Dr. Ariel Afek

To understand and treat genetic diseases, we need to decipher, at the molecular level, the biochemical processes that drive them; processes such as gene expression, replication, and DNA damage repair.

Our goal is to obtain a deep molecular understanding of protein-DNA interactions involved in these fundamental processes, as well as their roles in physiology, disease, and evolution.

To accomplish this, we are developing and using cutting-edge approaches to manipulate DNA molecules in high throughput and to introduce chemical and mechanical DNA perturbations that frequently occur in the human genome.

We believe in a multidisciplinary view that combines various experimental and computational approaches.