Publications

2024

Mitochondrial structural alterations in fibromyalgia: a pilot electron microscopy study

Israel L., Furer V., Levin-Zaidman S., Dezorella N., Brontvein O., Ablin J. N. & Gross A. (2024) Clinical and Experimental Rheumatology. 42, 6, p. 1215-1223

A BID-MTCH2 love story: Energizing mitochondria until apoptosis do them part?

Gross A. (2024) Bioenergetics Communications. 2024, 2024.1.

MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion

Goldman A., Mullokandov M., Zaltsman Y., Regev L., Levin-Zaidman S. & Gross A. (2024) EMBO Reports. 25, 1, p. 45-67

2023

High-energy demand and nutrient exhaustion in MTCH2 knockout cells

Chourasia S., Petucci C., Wang H., Han X., Sivan E., Brandis A., Mehlman T., Malitsky S., Itkin M., Rotkopf R., Regev L., Zaltsman Y. & Gross A. (2023) BioRxiv.

2021

Kynurenic acid- a key metabolite protecting the heart from an ischemic damage

Entin-Meer M., Bigelman E. B., Pasmanik-Chor M. P. C., Dassa B. D., Gross A. G., Itkin M. I., Malitsky S. M., Dorot O. D., Pichinuk E. P., Dezorell N. M. & Keren G. K. (2021) European Heart Journal. 42, Supplement_1, ehab724.32.

2020

Peripheral blood cell mitochondrial dysfunction in myelodysplastic syndrome can be improved by a combination of coenzyme Q10 and carnitine

Filanovsky K., Haran M., Mirkin V., Braester A., Shevetz O., Stanevsky A., Sigler E., Votinov E., Zaltsman-Amir Y., Berrebi A., Gross A. & Shvidel L. (2020) Mediterranean Journal of Hematology and Infectious Diseases. 12, 1, e2020072.

Perpheral blood cell mitochondrial dysfunction in myelodysplastic syndrome can be improved by a combination of coenzyme Q10 and carnitine: Blood cell mitochondrial dysfunction in myelodysplastic syndrome

Filanovsky K., Haran M., Mirkin V., Braester A., Shevetz O., Stanevsky A., Sigler E., Votinov E., Zalzman-Amir Y., Berrebi A., Gross A. & Shvidel L. (2020) Mediterranean Journal of Hematology and Infectious Diseases. 12, 1, p. e2020072-

Mitochondrial carrier homolog 2 is necessary for AML survival

Khan D. H., Mullokandov M., Wu Y., Voisin V., Gronda M. V., Hurren R., Wang X., MacLean N., Jeyaraju D. V., Jitkova Y., Xu G. W., Laister R. C., Seneviratne A., Blatman Z., Ketala T., Bader G. D., Marhon S. A., Carvalho D. D. D., Minden M. D., Gross A. & Schimmer A. D. (2020) Blood. 136, 1, p. 81-92

2019

Mitochondrial plasticity in cell fate regulation

Bahat A. & Gross A. (2019) Journal of Biological Chemistry. 294, 38, p. 13852-13863

The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids

Seneviratne A. K., Xu M., Henao J. J. A., Fajardo V. A., Hao Z., Voisin V., Xu G. W., Hurren R., Kim S., MacLean N., Wang X., Gronda M., Jeyaraju D., Jitkova Y., Ketela T., Mullokandov M., Sharon D., Thomas G., Chouinard-Watkins R., Hawley J. R., Schafer C., Yau H. L., Khuchua Z., Arnan A., Al-awar R., Gross A., Claypoo S. M., Bazinet R., Lupien M., Chan S., De Carvalho D. D., Minden M. D., Bader G. D., Stark K. D., LeBlanc P. & Schimmer A. D. (2019) Cell Stem Cell. 24, 4, p. 621-636

2018

MTCH2-mediated mitochondrial fusion drives exit from naive pluripotency in embryonic stem cells

Bahat A., Goldman A., Zaltsman Y., Khan D. H., Halperin C., Amzallag E., Krupalnik V., Mullokandov M., Silberman A., Erez A., Schimmer A. D., Hanna J. H. & Gross A. (2018) Nature Communications. 9, 5132.

Learning Deficits in Adult Mitochondria Carrier Homolog 2 Forebrain Knockout Mouse

Aloni E., Ruggiero A., Gross A. & Segal M. (2018) Neuroscience. 394, p. 156-163

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Galluzzi L., Vitale I., Aaronson S. A., Abrams J. M., Adam D., Agostinis P., Alnemri E. S., Altucci L., Amelio I., Andrews D. W., Annicchiarico-Petruzzelli M., Antonov A. V., Arama E., Baehrecke E. H., Barlev N. A., Bazan N. G., Bernassola F., Bertrand M. J. M., Bianchi K., Blagosklonny M. V., Blomgren K., Borner C., Boya P., Brenner C., Campanella M., Candi E., Carmona-Gutierrez D., Cecconi F., Chan F. K. -., Chandel N. S., Cheng E. H., Chipuk J. E., Cidlowski J. A., Ciechanover A., Cohen G. M., Conrad M., Cubillos-Ruiz J. R., Czabotar P. E., D'Angiolella V., Dawson T. M., Dawson V. L., De laurenzi V., De Maria R., Debatin K., DeBerardinis R. J., Deshmukh M., Gross A., Kimchi A., Oren M. & Wallach D. (2018) Cell Death and Differentiation. 25, 3, p. 486-541

Obesity, diabetes and zinc: A workshop promoting knowledge and collaboration between the UK and Israel, november 28-30, 2016-Israel

Jenkins A., Lengyel I., Rutter G. A., Lowe N., Shai I., Tirosh A., Petro T., Khamaisi M., Andrews S., Zmora N., Gross A., Maret W., Lewis E. C. & Moran A. (2018) Journal of Trace Elements in Medicine and Biology. 49, p. 79-85

2017

Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function

Item F., Wueest S., Lemos V., Stein S., Lucchini F. C., Denzler R., Fisser M. C., Challa T. D., Pirinen E., Kim Y., Hemmi S., Gulbins E., Gross A., O'Reilly L. A., Stoffel M., Auwerx J. & Konrad D. (2017) Nature Communications. 8, 1, 480.

Non-apoptotic functions of BCL-2 family proteins

Gross A. & Katz S. G. (2017) Cell Death and Differentiation. 24, 8, p. 1348-1358

The IFN-1 > BID > ROS pathway: Linking DNA damage with HSPC malfunction

Gross A., Tasdogan A. & Fehling H. J. (2017) Cell Cycle. 16, 9, p. 819-820

Loss of forebrain MTCH2 decreases mitochondria motility and calcium handling and impairs hippocampal-dependent cognitive functions

Ruggiero A., Aloni E., Korkotian E., Zaltsman Y., Oni-Biton E., Kuperman Y., Tsoory M., Shachnai L., Levin-Zaidman S., Brenner O., Segal M. & Gross A. (2017) Scientific Reports. 7, 44401.

MTCH2 is a Conserved Regulator of Lipid Homeostasis

Rottiers V., Francisco A., Platov M., Zaltsman Y., Ruggiero A., Lee S. S., Gross A. & Libert S. (2017) Obesity. 25, 3, p. 616-625

2016

BCL-2 family proteins as regulators of mitochondria metabolism

Gross A. (2016) Biochimica et Biophysica Acta - Bioenergetics. 1857, 8, p. 1243-1246

Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity

Buzaglo-Azriel L., Kuperman Y., Tsoory M., Zaltsman Y., Shachnai L., Levin-Zaidman S., Bassat E., Michailovici I., Sarver A., Tzahor E., Haran M., Vernochet C. & Gross A. (2016) Cell Reports. 14, 7, p. 1602-1610

The ATM-BID pathway plays a critical role in the DNA damage response by regulating mitochondria metabolism

Gross A., Zaltsman Y. & Maryanovich M. (2016) Cell Death and Differentiation. 23, 1, p. 182

2015

The BH3-only protein BID impairs the p38-mediated stress response and promotes hepatocarcinogenesis during chronic liver injury in mice

Orlik J., Schüngel S., Buitrago-Molina L. E., Marhenke S., Geffers R., Endig J., Lobschat K., Rössler S., Goeppert B., Manns M. P., Gross A. & Vogel A. (2015) Hepatology. 62, 3, p. 816-828

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

Maryanovich M., Zaltsman Y., Ruggiero A., Goldman A., Shachnai L., Porat Z., Golan K. & Gross A. (2015) Nature Communications. 6, 7901.

2014

Distribution and Apoptotic Function of Outer Membrane Proteins Depend on Mitochondrial Fusion

Weaver D., Eisner V., Liu X., Várnai P., Hunyady L., Gross A. & Hajnóczky G. (2014) Molecular Cell. 54, 5, p. 870-878

2013

Rejuvenating bi(d)ology

Zinkel S. S., Yin X. M. & Gross A. (2013) Oncogene. 32, 27, p. 3213-3219

TBid undergoes multiple conformational changes at the membrane required for bax activation

Shamas-Din A., Bindner S., Zhu W., Zaltsman Y., Campbell C., Gross A., Leber B., Andrews D. W. & Fradin C. (2013) Journal of Biological Chemistry. 288, 30, p. 22111-22127

A ROS rheostat for cell fate regulation

Maryanovich M. & Gross A. (2013) Trends in Cell Biology. 23, 3, p. 129-134

2012

Mitochondrial carrier homolog 2 (MTCH2): The recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis

Robinson A. J., Kunji E. R. & Gross A. (2012) Experimental Cell Research. 318, 11, p. 1316-1323

The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells

Maryanovich M., Oberkovitz G., Niv H., Vorobiyov L., Zaltsman Y., Brenner O., Jung S. & Gross A. (2012) Nature Cell Biology. 14, 5, p. 535-541

Molecular basis of the interaction between proapoptotic truncated BID (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) protein: Key players in mitochondrial death pathway

Katz C., Zaltsman-Amir Y., Mostizky Y., Kollet N., Gross A. & Friedler A. (2012) Journal of Biological Chemistry. 287, 18, p. 15016-15023

BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation

Cabon L., Galán-Malo P., Bouharrour A., Delavallée L., Brunelle-Navas M. N., Lorenzo H. K., Gross A. & Susin S. A. (2012) Cell Death and Differentiation. 19, 2, p. 245-256

2011

A yeast BH3-only protein for the rescue

Gross A. (2011) Cell Death and Differentiation. 18, 10, p. 1543-1544

Utilizing mitochondrial events as biomarkers for imaging apoptosis

Yivgi-Ohana N., Eifer M., Addadi Y., Neeman M. & Gross A. (2011) Cell Death & Disease. 2, 6, e166.

2010

Aven-uing between nuclear export and cell cycle arrest

Gross A. (2010) Cell Cycle. 9, 20, p. 4043-4051

M(a)TCH-ing up mitochondrial apoptosis

Gross A. (2010) Cell Cycle. 9, 15, p. 2925-2926

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

Zaltsman Y., Shachnai L., Yivgi Ohana O. N., Schwarz M., Maryanovich M., Houtkooper R. H., Vaz F. M., De Leonardis L. F., Fiermonte G., Palmieri F., Gillissen B., Daniel P. T., Jimenez E., Walsh S., Koehler C. M., Roy S. S., Walter L., Hajnoczky G. & Gross A. (2010) Nature Cell Biology. 12, 6, p. 553-562

2009

The Strength of the Fas Ligand Signal Determines Whether Hepatocytes Act as Type 1 or Type 2 Cells in Murine Livers

Schuengel S., Buitrago-Molina L. E., Nalapareddy P. D., Lebofsky M., Manns M. P., Jaeschke H., Gross A. & Vogel A. (2009) Hepatology. 50, 5, p. 1558-1566

Programmed necrotic cell death induced by complement involves a bid-dependent pathway

Ziporen L., Donin N., Shmushkovich T., Gross A. & Fishelson Z. (2009) Journal of Immunology. 182, 1, p. 515-521

2008

A new Aven-ue to DNA-damage checkpoints

Gross A. (2008) Trends in Biochemical Sciences. 33, 11, p. 514-516

2007

Nucleocytoplasmic shuttling of BID is involved in regulating its activities in the DNA-damage response

Oberkovitz G., Regev L. & Gross A. (2007) Cell Death and Differentiation. 14, 9, p. 1628-1634

Bid Plays a Role in the DNA Damage Response

Zinkel S. S., Hurov K. E. & Gross A. (2007) Cell. 130, 1, p. 9-10

Mitochondrial carriers and pores: Key regulators of the mitochondrial apoptotic program?

Schwarz M., Andrade-Navarro M. A. & Gross A. (2007) Apoptosis. 12, 5, p. 869-876

Luteinizing hormone-induced caspase activation in rat preovulatory follicles is coupled to mitochondrial steroidogenesis

Yacobi K., Tsafriri A. & Gross A. (2007) Endocrinology. 148, 4, p. 1717-1726

Full Length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons

König H. G., Rehm M., Gudorf D., Krajewski S., Gross A., Ward M. W. & Prehn J. H. (2007) BMC Cell Biology. 8, 7.

2006

BCL2 family in DNA damage and cell cycle control

Zinkel S., Gross A. & Yang E. (2006) Cell Death and Differentiation. 13, 8, p. 1351-1359

BID as a double agent in cell life and death

Gross A. (2006) Cell Cycle. 5, 6, p. 582-584

2005

A role for proapoptotic BID in the DNA-damage response

Zinkel S., Hurov K., Ong C., Abtahl F., Gross A. & Korsmeyer S. (2005) Cell. 122, 4, p. 579-591

Proapoptotic BID is an ATM effector in the DNA-damage response

Kamer I., Sarig R., Zaltsman Y., Niv H., Oberkovitz G., Regev L., Haimovich G., Lerenthal Y., Marcellus R. C. & Gross A. (2005) Cell. 122, 4, p. 593-603

Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha

Grinberg M., Schwarz M., Zaltsman Y., Eini T., Niv H., Pietrokovski S. & Gross A. (2005) Molecular and Cellular Biology. 25, 11, p. 4579-4590

Mitochondrial carrier homolog 2: A clue to cracking the BCL-2 family riddle?

Gross A. (2005) Journal of Bioenergetics and Biomembranes. 37, 3, p. 113-119

2004

Gonadotropins enhance caspase-3 and -7 activity and apoptosis in the theca-interstitial cells of rat preovulatory follicles in culture

Yacobi K., Wojtowicz A., Tsafriri A. & Gross A. (2004) Endocrinology. 145, 4, p. 1943-1951

2003

BID-D59A is a potent inducer of apoptosis in primary embryonic fibroblasts

Sarig R., Zaltsman Y., Marcellus R. C., Flavell R., Mak T. W. & Gross A. (2003) Journal of Biological Chemistry. 278, 12, p. 10707-10715

2002

tBID homooligomerizes in the mitochondrial membrane to induce apoptosis

Grinberg M., Sarig R., Zaltsman-Amir Y., Frumkin D., Grammatikakis N., Reuveny E. & Gross A. (2002) Journal of Biological Chemistry. 277, 14, p. 12237-12245

2001

BCL-2 proteins: Regulators of the mitochondrial apoptotic program

Gross A. (2001) IUBMB Life. 52, 3-5, p. 231-236

2000

Biochemical and genetic analysis of the mitochondrial response of yeast to BAX and BCL-X(L)

Gross A., Pilcher K., Blachly-Dyson E., Basso E., Jockel J., Bassik M. C., Korsmeyer S. J. & Forte M. (2000) Molecular and Cellular Biology. 20, 9, p. 3125-3136