Research

Epithelial Stem Cell Biology

Intestinal stem cells (ISCs) are well-characterized adult stem cells. However, their contribution to mucosal immunity is less appreciated. We are now exploring the role of ISCs in innate and adaptive immune responses, which maintain gut homeostasis and, when disrupted, lead to a wide array of diseases. Our toolbox includes in vitro gut organoids, spheroids, and monolayers, as well as in vivo mouse models.

Exploring Immune-Epithelial Interactions

The gut tissue is rich in immune cells that are in close contact with a wide range of antigens derived from nutrients and the microbiota, making the gut the primary source of non-self antigens in the body. We would like to investigate the role of epithelial cells in instructing the gut mucosal immune system.

Illuminating Celiac Disease and Intestinal Bowel Diseases Pathogenesis.

Dysfunction of the epithelial barrier may lead to Celiac disease (CD) or Inflammatory Bowel Diseases (IBD), commonly separated into two major diseases: Crohn's disease and Ulcerative colitis. We are interested in understanding disease mechanisms underlying CD and IBD, with an emphasis on uncovering the contributions of self and non-self antigens, many of which have unknown function.