Publications

  1. Arpinati L,  Scherz-Shouval, R., From gatekeepers to providers: regulation of immune functions by cancer-associated fibroblasts. Trends in Cancer. (2023). DOI: 10.1016/j.trecan.2023.01.007
  2. Hey J, Halperin C, Hartmann M, Mayer S, Schönung M, Lipka D.B, Scherz-Shouval, R. and Plass C. , DNA methylation landscape of tumor-associated macrophages reveals pathways, transcription factors, and prognostic value relevant to triple-negative breast cancer patients. Int. J. Cancer.  (2023). DOI: 10.1002/ijc.34364
  3. Halperin C, Hey J, Weichenhan D, Stein Y, Mayer S, Lutsik P, Plass C, Scherz-Shouval R. Global DNA Methylation Analysis of Cancer-Associated Fibroblasts Reveals Extensive Epigenetic Rewiring Linked with RUNX1 Upregulation in Breast Cancer Stroma. Cancer Res (2022) 82 (22): 4139–4152. DOI: 10.1158/0008-5472.CAN-22-0209
  4. Shaashua L , Ben-Shmuel A, Pevsner-Fischer M & Scherz-Shouval R. BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling. Nat Commun 13, 6513 (2022). DOI: 10.1038/s41467-022-34081-3
  5. Lavie D , Ben-Shmuel A , Erez N & Scherz-Shouval R. Cancer-associated fibroblasts in the single-cell era. Nat Cancer 3, 793–807 (2022). DOI: 10.1038/s43018-022-00411-z

  6. Shani O, Raz Y, Monteran L, Scharff Y, Levi-Galibov O, Megides O, Shacham H, Cohen N, Silverbush D, Avivi C, Sharan R, Madi A, Scherz-Shouval R., Barshack I, Tsarfaty I, Erez N. Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity. Elife. 2021 Jun 25;10:e60745. DOI: 10.7554/eLife.60745.

  7. Grunberg N, Pevsner-Fischer M, Goshen-Lago T, Diment J, Stein Y, Lavon H, Mayer S, Levi-Galibov O, Friedman G, Ofir-Birin Y, Syu LJ, Migliore C, Shimoni E, Stemmer SM, Brenner B, Dlugosz AA, Lyden D, Regev-Rudzki N, Ben-Aharon I, Scherz-Shouval R. Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1-Mediated Secretion of Extracellular Vesicles. Cancer Res. 2021 Apr 1;81(7):1639-1653. DOI: 10.1158/0008-5472.CAN-20-2756.

  8. Levi-Galibov O, Lavon H, Wassermann-Dozorets R, Pevsner-Fischer M, Mayer S, Wershof E, Stein Y, Brown LE, Zhang W, Friedman G, Nevo R, Golani O, Katz LH, Yaeger R, Laish I, Porco JA, Sahai E, Shouval DS, Kelsen D, Scherz-Shouval R. Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer. Nat Commun. 2020 Dec 7;11(1):6245. DOI: 10.1038/s41467-020-20054-x. 

  9. Shaashua L, Mayer S, Lior C, Lavon H, Novoselsky A, Scherz-Shouval R. Stromal Expression of the Core Clock Gene Period 2Is Essential for Tumor Initiation and Metastatic Colonization. Front Cell Dev Biol. 2020 Oct 2;8:587697. DOI: 10.3389/fcell.2020.587697. 

  10. Vickman RE, Faget DV, Beachy P, Beebe D, Bhowmick NA, Cukierman E, Deng WM, Granneman JG, Hildesheim J, Kalluri R, Lau KS, Lengyel E, Lundeberg J, Moscat J, Nelson PS, Pietras K, Politi K, Puré E, Scherz-Shouval R, Sherman MH, Tuveson D, Weeraratna AT, White RM, Wong MH, Woodhouse EC, Zheng Y, Hayward SW, Stewart SA. Deconstructing tumor heterogeneity: the stromal perspective. Oncotarget. 2020 Oct 6;11(40):3621-3632. DOI: 10.18632/oncotarget.27736. 

  11. Hoshino A, Kim HS, Bojmar L, Gyan KE, Cioffi M, Hernandez J, Zambirinis CP, Rodrigues G, Molina H, Heissel S, Mark MT, Steiner L, Benito-Martin A, Lucotti S, Di Giannatale A, Offer K, Nakajima M, Williams C, Nogués L, Pelissier Vatter FA, Hashimoto A, Davies AE, Freitas D, Kenific CM, Ararso Y, Buehring W, Lauritzen P, Ogitani Y, Sugiura K, Takahashi N, Alečković M, Bailey KA, Jolissant JS, Wang H, Harris A, Schaeffer LM, García-Santos G, Posner Z, Balachandran VP, Khakoo Y, Raju GP, Scherz A, Sagi I, Scherz-Shouval R, Yarden Y, Oren M, Malladi M, Petriccione M, De Braganca KC, Donzelli M, Fischer C, Vitolano S, Wright GP, Ganshaw L, Marrano M, Ahmed A, DeStefano J, Danzer E, Roehrl MHA, Lacayo NJ, Vincent TC, Weiser MR, Brady MS, Meyers PA, Wexler LH, Ambati SR, Chou AJ, Slotkin EK, Modak S, Roberts SS, Basu EM, Diolaiti D, Krantz BA, Cardoso F, Simpson AL, Berger M, Rudin CM, Simeone DM, Jain M, Ghajar CM, Batra SK, Stanger BZ, Bui J, Brown KA, Rajasekhar VK, Healey JH, de Sousa M, Kramer K, Sheth S, Baisch J, Pascual V, Heaton TE, La Quaglia MP, Pisapia DJ, Schwartz R, Zhang H, Liu Y, Shukla A, Blavier L, DeClerck YA, LaBarge M, Bissell MJ, Caffrey TC, Grandgenett PM, Hollingsworth MA, Bromberg J, Costa-Silva B, Peinado H, Kang Y, Garcia BA, O'Reilly EM, Kelsen D, Trippett TM, Jones DR, Matei IR, Jarnagin WR, Lyden D. Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell. 2020 Aug 20;182(4):1044-1061.e18. DOI: 10.1016/j.cell.2020.07.009. 

  12. Gil Friedman, Oshrat Levi-Galibov, Eyal David, Chamutal Bornstein, Amir Giladi, Maya Dadiani, Avi Mayo, Coral Halperin, Meirav Pevsner-Fischer, Hagar Lavon, Reinat Nevo, Yaniv Stein, H. Raza Ali, Carlos Caldas, Einav Nili-Gal-Yam, Uri Alon, Ido Amit and Ruth Scherz-Shouval. (2020). "Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4+ and PDPN+ CAFs to clinical outcome" Nat. Cancer, DOI: 10.1038/s43018-020-0082-y

  13. Grunberg N, Levi-Galibov O, Scherz-Shouval R.  (2020). "The Role of HSF1 and the Chaperone Network in the Tumor Microenvironment.".  Adv Exp Med Biol. 2020;1243:101-111. DOI: 10.1007/978-3-030-40204-4_7.
  14. Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z. (2020). "A framework for advancing our understanding of cancer-associated fibroblasts." Nat Rev Cancer. 2020 Mar;20(3):174-186. DOI: 10.1038/s41568-019-0238-1.
  15. Miles J, Scherz-Shouval R, van Oosten-Hawle P. (2019). "Expanding the Organismal Proteostasis Network: Linking Systemic Stress Signaling with the Innate Immune Response." Trends Biochem Sci., 44 (11): 927-942. DOI: 10.1016/j.tibs.2019.06.009.
  16. Bagley AF, Scherz-Shouval R, Galie PA, Zhang AQ, Wyckoff J, Whitesell L, Chen CS, Lindquist S, and Bhatia SN. (2015). “Endothelial thermotolerance impairs nanoparticle transport in tumors”. Cancer Res., 75 (16): 3255-67. DOI: 10.1158/0008-5472.CAN-15-0325.
  17. Scherz-Shouval R, Santagata S, Mendillo ML, Sholl LM, Ben-Aharon I, Beck AH, Dias-Santagata D, Koeva M, Stemmer SM, Whitesell L, and Lindquist S. (2014). “The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy”. Cell, 158 (3): 564-78. DOI: 10.1016/j.cell.2014.05.045. See also preview: Nat. Rev. Cancer, 2014; 14 (9): 579. DOI: 10.1038/nrc3807.
  18. Kithsiri Wijeratne EM, Xu YM, Scherz-Shouval R, Marron MT, Rocha DD, Liu MX, Costa-Lotufo LV, Santagata S, Lindquist S, Whitesell L, and Leslie Gunatilaka AA. (2014). “Structure-activity relationships for withanolides as inducers of the cellular heat-shock response”. J. Med. Chem., 57 (7): 2851-63. DOI: 10.1021/jm401279n.
  19. Vincent BM, Lancaster AK, Scherz-Shouval R, Whitesell L, and Lindquist S. (2013). "Fitness trade-offs restrict the evolution of resistance to amphotericin B”. PLOS Biol., 11 (10): e1001692. DOI: 10.1371/journal.pbio.1001692.
  20. Scherz-Shouval R, and Elazar Z. (2011). “Regulation of autophagy by ROS: physiology and pathology”. Trends Biochem. Sci., 36 (1): 30-8. DOI: 10.1016/j.tibs.2010.07.007.
  21. Scherz-Shouval R, Weidberg H, Gonen C, Wilder S, Elazar Z and Oren M. (2010). “p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation”. Proc. Natl. Acad. Sci. U.S.A., 107 (43): 18511-6. DOI: 10.1073/pnas.1006124107.
  22. Scherz-Shouval R, and Elazar Z. (2009). “Monitoring starvation-induced reactive oxygen species formation”. Methods Enzymol., 452: 119-30. DOI: 10.1016/S0076-6879(08)03608-2.
  23. Shvets E, Fass E, Scherz-Shouval R, and Elazar Z. (2008). “The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes”. J. Cell Sci., 121 (16): 2685-95. DOI: 10.1242/jcs.026005.
  24. Scherz-Shouval R, and Elazar Z. (2007). “ROS, mitochondria and the regulation of autophagy". Trends Cell Biol., 17 (9): 422-7. DOI: 10.1016/j.tcb.2007.07.009.
  25. Scherz-Shouval R, Shvets E, and Elazar Z. (2007). “Oxidation as a post-translational modification that regulates autophagy”. Autophagy, 3 (4): 371-3. DOI: 10.4161/auto.4214.
  26. Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, and Elazar Z. (2007). “Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4”. EMBO J., 26 (7): 1749-60. DOI: 10.1038/sj.emboj.7601623. See also preview: Dev. Cell, 2007; 12 (4): 484-5. DOI: 10.1016/j.devcel.2007.03.016.
  27. Elazar Z, Scherz-Shouval R, and Shorer H. (2003). "Involvement of LMA1 and GATE-16 family members in intracellular membrane dynamics". Biochim. Biophys. Acta, 1641 (2-3): 145-56. DOI: 10.1016/S0167-4889(03)00086-7.
  28. Scherz-Shouval R, Sagiv Y, Shorer H, and Elazar Z. (2003). "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A". J. Biol. Chem., 278 (16): 14053-8. DOI: 10.1074/jbc.M212108200.
  29. Scherz R, Shinder V, and Engelberg D. (2001). "Anatomical analysis of Saccharomyces cerevisiae stalk-like structures reveals spatial organization and cell specialization". J. Bacteriol., 183 (18): 5402-13. DOI: JB.183.18.5402-5413.2001.