Dr. Rina Rosenzweig

Our lab studies molecular machines in our cells, called chaperones, that can reverse the formation of toxic protein aggregates and amyloid fibers linked to a host of debilitating conditions, such as ALS, and Parkinson’s, Alzheimer's, and Huntington's diseases. We use a combination of advanced NMR (magnetic resonance) techniques and biochemical and biophysical functional assays to obtain a structural and mechanistic understanding of how these chaperones work, and the conformational changes they impose upon their clients to do so. Through this research we aim to identify why, in certain cases, chaperones fail in their task - giving rise to disease.