Decipher expression of molecular pathways and their function in cells, disease models and samples from patients.

Host-microbiome interactions in health and disease

Disulfide bonding in the folding, assembly, and regulation of proteins and protein complexes

We study why we age and how senescent cells impact aging, age-related diseases and cancer

Our lab aims to reveal the fundamental mechanisms governing chaperone activity in health and disease by applying a unique combination of advanced NMR methodologies with functional assays.

We identify systemic metabolic changes within the host that accompany or cause cancer

We study epigenetic events that contribute to cancer by applying innovative single-molecule technologies

Chromosome Catastrophes in Cancer

Characterization of the functions and mechanisms of long noncoding RNAs and of nuclear RNA export

Our lab is a major driver in developing and applying cutting edge single-cell genomics technologies and advanced computational approaches. We apply these novel tools in animal models and human patients to uncover immune regulatory mechanisms and pathways

We aim to develop novel translational strategies that will improve immunity against cancer, and to optimize the potency of currently available antibody based immunotherapies

Investigating how transcription and translation control the cellular response to environmental stimuli

Developing experimental and computational approaches for multiplexed imaging of clinical specimens to uncover tumor-immune interactions

Proteomic analysis of cancer heterogeneity to elucidate disease progression mechanisms and resistance to therapy

Proteostasis control in cancer and immune regulation

Functional genomics and transcriptomics in mouse models and humans

We develop algorithms and utilize single cell genomics for studying the organization and function of immune cells in a tissue

We use computers, chemistry and biology to design covalent ligands for interesting proteins, to understand biology and discovery drugs

We study how antibodies are generated in response to invading pathogens in mouse models, infected subjects and cancer patients. We use this information to produce novel antibodies for immunotherapy.