Active Microtubule Nematics and Gels
Microtubule-based active gels
Microtubule-based active gels
We study how cytoskeletal forces and flows reshape biomolecular condensates, focusing on tau-rich droplets and their mechanical regulation in vitro. In parallel, we utilize DNA nanotechnology to construct multi-arm DNA molecules that undergo liquid-liquid phase separation, enabling precise control over droplet formation and properties across a wide parameter space.
We use DNA networks and biomolecular condensates as model systems to reveal how phase transitions emerge and change when matter is driven far from equilibrium by active forces.
To address the challenge of designing autonomous responsive materials, we aim to implement self-regulation mechanisms in reconstituted systems.