The biggest challenge in cancer therapy is the development of resistance. Our group studies the evolutionary forces that drive therapy resistance formation, in order to identify targetable vulnerabilities. We focus on mechanisms of DNA repair that enable ecDNA amplifications in cancer progression and resistance formation and explore different approaches to target the formation and evolution of ecDNA. Our vision is to develop a combination therapy approach that targets cancer cells survival and in parallel inhibits the evolutionary potential that often leads to resistance formation.
Chromosome Catastrophes in Cancer
