Studying cell-cell communication mechanisms of malaria parasites within a population and with their hosts

Genetically engineered reporters for MRI

We study morphogenesis, cell biology and function of hypothalamic neurons, which regulate appetite, stress and social behavior

Investigating how adaptive variation arises (as opposed to being selected) and testing predictions of a theory of individual-specific adaptation that complements natural selection by explaining adaptation on every timescale and level of organization

Membrane protein folding and misfolding in health and disease

The goal of our research is to understand how pancreatic beta cells perform their unique functions

How diverse posttranscriptional modifications regulate the fate of mRNA

Drug resistance in cancer, effects that intra-tumor bacteria on cancer biology and drug resistance, ex vivo organ culture for the prediction of drug response

We study interactions between peripheral circadian clocks and exercise physiology, hypoxia signaling and metabolic pathways

An integrative approach for the exploration of melanoma genetic and immunological interactions

Genomic & state-dependent regulation of neural circuit plasticity

We study the mitochondria, and are especially passionate about their most ancient and conserved pathway- iron-sulfur cluster biosynthesis

Disulfide bonding in the folding, assembly, and regulation of proteins and protein complexes

Health effects of air polution, transport of bacteria and fungi in the atmosphere

Our studies proceed along three major lines: (1) Microbial population dynamics under stress, (2) Understanding drought resistance and engineering drought-resistant nutritious plants (3) The plant microbiome and its dynamics

Death without caspases and caspases without death in development

Proprioception and the the musculoskeletal system in development and disease

Chromosome Catastrophes in Cancer

Intracellular and intercellular trafficking of mRNA and its role in protein localization and cell physiology

Understanding epithelial, stem and immune cell interactions in the gut

Studying how human organs acquire their shape by developing 3D stem-cell systems and applying concepts from soft-matter physics

Biophysics, soft matter, active matter

We study how osteoclasts, the only cells in our body that can degrade bone, are formed and how they function, both in health and in disease

We use computers, chemistry and biology to design covalent ligands for interesting proteins, to understand biology and discovery drugs

Interactions between bacteria and the viruses that infect them

Mechanisms of axon growth, destruction and refinement during developmental neuronal remodeling

Multi modal molecular imaging of regulatory checkpoints in vascular remodeling in reproduction

From Single cells to Microbial Collectives

Human evolution and disease

We study the structure, function and evolution of systems that regulate gene expression, with emphasis on translation

Functional genomics and transcriptomics in mouse models and humans

Combine molecular biology, biochemical and advanced microscopy techniques to study myelinating glial cells

How human RNA viruses interact with their host cells and transform them into viral factories

We are interested to learn basic principles dictating specificity of proteinprotein interactions and how this relates to cell signaling

The synaptic basis for sexual dimorphism in the nervous system

We are interested in deciphering questions spanning from molecular to behavioral levels

The role of mitochondria in health and disease

Illuminating antigen presenters and their cross-talk with T cells to execute inflammatory and peaceful immune responses.

We investigate fundamental principles of mutagenesis and gene expression by high-throughput methods

We use model systems, both in vitro and in vivo, generate novel therapies and apply transcriptomics, along with proteomics and metabolic analyses.

Biological circuits: design, function and evolution • Regulatory genome: transcription, replication and the chromatin as a communication platform • Developmental patterning: morphogen gradients, scaling, robustness

Our group brings the tools of systems biology to bear on the grand challenges of sustainability

Decipher expression of molecular pathways and their function in cells, disease models and samples from patients.