Mechanisms of leukocyte migration across distinct blood vessels during infections using genetically manipulated immune competent mice and state of the art imaging approaches. Imaging cancer cell crossing of blood vessels during metastatic processes.

Developing experimental and computational approaches for multiplexed imaging of clinical specimens to uncover tumor-immune interactions

Proteomic analysis of cancer heterogeneity to elucidate disease progression mechanisms and resistance to therapy

We study how antibodies are generated in response to invading pathogens in mouse models, infected subjects and cancer patients. We use this information to produce novel antibodies for immunotherapy.

We aim to develop novel translational strategies that will improve immunity against cancer, and to optimize the potency of currently available antibody based immunotherapies