Research
The overall goal of our lab is to understand comprehensively the mechanisms by which membrane proteins operate. We believe that “seeing is comprehending”, and therefore, we aim to:
- Visualize to atomic resolution the 3D structures of the membrane proteins.
- Video, on a single-molecule level, the motions of these membrane proteins as they function, either alone or through interactions with other proteins.
- Understand how the structures and dynamics of the membrane proteins assist their functional activity.
We use cutting-edge techniques that allow us to achieve these goals, most particularly, high-speed atomic force microscopy (HS-AFM), cryo-electron microscopy (cryo-EM), and an array of complementary biochemical and biophysical techniques.
Research page