Available Positions

Adult stem cells are key player in the regeneration of their corresponding tissue, and in the intestine these cells are located in the bottom of the crypt, proliferate every ~24h and have the ability to differentiate to all epithelial lineages including enterocytes, goblet, Paneth, enteroendocrine, tuft and microfold cells. These cells have multiple tasks in nutrient absorbing, mucus secretion, antimicrobial agents production, hormone secretion and cytokines production. Our group is interested in finding immunological properties of adult stem cells that may be involve in skewing differentiation patterns, altering communication with the microenvironment and dictating tissue response to various tissue stresses.

The Biton's group is looking for motivated people from all levels with experience in computer sciences/mathematics/statistics to join a vibrating tissue system biology group aiming to understand the gut mysteries utilizing genetics and genomics to uncover key pathological principles of complex genetic diseases such as inflammatory bowel diseases (IBD).

The Biton lab at the Weizmann Institute of Science is seeking a highly

motivated experimental or computational Post-doc fellow to join our laboratory investigating

epithelial-immune interactions in the gut.

The position will include designing and conducting experiments to elucidate mechanisms of epithelial-

immune crosstalk in the intestine

- Analyze and interpret complex datasets from multi-omics approaches,

including single-cell sequencing and proteomics

- Develop computational models of epithelial-immune interactions

- Collaborate with wet lab scientists to validate computational predictions

experimentally

- Present research findings at team meetings, conferences, and in peer-

reviewed publications

- Mentor junior researchers and contribute to grant writing efforts

## Qualifications:

- Ph.D. in Immunology, Computational Biology, or a related field

- Strong background in mucosal immunology, with a focus on intestinal

biology

- Expertise in bioinformatics and data analysis, particularly for high-

dimensional datasets

- Proficiency in programming languages such as R or Python

- Experience with single-cell sequencing technologies and analysis

pipelines

- Familiarity with intestinal organoid culture techniques is desirable

- Excellent communication and collaboration skills