Publications

  • Galanos P., Pappas G., Polyzos A., Kotsinas A., Svolaki I., Giakoumakis N. N., Glytsou C., Pateras I. S., Swain U., Souliotis V. L., Georgakilas A. G., Geacintov N., Scorrano L., Lukas C., Lukas J., Livneh Z., Lygerou Z., Chowdhury D., SøRensen C. S., Bartek J. & Gorgoulis V. G. (2022). Author Correction: Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability (Genome Biology, (2018), 19, 1, (37), 10.1186/s13059-018-1401-9).  Genome Biology. 23.
  • Hirota K., Tsuda M., Tsurimoto T., Cohen I. S., Livneh Z., Kobayashi K., Narita T., Nishihara K., Murai J., Iwai S., Guilbaud G., Sale J. E. & Takeda S. (2016). In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.  Nucleic Acids Research. 44:(15)7242-7250.
  • Sevilya Z., Leitner Dagan Y., Pinchev M., Kremer R., Elinger D., Lejbkowicz F., Rennert H. S., Freedman L. S., Rennert G., Paz-Elizur T. & Livneh Z. (2015). Development of APE1 enzymatic DNA repair assays: Low APE1 activity is associated with increase lung cancer risk.  Carcinogenesis. 36:(9)982-991.
  • Shriber P., Leitner-Dagan Y., Geacintov N., Paz-Elizur T. & Livneh Z. (2015). DNA sequence context greatly affects the accuracy of bypass across an ultraviolet light 6-4 photoproduct in mammalian cells.  Mutation research. 780:71-76.
  • Sevilya Z., Leitner Dagan Y., Pinchev M., Kremer R., Elinger D., Rennert H. S., Schechtman E., Freedman L. S., Rennert G., Paz-Elizur T. & Livneh Z. (2014). Low integrated DNA repair score and lung cancer risk.  Cancer Prevention Research. 7:(4)398-406.
  • Leitner Dagan Y., Sevilya Z., Pinchev M., Kramer R., Elinger D., Roisman L. C., Rennert H. S., Schechtman E., Freedman L., Rennert G., Livneh Z. & Paz-Elizur T. (2012). N-methylpurine DNA glycosylase and OGG1 DNA repair activities: Opposite associations with lung cancer risk.  Journal of the National Cancer Institute. 104:(22)1765-1769.
  • Hendel A., Krijger P. H. L., Diamant N., Goren Z., Langerak P., Kim J., Reissner T., Lee K., Geacintov N. E., Carell T., Myung K., Tateishi S., D'Andrea A., Jacobs H. & Livneh Z. (2011). PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells.  PLoS Genetics. 7:(9)
  • Schneider S., ReißNer T., Ziv O., Livneh Z. & Carell T. (2010). Translesion synthesis of 1,3-GTG sisplatin DNA lesions.  ChemBioChem. 11:(11)1521-1524.
  • Ziv O., Geacintov N., Nakajima S., Yasui A. & Livneh Z. (2009). DNA polymerase ζ cooperates with polymerases κ and ι in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients.  Proceedings of the National Academy of Sciences of the United States of America. 106:(28)11552-11557.
  • Jansen J. G., Tsaalbi-Shtylik A., Hendriks G., Gali H., Hendel A., Johansson F., Erixon K., Livneh Z., Mullenders L. H., Haracska L. & De Wind N. (2009). Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.  Molecular and Cellular Biology. 29:(11)3113-3123.
  • Hendel A., Ziv O., Gueranger Q., Geacintov N. & Livneh Z. (2008). Reduced efficiency and increased mutagenicity of translesion DNA synthesis across a TT cyclobutane pyrimidine dimer, but not a TT 6-4 photoproduct, in human cells lacking DNA polymerase η.  DNA Repair. 7:(10)1636-1646.
  • Izhar L., Goldsmith M., Dahan R., Geacintov N., Lloyd R. G. & Livneh Z. (2008). Analysis of Strand Transfer and Template Switching Mechanisms of DNA Gap Repair by Homologous Recombination in Escherichia coli: Predominance of Strand Transfer.  Journal of Molecular Biology. 381:(4)803-809.
  • Avkin S., Sevilya Z., Toube L., Geacintov N., Chaney S., Oren M. & Livneh Z. (2006). p53 and p21 Regulate Error-Prone DNA Repair to Yield a Lower Mutation Load.  Molecular Cell. 22:(3)407-413.
  • Livneh Z. (2006). Keeping mammalian mutation load in check: Regulation of the activity of error-prone DNA polymerases by p53 and p21.  Cell Cycle. 5:(17)1918-1922.
  • Avkin S., Goldsmith M., Velasco-Miguel S., Geacintov N., Friedberg E. & Livneh Z. (2004). Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: The role of DNA polymerase.  Journal of Biological Chemistry. 279:(51)53298-53305.
  • Covo S., Blanco L. & Livneh Z. (2004). Lesion Bypass by Human DNA Polymerase μ Reveals a Template-dependent, Sequence-independent Nucleotidyl Transferase Activity.  Journal of Biological Chemistry. 279:(2)859-865.
  • Berdichevsky A., Izhar L. & Livneh Z. (2002). Error-free recombinational repair predominates over mutagenic translesion replication in E. Coli.  Molecular Cell. 10:(4)917-924.
  • Livneh Z. (2001). DNA Damage Control by Novel DNA Polymerases: Translesion Replication and Mutagenesis.  Journal of Biological Chemistry. 276:(28)25639-25642.
  • Ohmori H., Friedberg E., Fuchs R., Goodman M., Hanaoka F., Hinkle D., Kunkel T., Lawrence C., Livneh Z., Nohmi T., Prakash L., Prakash S., Todo T., Walker G., Wang Z. & Woodgate R. (2001). The Y-family of DNA Polymerases.  Molecular Cell. 8:(1)7-8.
  • Goldsmith M., Sarov-Blat L. & Livneh Z. (2000). Plasmid-encoded MucB protein is a DNA polymerase (pol RI) specialized for lesion bypass in the presence of MucA', RecA, and SSB.  Proceedings of the National Academy of Sciences of the United States of America. 97:(21)11227-11231.
  • Daube S., Arad G. & Livneh Z. (2000). Translesion replication by DNA polymerase β is modulated by sequence context and stimulated by fork-like flap structures in DNA.  Biochemistry. 39:(2)397-405.
  • Daube S., Tomer G. & Livneh Z. (2000). Translesion replication by DNA polymerase δ depends on processivity accessory proteins and differs in specificity from DNA polymerase β.  Biochemistry. 39:(2)348-355.
  • Reuven N., Arad G., Maor-Shoshani A. & Livneh Z. (1999). The mutagenesis protein UmuC is a DNA polymerase activated by UmuD', RecA, and SSB and is specialized for translesion replication.  Journal of Biological Chemistry. 274:(45)31763-31766.
  • Tomer G., Reuven N. B. & Livneh Z. (1998). The β subunit sliding DNA clamp is responsible for unassisted mutagenic translesion replication by DNA polymerase III holoenzyme.  Proceedings of the National Academy of Sciences of the United States of America. 95:(24)14106-14111.
  • Dahan-Grobgeld E., Livneh Z., Maretzek A., Polak-Charcon S., Eichenbaum Z. & Degani H. (1998). Reversible induction of ATP synthesis by DNA damage and repair in Escherichia coli: In vivo NMR studies.  Journal of Biological Chemistry. 273:(46)30232-30238.
  • Sarov-Blat L. & Livneh Z. (1998). The mutagenesis protein MucB interacts with single strand DNA binding protein and induces a major conformational change in its complex with single- stranded DNA.  Journal of Biological Chemistry. 273:(10)5520-5527.
  • Reuven N. B., Tomer G. & Livneh Z. (1998). The mutagenesis proteins UmuD′ and UmuC prevent lethal frameshifts while increasing base substitution mutations.  Molecular Cell. 2:(2)191-199.
  • Dror Levinsky M., Brenner B., Yalon M., Levi Z., Livneh Z., Cohen Z., Paz-Elizur T., Grossman R., Ram Z. & Volovitz I. (2023). A Highly Sensitive Flow Cytometric Approach to Detect Rare Antigen-Specific T Cells: Development and Comparison to Standard Monitoring Tools.  Cancers. 15:(3)
  • Cohen Y., Bamberger N., Mor O., Walfisch R., Fleishon S., Varkovitzky I., Younger A., Levi D. O., Kohn Y., Steinberg D. M., Zeevi D., Erster O., Mendelson E. & Livneh Z. (2022). Effective bubble-based testing for SARS-CoV-2 using swab-pooling.  Clinical Microbiology and Infection. 28:(6)859-864.
  • Swain U., Friedlander G., Sehrawat U., Sarusi-Portuguez A., Rotkopf R., Ebert C., Paz-Elizur T., Dikstein R., Carell T., Geacintov N. E. & Livneh Z. (2021). TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer.  International Journal of Molecular Sciences. 22:(13)
  • Oved K., Olmer L., Shemer-Avni Y., Wolf T., Supino-Rosin L., Prajgrod G., Shenhar Y., Payorsky I., Cohen Y., Kohn Y., Indenbaum V., Lazar R., Geylis V., Oikawa M. T., Shinar E., Stoyanov E., Keinan-Boker L., Bassal R., Reicher S., Yishai R., Bar-Chaim A., Doolman R., Reiter Y., Mendelson E., Livneh Z., Freedman L. S. & Lustig Y. (2020). Multi-center nationwide comparison of seven serology assays reveals a SARS-CoV-2 non-responding seronegative subpopulation.  EClinicalMedicine. 29-30.
  • Erster O., Shkedi O., Benedek G., Zilber E., Varkovitzky I., Shirazi R., Oriya Shorka D., Cohen Y., Bar T., Yechieli R., Tepperberg Oikawa M., Venkert D., Linial M., Oiknine-Djian E., Mandelboim M., Livneh Z., Shenhav-Saltzman G., Mendelson E., Wolf D., Szwarcwort-Cohen M., Mor O., Lewis Y. & Zeevi D. (2021). Improved sensitivity, safety, and rapidity of COVID-19 tests by replacing viral storage solution with lysis buffer.  PLoS ONE. 16:(3)-.
  • Feldman T., Bercovich A., Moskovitz Y., Chapal-Ilani N., Mitchell A., Medeiros J. J. F., Biezuner T., Kaushansky N., Minden M. D., Gupta V., Milyavsky M., Livneh Z., Tanay A. & Shlush L. I. (2021). Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining.  Nature Communications. 12:(1)
  • Ziv O., Zeisel A., Mirlas-Neisberg N., Swain U., Nevo R., Ben Chetrit C. N., Martelli M. P., Rossi R., Schiesser S., Canman C. E., Carell T., Geacintov N. E., Falini B., Domany E. & Livneh Z. (2014). Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin.  Nature Communications. 5.
  • Izhar L., Ziv O., Cohen I. S., Geacintov N. E. & Livneh Z. (2013). Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells.  Proceedings of the National Academy of Sciences of the United States of America. 110:(16)E1462-E1469.
  • Diamant N., Hendel A., Vered I., Carell T., Reissner T., De Wind W. N., Geacinov N. & Livneh Z. (2012). DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity.  Nucleic Acids Research. 40:(1)170-180.
  • Livneh Z., Ziv O. & Shachar S. (2010). Multiple two-polymerase mechanisms in mammalian translesion DNA synthesis.  Cell Cycle. 9:(4)729-735.
  • Adar S., Izhar L., Hendel A., Geacintov N. & Livneh Z. (2009). Repair of gaps opposite lesions by homologous recombination in mammalian cells.  Nucleic Acids Research. 37:(17)5737-5748.
  • Shachar S., Ziv O., Avkin S., Adar S., Wittschieben J., Reissner T., Chaney S., Friedberg E. C., Wang Z., Carell T., Geacintov N. & Livneh Z. (2009). Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals.  EMBO Journal. 28:(4)383-393.
  • Paz-Elizur T., Sevilya Z., Leitner Dagan Y., Elinger D., Roisman L. C. & Livneh Z. (2008). DNA repair of oxidative DNA damage in human carcinogenesis: Potential application for cancer risk assessment and prevention.  Cancer Letters. 266:(1)60-72.
  • Paz-Elizur T., Elinger D., Leitner Dagan Y., Blumenstein S., Krupsky M., Berrebi A., Schechtman E. & Livneh Z. (2007). Development of an enzymatic DNA repair assay for molecular epidemiology studies: Distribution of OGG activity in healthy individuals.  DNA Repair. 6:(1)45-60.
  • Benenson Y., Adar R., Paz-Elizur T., Livneh Z. & Shapiro E. (2003). DNA molecule provides a computing machine with both data and fuel.  Proceedings of the National Academy of Sciences of the United States of America. 100:(5)2191-2196.
  • Paz-Elizur T., Krupsky M., Blumenstein S., Elinger D., Schechtman E. & Livneh Z. (2003). DNA repair activity for oxidative damage and risk of lung cancer.  Journal of the National Cancer Institute. 95:(17)1312-1319.
  • Benenson Y., Paz-Elizur T., Adar R., Keinan E., Livneh Z. & Shapiro E. (2001). Programmable and autonomous computing machine made of biomolecules.  Nature. 414:(6862)430-434.
  • Maor-Shoshani A., Reuven N. B., Tomer G. & Livneh Z. (2000). Highly mutagenic replication by DNA polymerase V (UmuC) provides a mechanistic basis for SOS untargeted mutagenesis.  Proceedings of the National Academy of Sciences of the United States of America. 97:(2)565-570.
  • Offer H., Wolkowicz R., Matas D., Blumenstein S., Livneh Z. & Rotter V. (1999). Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery.  FEBS Letters. 450:(3)197-204.
  • Avkin S., Adar S., Blander G. & Livneh Z. (2002). Quantitative measurement of translesion replication in human cells: Evidence for bypass of abasic sites by a replicative DNA polymerase.  Proceedings of the National Academy of Sciences of the United States of America. 99:(6)3764-3769.
  • Paz-Elizur T., Leitner-Dagan Y., Meyer K. B., Markus B., Giorgi F. M., O'Reilly M., Kim H., Evgy Y., Fluss R., Freedman L. S., Rintoul R. C., Ponder B. & Livneh Z. (2020). DNA Repair Biomarker for Lung Cancer Risk and its Correlation With Airway Cells Gene Expression.  Jnci cancer spectrum. 4:(1)
  • Galanos P., Pappas G., Polyzos A., Kotsinas A., Svolaki I., Giakoumakis N. N., Glytsou C., Pateras I. S., Swain U., Souliotis V. L., Georgakilas A. G., Geacintov N., Scorrano L., Lukas C., Lukas J., Livneh Z., Lygerou Z., Chowdhury D., Sorensen C. S., Bartek J. & Gorgoulis V. G. (2018). Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.  Genome Biology. 19:(1)
  • Livneh Z., Cohen I. S., Paz-Elizur T., Davidovsky D., Carmi D., Swain U. & Mirlas-Neisberg N. (2016). High-resolution genomic assays provide insight into the division of labor between TLS and HDR in mammalian replication of damaged DNA.  DNA Repair. 44:59-67.
  • Cohen I. S., Bar C., Paz-Elizur T., Ainbinder E., Leopold K., De Wind N., Geacintov N. & Livneh Z. (2015). DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes.  Nucleic Acids Research. 43:(3)1637-1645.
  • Leitner Dagan Y., Sevilya Z., Pinchev M., Kremer R., Elinger D., Rennert H. S., Schechtman E., Freedman L., Rennert G., Livneh Z. & Paz-Elizur T. (2014). Enzymatic MPG DNA repair assays for two different oxidative DNA lesions reveal associations with increased lung cancer risk.  Carcinogenesis. 35:(12)2763-2770.
  • Covo S., De Villartay J., Jeggo P. A. & Livneh Z. (2009). Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells.  Nucleic Acids Research. 37:(20)6737-6745.
  • Leloup C., Garty G., Assaf G., Cristovao A., Breskin A., Chechik R., Shchemelinin S., Paz-Elizur T., Livneh Z., Schulte R., Bashkirov V., Milligan J. & Grosswendt B. (2005). Evaluation of lesion clustering in irradiated plasmid DNA.  International Journal of Radiation Biology. 81:(1)41-54.
  • Maor-Shoshani A., Ben-Ari V. & Livneh Z. (2003). Lesion bypass DNA polymerases replicate across non-DNA segments.  Proceedings of the National Academy of Sciences of the United States of America. 100:(25)14760-14765.
  • Maor-Shoshani A., Hayashi K., Ohmori H. & Livneh Z. (2003). Analysis of translesion replication across an abasic site by DNA polymerase IV of Escherichia coli.  DNA Repair. 2:(11)1227-1238.
  • Maor-Shoshani A. & Livneh Z. (2002). Analysis of the stimulation of DNA polymerase V of Escherichia coli by processivity proteins.  Biochemistry. 41:(48)14438-14446.
  • Tomer G. & Livneh Z. (1999). Analysis of unassisted translesion replication by the DNA polymerase III holoenzyme.  Biochemistry. 38:(18)5948-5958.
  • Paz-Elizur T., Ben-Yosef R., Elinger D., Vexler A., Krupsky M., Berrebi A., Shani A., Schechtman E., Freedman L. & Livneh Z. (2006). Reduced repair of the oxidative 8-oxoguanine DNA damage and risk of head and neck cancer.  Cancer Research. 66:(24)11683-11689.
  • Paz-Elizur T., Brenner D. E. & Livneh Z. (2005). Interrogating DNA repair in cancer risk assessment.  Cancer Epidemiology Biomarkers & Prevention. 14:(7)1585-1587.
  • Avkin S. & Livneh Z. (2002). Efficiency, specificity and DNA polymerase-dependence of translesion replication across the oxidative DNA lesion 8-oxoguanine in human cells.  Mutation Research-Fundamental And Molecular Mechanisms Of Mutagenesis. 510:(1-2)81-90.
  • Reuven N., Arad G., Stasiak A., Stasiak A. & Livneh Z. (2001). Lesion bypass by the Escherichia coli DNA polymerase V requires assembly of a RecA nucleoprotein filament.  Journal of Biological Chemistry. 276:(8)5511-5517.
  • Arad G., Hendel A., Urbanke C., Curth U. & Livneh Z. (2008). Single-stranded DNA-binding protein recruits DNA polymerase V to primer termini on RecA-coated DNA.  Journal of Biological Chemistry. 283:(13)8274-8282.
  • Adar S. & Livneh Z. (2006). Translesion DNA synthesis across non-DNA segments in cultured human cells.  DNA Repair. 5:(4)479-490.
  • Eichenbaum Z. & Livneh Z. (1998). UV light induces IS10 transposition in Escherichia coli.  Genetics. 149:(3)1173-1181.

Earlier Publications