar R. & Futerman A. H. (2010). Ceramide Synthases: Roles in Cell Physiology and Signaling.  Sphingolipids As Signaling And Regulatory Molecules. 60-71.  Abstract

2009

Futerman A. H. (2009). The complexities of sphingolipid synthesis.  Chemistry and Physics of Lipids. 160:S10-S10.  Abstract
Kacher Y. & Futerman A. H. (2009). Impaired IL-10 transcription and release in animal models of Gaucher disease macrophages.  Blood Cells Molecules And Diseases. 43:(1)134-137.  Abstract
Sridevi P., Alexander H., Laviad E. L., Pewzner-Jung Y., Hannink M., Futerman A. H. & Alexander S. (2009). Ceramide synthase 1 is regulated by proteasomal mediated turnover.  Biochimica Et Biophysica Acta-Molecular Cell Research. 1793:(7)1218-1227.  Abstract
Lahiri S., Park H., Laviad E. L., Lu X., Bittman R. & Futerman A. H. (2009). Ceramide Synthesis Is Modulated by the Sphingosine Analog FTY720 via a Mixture of Uncompetitive and Noncompetitive Inhibition in an Acyl-CoA Chain Length-dependent Manner.  Journal of Biological Chemistry. 284:(24)16090-16098.  Abstract
Brumshtein B., Aguilar-Moncayo M., Isabel Garcia-Moreno G. M., Ortiz Mellet M. C., Garcia Fernandez F. J. M., Silman I., Shaaltiel Y., Aviezer D., Sussman J. & Futerman A. H. (2009). 6-Amino-6-deoxy-5,6-di-N-(N '-octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid beta-Glucosidase.  ChemBioChem. 10:(9)1480-1485.
Goldfinger M., Laviad E. L., Hadar R., Shmuel M., Dagan A., Park H., Merrill A. H. J., Ringel I., Futerman A. H. & Tirosh B. (2009). De Novo Ceramide Synthesis Is Required for N-Linked Glycosylation in Plasma Cells.  Journal of Immunology. 182:(11)7038-7047.  Abstract
Silva L. C., Futerman A. H. & Prieto M. (2009). Lipid Raft Composition Modulates Sphingomyelinase Activity and Ceramide-Induced Membrane Physical Alterations.  Biophysical Journal. 96:(8)3210-3222.  Abstract
Farfel-Becker T., Vitner E., Dekel H., Leshem N., Enquist I. B., Karlsson S. & Futerman A. H. (2009). No evidence for activation of the unfolded protein response in neuronopathic models of Gaucher disease.  Human Molecular Genetics. 18:(8)1482-1488.  Abstract

2008

Kacher Y., Brumshtein B., Boldin-Adamsky S., Toker L., Shainskaya A., Silman I., Sussman J. & Futerman A. H. (2008). Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy.  Biological Chemistry. 389:(11)1361-1369.  Abstract
Brumshtein B., Greenblatt H. M., Futerman A. H., Silman I. & Sussman J. (2008). Control of the rate of evaporation in protein crystallization by the 'microbatch under oil' method.  Journal of Applied Crystallography. 41:969-971.  Abstract
Laviad E. L., Albee L., Pankova-Kholmyansky I., Epstein S., Park H., Merrill A. H. J. & Futerman A. H. (2008). Characterization of ceramide synthase 2 - Tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate.  Journal of Biological Chemistry. 283:(9)5677-5684.  Abstract
Ginzburg L., Li S., Li Y. & Futerman A. H. (2008). An exposed carboxyl group on sialic acid is essential for gangliosides to inhibit calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase: relevance to gangliosidoses.  Journal of Neurochemistry. 104:(1)140-146.  Abstract
Stiban J., Silva L. C. & Futerman A. H. (2008). Ceramide-containing membranes: the interface between biophysics and biology.  Trends in Glycoscience and Glycotechnology. 20:(116)297-313.  Abstract

2007

Futerman A. H. (2007). Defective neuronal function in LSDs.  Molecular Genetics and Metabolism. 92:(4)S11-S11.  Abstract
Scheffer L., Futerman A. H. & Addadi L. (2007). Antibody labeling of cholesterol/ceramide ordered domains in cell membranes.  ChemBioChem. 8:(18)2286-2294.  Abstract
Lahiri S., Lee H., Mesicek J., Fuks Z., Haimovitz-Friedman A., Kolesnick R. N. & Futerman A. H. (2007). Kinetic characterization of mammalian ceramide synthases: Determination of K-m values towards sphinganine.  FEBS Letters. 581:(27)5289-5294.  Abstract
Futerman A. H. (2007). An appreciation of Dr Steven Pfeiffer, 1940-2007.  Journal of Neurochemistry. 103:1-1.
Brumshtein B., Greenblatt H. M., Butters T. D., Shaaltiel Y., Aviezer D., Silman I., Futerman A. H. & Sussman J. (2007). Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase - Insights into the mechanism of chemical chaperone action in Gaucher disease.  Journal of Biological Chemistry. 282:(39)29052-29058.  Abstract
Futerman A. H. (2007). Cell biology - Taxi service for lipids.  Nature. 449:(7158)35-+.
Mesika A., Ben-Dor S., Laviad E. L. & Futerman A. H. (2007). New functional motif in Hox domain-containing ceramide Synthases - Identification of a novel region flanking the Hox and TLC domains essential for activity.  Journal of Biological Chemistry. 282:(37)27366-27373.  Abstract
Shaaltiel Y., Bartfeld D., Hashmueli S., Baum G., Brill-Almon E., Galili G., Dym O., Boldin-Adamsky S. A., Silman I., Sussman J., Futerman A. H. & Aviezer D. (2007). Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system.  Plant Biotechnology Journal. 5:(5)579-590.  Abstract
Lahiri S. & Futerman A. H. (2007). The metabolism and function of sphingolipids and glycosphingolipids.  Cellular and Molecular Life Sciences. 64:(17)2270-2284.  Abstract
Min J., Mesika A., Sivaguru M., Van Veldhoven V. P. P., Alexander H., Futerman A. H. & Alexanderl S. (2007). (Dihydro)ceramide synthase 1-regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1.  Molecular Cancer Research. 5:(8)801-812.  Abstract
Kacher Y., Golan A., Pewzner-Jung Y. & Futerman A. H. (2007). Changes in macrophage morphology in a Gaucher disease model are dependent on CTP: phosphocholine cytidylyltransferase alpha.  Blood Cells Molecules And Diseases. 39:(1)124-129.  Abstract

2006

Futerman A. H. (2006). Intracellular trafficking of sphingolipids: Relationship to biosynthesis.  Biochimica Et Biophysica Acta-Biomembranes. 1758:(12)1885-1892.  Abstract
Brumshtein B., Wormald M. R., Silman I., Futerman A. H. & Sussman J. (2006). Structural Comparison Of Differently Glycosylated Forms Of Acid-Beta-Glucosidase, The Defective Enzyme In Gaucher Disease.  Acta Crystallographica Section D-Biological Crystallography. 62:1458-1465.  Abstract
Kacher Y. & Futerman A. H. (2006). Genetic diseases of sphingolipid metabolism: Pathological mechanisms and therapeutic options.  FEBS Letters. 580:(23)5510-5517.  Abstract
Pewzner-Jung Y., Ben-Dor S. & Futerman A. H. (2006). When do lasses (longevity assurance genes) become CerS (ceramide synthases)? Insights into the regulation of ceramide synthesis.  Journal of Biological Chemistry. 281:(35)25001-25005.
Hillaert U., Boldin-Adamsky S., Rozenski J., Busson R., Futerman A. H. & Van Calenbergh C. S. (2006). Synthesis and biological evaluation of novel PDMP analogues.  Bioorganic & Medicinal Chemistry. 14:(15)5273-5284.  Abstract
Arfi A., Zisling R., Richard E., Batista L., Poenaru L., Futerman A. H. & Caillaud C. (2006). Reversion of the biochemical defects in murine embryonic Sandhoff neurons using a bicistronic lentiviral vector encoding hexosaminidase alpha and beta.  Journal of Neurochemistry. 96:(6)1572-1579.  Abstract

2005

Ginzburg L. & Futerman A. H. (2005). Defective calcium homeostasis in the cerebellum in a mouse model of Niemann-Pick A disease.  Journal of Neurochemistry. 95:(6)1619-1628.  Abstract
Futerman A. H. (2005). Lysosomal storage diseases: pathological mechanisms and therapeutic options.  M S-Medecine Sciences. 21:16-19.  Abstract
Lahiri S. & Futerman A. H. (2005). LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.  Journal of Biological Chemistry. 280:(40)33735-33738.  Abstract
Premkumar L., Sawkar A., Boldin-Adamsky S., Toker L., Silman I., Kelly J., Futerman A. H. & Sussman J. (2005). X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide - Implications for Gaucher disease.  Journal of Biological Chemistry. 280:(25)23815-23819.  Abstract
Futerman A. H. & Riezman H. (2005). The ins and outs of sphingolipid synthesis.  Trends in Cell Biology. 15:(6)312-318.  Abstract
Jmoudiak M. & Futerman A. H. (2005). Gaucher disease: pathological mechanisms and modern management.  British Journal of Haematology. 129:(2)178-188.  Abstract
Cohen T., Auerbach W., Ravid L., Bodennec J., Fein A., Futerman A. H., Joyner A. & Horowitz M. (2005). The exon 8-containing prosaposin gene splice variant is dispensable for mouse development, lysosomal function, and secretion.  Molecular and Cellular Biology. 25:(6)2431-2440.  Abstract
Pelled D., Trajkovic-Bodennec S., Lloyd-Evans E., Sidransky E., Schiffmann R. & Futerman A. H. (2005). Enhanced calcium release in the acute neuronopathic form of Gaucher disease.  Neurobiology of Disease. 18:(1)83-88.  Abstract

2004

Futerman A. H. & Hannun Y. (2004). The complex life of simple sphingolipids.  EMBO Reports. 5:(8)777-782.  Abstract
Ginzburg L., Kacher Y. & Futerman A. H. (2004). The pathogenesis of glycosphingolipid storage disorders.  Seminars in Cell & Developmental Biology. 15:(4)417-431.  Abstract
Futerman A. H. & Van Meer M. G. (2004). The cell biology of lysosomal storage disorders.  Nature Reviews Molecular Cell Biology. 5:(7)554-565.  Abstract
Trajkovic-Bodennec S., Bodennec J. & Futerman A. H. (2004). Phosphatidylcholine metabolism is altered in a monocyte-derived macrophage model of Gaucher disease but not in lymphocytes.  Blood Cells Molecules And Diseases. 33:(1)77-82.  Abstract
Buccoliero R., Bodennec J., Van Echten-Deckert E. G., Sandhoff K. & Futerman A. H. (2004). Phospholipid synthesis is decreased in neuronal tissue in a mouse model of Sandhoff disease.  Journal of Neurochemistry. 90:(1)80-88.  Abstract
Futerman A. H., Sussman J., Horowitz M., Silman I. & Zimran A. (2004). New directions in the treatment of Gaucher disease.  Trends in Pharmacological Sciences. 25:(3)147-151.  Abstract
Buccoliero R., Ginzburg L. & Futerman A. H. (2004). Elevation of lung surfactant phosphatidylcholine in mouse models of Sandhoff and of Niemann-Pick A disease.  Journal of Inherited Metabolic Disease. 27:(5)641-648.  Abstract
Raas-Rothschild A., Pankova-Kholmyansky I., Kacher Y. & Futerman A. H. (2004). Glycosphingolipidoses: Beyond the enzymatic defect.  Glycoconjugate Journal. 21:(6)295-304.  Abstract

2003

Lloyd-Evans E., Pelled D., Riebeling C. & Futerman A. H. (2003). Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms.  Biochemical Journal. 375:561-565.  Abstract
Riebeling C., Allegood J., Wang E., Merrill A. & Futerman A. H. (2003). Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.  Journal of Biological Chemistry. 278:(44)43452-43459.  Abstract
Pelled D., Lloyd-Evans E., Riebeling C., Jeyakumar M., Platt F. & Futerman A. H. (2003). Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin.  Journal of Biological Chemistry. 278:(32)29496-29501.  Abstract
Pelled D., Riebeling C., Van Echten-Deckert E. G., Sandhoff K. & Futerman A. H. (2003). Reduced rates of axonal and dendritic growth in embryonic hippocampal neurones cultured from a mouse model of Sandhoff disease.  Neuropathology and Applied Neurobiology. 29:(4)341-349.  Abstract
Bodennec J., Trajkovic-Bodennec S. & Futerman A. H. (2003). Simultaneous quantification of lyso-neutral glycosphingolipids and neutral glycosphingolipids by N-acetylation with [H-3]acetic anhydride.  Journal of Lipid Research. 44:(7)1413-1419.  Abstract
Dvir H., Harel M., Mccarthy A., Toker L., Silman I., Futerman A. H. & Sussman J. (2003). X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease.  EMBO Reports. 4:(7)704-709.  Abstract
Lloyd-Evans E., Pelled D., Riebeling C., Bodennec J., De-Morgan A., Waller H., Schiffmann R. & Futerman A. H. (2003). Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms.  Journal of Biological Chemistry. 278:(26)23594-23599.  Abstract
Buccoliero R. & Futerman A. H. (2003). The roles of ceramide and complex sphingolipids in neuronal cell function.  Pharmacological Research. 47:(5)409-419.  Abstract
Bodennec J., Pelled D. & Futerman A. H. (2003). Aminopropyl solid phase extraction and 2 D TLC of neutral glycosphingolipids and neutral lysoglycosphingolipids.  Journal of Lipid Research. 44:(1)218-226.  Abstract

2002

Watanabe R., Funato K., Venkataramam K., Futerman A. H. & Riezman H. (2002). Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.  Journal of Biological Chemistry. 277:(51)49538-49544.  Abstract
Bodennec J., Pelled D., Riebeling C., Trajkovic S. & Futerman A. H. (2002). Phosphatidylcholine synthesis is elevated in neuronal models of Gaucher disease due to direct activation of CTP: phosphocholine cytidylyltransferase by glucosylceramide.  FASEB Journal. 16:(13)1814-+.  Abstract
Venkataraman K. & Futerman A. H. (2002). Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis?.  FEBS Letters. 528:(3-Jan)3-4.  Abstract
Venkataraman K., Riebeling C., Bodennec J., Riezman H., Allegood J., Sullard M., Merrill A. & Futerman A. H. (2002). Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B-1-independent manner in mammalian cells.  Journal of Biological Chemistry. 277:(38)35642-35649.  Abstract
Buccoliero R., Bodennec J. & Futerman A. H. (2002). The role of sphingolipids in neuronal development: Lessons from models of sphingolipid storage diseases.  Neurochemical Research. 27:(8-Jul)565-574.  Abstract
Brann A., Tcherpakov M., Williams I., Futerman A. H. & Fainzilber M. (2002). Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase.  Journal of Biological Chemistry. 277:(12)9812-9818.  Abstract
De Jonghe J. S., Lamote I., Venkataraman K., Boldin S., Hillaert U., Rozenski J., Hendrix C., Busson R., De Keukeleire K. D., Van Calenbergh C. S., Futerman A. H. & Herdewijn P. (2002). Synthesis of homoceramides, novel ceramide analogues, and their lack of effect on the growth of hippocampal neurons.  Journal of Organic Chemistry. 67:(3)988-996.  Abstract
Pelled D., Raveh T., Riebeling C., Fridkin M., Berissi H., Futerman A. H. & Kimchi A. (2002). Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons.  Journal of Biological Chemistry. 277:(3)1957-1961.  Abstract

2001

Shogomori H. & Futerman A. H. (2001). Cholesterol depletion by methyl-beta-cyclodextrin blocks cholera toxin transport from endosomes to the Golgi apparatus in hippocampal neurons.  Journal of Neurochemistry. 78:(5)991-999.  Abstract
Shogomori H. & Futerman A. H. (2001). Cholera toxin is found in detergent-insoluble rafts/domains at the cell surface of hippocampal neurons but is internalized via a raft-independent mechanism.  Journal of Biological Chemistry. 276:(12)9182-9188.  Abstract
Venkataraman K. & Futerman A. H. (2001). Comparison of the metabolism of L-erythro- and L-threo-sphinganines and ceramides in cultured cells and in subcellular fractions.  Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids. 1530:(3-Feb)219-226.  Abstract

2000

Van Overmeire O. I., Boldin S., Venkataraman K., Zisling R., De Jonghe J. S., Van Calenbergh C. S., De Keukeleire K. D., Futerman A. H. & Herdewijn P. (2000). Synthesis and biological evaluation of ceramide analogues with substituted aromatic rings or an allylic fluoride in the sphingoid moiety.  Journal of Medicinal Chemistry. 43:(22)4189-4199.  Abstract
Venkataraman K. & Futerman A. H. (2000). Ceramide as a second messenger: sticky solutions to sticky problems.  Trends in Cell Biology. 10:(10)408-412.  Abstract
Boldin S. & Futerman A. H. (2000). Up-regulation of glucosylceramide synthesis upon stimulation of axonal growth by basic fibroblast growth factor - Evidence for post-translational modification of glucosylceramide synthase.  Journal of Biological Chemistry. 275:(14)9905-9909.  Abstract
Pelled D., Shogomori H. & Futerman A. H. (2000). The increased sensitivity of neurons with elevated glucocerebroside to neurotoxic agents can be reversed by imiglucerase.  Journal of Inherited Metabolic Disease. 23:(2)175-184.  Abstract
Neuberger Y., Shogomori H., Levy Z., Fainzilber M. & Futerman A. H. (2000). A lyso-platelet activating factor phospholipase C, originally suggested to be a neutral-sphingomyelinase, is located in the endoplasmic reticulum.  FEBS Letters. 469:(1)44-46.  Abstract
Schwarz A., Jurgens L., Licht A., Schneider H., Futerman A. H. & Pecht I. (2000). An IgE-dependent secretory response of mast cells can be induced by a glycosphingolipid-specific monoclonal antibody.  European Journal of Immunology. 30:(1)217-226.  Abstract
Terstappen G., Futerman A. H. & Schwarz A. (2000). Cloud-point extraction of gangliosides using nonionic detergent C14EO6.  Sphingolipid Metabolism And Cell Signaling, Pt B. 312:187-196.
Schwarz A. & Futerman A. H. (2000). Immunolocalization of gangliosides by light microscopy using anti-ganglioside antibodies.  Sphingolipid Metabolism And Cell Signaling, Pt B. 312:179-187.

1999

Brann A., Scott R., Neuberger Y., Abulafia D., Boldin S., Fainzilber M. & Futerman A. H. (1999). Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neurons.  Journal of Neuroscience. 19:(19)8199-8206.  Abstract
Shogomori H., Burack M., Banker G. & Futerman A. H. (1999). Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons.  FEBS Letters. 458:(2)107-111.  Abstract
Levite M., Fleidervish I., Schwarz A., Pelled D. & Futerman A. H. (1999). Autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel.  Journal of Autoimmunity. 13:(1)61-72.  Abstract
Futerman A. H., Boldin S., Brann A., Pelled D., Meivar-Levy I. & Zisling R. (1999). Regulation of sphingolipid and glycosphingolipid metabolism during neuronal growth and development.  Biochemical Society Transactions. 27:(4)432-437.  Abstract
Van Overmeire O. I., Boldin S., Dumont F., Van Calenbergh C. S., Slegers G., De Keukeleire K. D., Futerman A. H. & Herdewijn P. (1999). Effect of aromatic short-chain analogues of ceramide on axonal growth in hippocampal neurons.  Journal of Medicinal Chemistry. 42:(14)2697-2705.  Abstract
Korkotian E., Schwarz A., Pelled D., Schwarzmann G., Segal M. & Futerman A. H. (1999). Elevation of intracellular glucosylceramide levels results in an increase in endoplasmic reticulum density and in functional calcium stores in cultured neurons.  Journal of Biological Chemistry. 274:(31)21673-21678.  Abstract
Naslavsky N., Shmeeda H., Friedlander G., Yanai A., Futerman A. H., Barenholz Y. & Taraboulos A. (1999). Sphingolipid depletion increases formation of the scrapie prion protein in neuroblastoma cells infected with prions.  Journal of Biological Chemistry. 274:(30)20763-20771.  Abstract
Meivar-Levy I. & Futerman A. H. (1999). Up-regulation of neutral glycosphingolipid synthesis upon long term inhibition of ceramide synthesis by fumonisin B-1.  Journal of Biological Chemistry. 274:(8)4607-4612.  Abstract

1998

Khanin R., Segel L. A. & Futerman A. H. (1998). The diffusion of molecules in axonal plasma membranes: the sites of insertion of new membrane molecules and their distribution along the axon surface.  Journal of Theoretical Biology. 193:(3)371-382.  Abstract
Schwarz A. & Futerman A. H. (1998). Inhibition of sphingolipid synthesis, but not degradation, alters the rate of dendrite growth in cultured hippocampal neurons.  Developmental Brain Research. 108:(2-Jan)125-130.  Abstract
Futerman A. H. (1998). The roles of ceramide in the regulation of neuronal growth and development.  Biochemistry-Moscow. 63:(1)74-83.  Abstract
Futerman A. H., Boldin S., Brann A., Schwarz A. & Zisling R. (1998). Regulatory roles for sphingolipids in the growth of polarized neurons.  Sphingolipids As Signaling Modulators In The Nervous System. 845:176-187.  Abstract

1997

Schwarz A., Terstappen G. & Futerman A. H. (1997). Isolation of gangliosides by cloud-point extraction with a nonionic detergent.  Analytical Biochemistry. 254:(2)221-225.  Abstract
Schwarz A. & Futerman A. H. (1997). Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth.  Journal of Neuroscience. 17:(9)2929-2938.  Abstract
Schwarz A. & Futerman A. H. (1997). Determination of the localization of gangliosides using anti-ganglioside antibodies: Comparison of fixation methods.  Journal Of Histochemistry & Cytochemistry. 45:(4)611-618.  Abstract
Samuel N., Wonnacott S., Lindstrom J. & Futerman A. H. (1997). Parallel increases in [alpha-I-125]bungarotoxin binding and alpha 7 nicotinic subunit immunoreactivity during the development of rat hippocampal neurons in culture.  Neuroscience Letters. 222:(3)179-182.  Abstract
Boldin S. & Futerman A. H. (1997). Glucosylceramide synthesis is required for basic fibroblast growth factor and laminin to stimulate axonal growth.  Journal of Neurochemistry. 68:(2)882-885.  Abstract
Meivarlevy I., Sabanay H., Bershadsky A. & Futerman A. H. (1997). The role of sphingolipids in the maintenance of fibroblast morphology - The inhibition of protrusional activity, cell spreading, and cytokinesis induced by fumonisin B-1 can be reversed by ganglioside GM(3).  Journal of Biological Chemistry. 272:(3)1558-1564.  Abstract

1996

Sofer A. & Futerman A. H. (1996). Rate of retrograde transport of cholera toxin from the plasma membrane to the Golgi apparatus and endoplasmic reticulum decreases during neuronal development.  Journal of Neurochemistry. 67:(5)2134-2140.  Abstract
Schwarz A. & Futerman A. H. (1996). The localization of gangliosides in neurons of the central nervous system: The use of anti-ganglioside antibodies.  Biochimica Et Biophysica Acta-Reviews On Biomembranes. 1286:(3)247-267.
Sofer A., Schwarzmann G. & Futerman A. H. (1996). The internalization of a short acyl chain analogue of ganglioside GM(1) in polarized neurons.  Journal of Cell Science. 109:2111-2119.  Abstract
Hirschberg K., Zisling R., Vanechtendeckert G. & Futerman A. H. (1996). Ganglioside synthesis during the development of neuronal polarity - Major changes occur during axonogenesis and axon elongation, but not during dendrite growth or synaptogenesis.  Journal of Biological Chemistry. 271:(25)14876-14882.  Abstract
Futerman A. H. & Banker G. (1996). The economics of neurite outgrowth - The addition of new membrane to growing axons.  Trends in Neurosciences. 19:(4)144-149.  Abstract
Harel R. & Futerman A. H. (1996). A newly-synthesized GPI-anchored protein, TAG-1/axonin-1, is inserted into axonal membranes along the entire length of the axon and not exclusively at the growth cone.  Brain Research. 712:(2)345-348.  Abstract

1995

Futerman A. H. (1995). Inhibition of Sphingolipid Synthesis - Effects on Glycosphingolipid-Gpi-Anchored Protein Microdomains.  Trends in Cell Biology. 5:(10)377-380.  Abstract
Futerman A. H., Hirschberg K., Meivarlevy I., Rapaport E., Schwarz A., Sofer A. & Zisling R. (1995). Vesicle Transport During Cell-Growth and in the Maintenance of Cell Polarity.  Biochemical Society Transactions. 23:(3)530-534.  Abstract
Sofer A. & Futerman A. H. (1995). Cationic Amphiphilic Drugs Inhibit the Internalization of Cholera-Toxin to the Golgi-Apparatus and the Subsequent Elevation of Cyclic-AMP.  Journal of Biological Chemistry. 270:(20)12117-12122.  Abstract
Schwarz A., Rapaport E., Hirschberg K. & Futerman A. H. (1995). A Regulatory Role For Sphingolipids in Neuronal Growth - Inhibition of Sphingolipid Synthesis and Degradation Have Opposite Effects on Axonal Branching.  Journal of Biological Chemistry. 270:(18)10990-10998.  Abstract
Koval M., Futerman A. H. & Pagano R. (1995). Sphingomyelin Synthesis in Endosomal Compartments.  Trends in Cell Biology. 5:(4)148-149.

1994

Meivarlevy I., Horowitz M. & Futerman A. H. (1994). Analysis of Glucocerebrosidase Activity Using n-(1-[c-14]Hexanoyl)-D-Erythro-Glucosylsphingosine Demonstrates a Correlation Between Levels of Residual Enzyme-Activity and the Type of Gaucher Disease.  Biochemical Journal. 303:377-382.  Abstract
Bershadsky A. & Futerman A. H. (1994). Disruption of the Golgi-Apparatus by Brefeldin-a Blocks Cell Polarization and Inhibits Directed Cell-Migration.  Proceedings of the National Academy of Sciences of the United States of America. 91:(12)5686-5689.  Abstract
Futerman A. H. (1994). Ceramide Metabolism Compartmentalized in the Endoplasmic-Reticulum and Golgi-Apparatus.  Cell Lipids. 40:93-110.

1993

Boudker O. & Futerman A. H. (1993). Detection and Characterization of Ceramide-1-Phosphate Phosphatase-Activity in Rat-Liver Plasma-Membrane.  Journal of Biological Chemistry. 268:(29)22150-22155.  Abstract
Harel R. & Futerman A. H. (1993). Inhibition of Sphingolipid Synthesis Affects Axonal Outgrowth in Cultured Hippocampal-Neurons.  Journal of Biological Chemistry. 268:(19)14476-14481.  Abstract
Futerman A. H., Khanin R. & Segel L. (1993). Lipid Diffusion in Neurons.  Nature. 362:(6416)119-119.
Hirschberg K., Rodger J. & Futerman A. H. (1993). The Long-Chain Sphingoid Base of Sphingolipids is Acylated at the Cytosolic Surface of the Endoplasmic-Reticulum in Rat-Liver.  Biochemical Journal. 290:751-757.  Abstract

1992

Futerman A. H. & Pagano R. (1992). Use of n-([1-c-14]Hexanoyl)-Deuterium-Erythro-Sphingolipids to Assay Sphingolipid Metabolism.  Methods in Enzymology. 209:437-446.

1988

Sussman J., Harel M., Frolow F., Varon L., Toker L., Futerman A. H. & Silman I. (1988). Purification And Crystallization Of A Dimeric Form Of Acetylcholinesterase From Torpedo-Californica Subsequent To Solubilization With Phosphatidylinositol-Specific Phospholipase-C.  Journal of Molecular Biology. 203:(3)821-822.
Inestrosa N., Fuentes M., Anglister L., Futerman A. H. & Silman I. (1988). A Membrane-Associated Dimer of Acetylcholinesterase from Xenopus Skeletal-Muscle is Solubilized by Phosphatidylinositol-Specific Phospholipase-c.  Neuroscience Letters. 90:(2-Jan)186-190.

1987

Silman I. & Futerman A. H. (1987). Modes of Attachment of Acetylcholinesterase to the Surface-Membrane.  FEBS Journal. 170:(2-Jan)11-22.
Futerman A. H., Raviv D., Michaelson D. & Silman I. (1987). Differential Susceptibility to Phosphatidylinositol-Specific Phospholipase-c of Acetylcholinesterase in Excitable Tissues of Embryonic and Adult Torpedo-Ocellata.  Molecular Brain Research. 2:(2)105-112.
Low M., Futerman A. H., Ackermann K., Sherman W. & Silman I. (1987). Removal of Covalently Bound Inositol from Torpedo Acetylcholinesterase and Mammalian Alkaline-Phosphatases by Deamination With Nitrous-Acid - Evidence For a Common Membrane-Anchoring Structure.  Biochemical Journal. 241:(2)615-619.
Silman I. & Futerman A. H. (1987). Posttranslational Modification as a Means of Anchoring Acetylcholinesterase to the Cell-Surface.  Biopolymers. 26:S241-S253.

1986

Low M., Ferguson M., Futerman A. H. & Silman I. (1986). Covalently Attached Phosphatidylinositol as a Hydrophobic Anchor For Membrane-Proteins.  Trends in Biochemical Sciences. 11:(5)212-215.

1985

Barton P., Futerman A. H. & Silman I. (1985). Arrhenius Plots of Acetylcholinesterase Activity in Mammalian Erythrocytes and in Torpedo Electric Organ - Effect of Solubilization by Proteinases and by a Phosphatidylinositol-Specific Phospholipase-c.  Biochemical Journal. 231:(1)237-240.
Futerman A. H., Fiorini R., Roth E., Low M. & Silman I. (1985). Physicochemical Behavior and Structural Characteristics of Membrane-Bound Acetylcholinesterase from Torpedo Electric Organ - Effect of Phosphatidylinositol-Specific Phospholipase-c.  Biochemical Journal. 226:(2)369-377.
Futerman A. H., Low M., Ackermann K., Sherman W. & Silman I. (1985). Identification of Covalently Bound Inositol in the Hydrophobic Membrane-Anchoring Domain of Torpedo Acetylcholinesterase.  Biochemical and Biophysical Research Communications. 129:(1)312-317.
Futerman A. H., Low M., Michaelson D. & Silman I. (1985). Solubilization of Membrane-Bound Acetylcholinesterase by a Phosphatidylinositol-Specific Phospholipase-c.  Journal of Neurochemistry. 45:(5)1487-1494.

1983

Futerman A. H., Low M. & Silman I. (1983). A Hydrophobic Dimer of Acetylcholinesterase from Torpedo-Californica Electric Organ is Solubilized by Phosphatidylinositol-Specific Phospholipase-c.  Neuroscience Letters. 40:(1)85-89.