Dr. Ofer Shoshani
Chromosome abnormalities play an important role in cancer. Recent DNA sequencing efforts revealed the extent of cancer genome complexities. Our work identified how such abnormalities can drive cancer, and lead to therapy resistance.
We aim to uncover molecular mechanisms leading to catastrophic genomic events by developing chromosome manipulation approaches. This will help better understanding cancer evolution and drug resistance formation. Ultimately, we aim to identify vulnerabilities of cancer cells, specifically related to the role of DNA repair in initiating and maintaining chromosome abnormalities, with the intention of developing novel therapies that would prevent resistance formation.