Laser-plasma electron and ion accelerators attract great interest for a wide range of applications thanks to the size, cost and repetition rate of the high-intensity lasers, and to the unique characteristics of the delivered particle beams. The high-impact applications include the cancer radiotherapy, imaging with X-ray contrast techniques for early cancer detection, materials characterisation, radiation-driven chemistry, border-security through the detection of dangerous substances, and in a longer term applications in high-energy particle physics. In the medical context, in addition to the treatment applications, we study how biological processes develop in cells under the stress of ionising radiation, in particular, the cellular response to the high dose (Flash effect) or Fast Fractionation (FF effect), and how these approaches can be beneficial to improve cancer treatment.

Simulation of isodose distribution of prostate cancer treated by 7 VHEE beams