Shifra Lansky Lab

Visualizing Membrane Proteins in Action


The overall goal of our lab is to understand comprehensively the mechanisms by which membrane proteins operate. We believe that “seeing is comprehending”, and therefore, we aim to:

  1. Visualize to atomic resolution the 3D structures of the membrane proteins. 
  2. Video, on a single-molecule level, the motions of these membrane proteins as they function, either alone or through interactions with other proteins. 
  3. Understand how the structures and dynamics of the membrane proteins assist their functional activity.

We use cutting-edge techniques that allow us to achieve these goals, most particularly, high-speed atomic force microscopy (HS-AFM), cryo-electron microscopy (cryo-EM), and an array of complementary biochemical and biophysical techniques.


Research page

Selected Publications

A pentameric TRPV3 channel with a dilated pore

Lansky S., Betancourt J. M., Zhang J., Jiang Y., Kim E. D., Paknejad N., Nimigean C. M., Yuan P. & Scheuring S. (2023) Nature. 621, 7977, p. 206-214

Integrative structure determination reveals functional global flexibility for an ultra-multimodular arabinanase

Lansky S., Salama R., Biarnés X., Shwartstein O., Schneidman-Duhovny D., Planas A., Shoham Y. & Shoham G. (2022) Communications Biology. 5, 465.

Localization atomic force microscopy

Heath G. R., Kots E., Robertson J. L., Lansky S., Khelashvili G., Weinstein H. & Scheuring S. (2021) Nature. 594, 7863, p. 385-390
All Publications