Organ growth, regeneration and aging: A focus on the vascular system.

The interplay between viruses and their hosts

We study how antibodies are generated in response to invading pathogens in mouse models, infected subjects and cancer patients. We use this information to produce novel antibodies for immunotherapy.

Biological circuits: design, function and evolution • Regulatory genome: transcription, replication and the chromatin as a communication platform • Developmental patterning: morphogen gradients, scaling, robustness

We investigate fundamental principles of mutagenesis and gene expression by high-throughput methods

Developing experimental and computational approaches for multiplexed imaging of clinical specimens to uncover tumor-immune interactions

The role of cellular mechanisms, signaling and metabolic crosstalk in mediating microbial interaction (host-virus, host-bacteria, predator-prey) in the marine environment

Chromosome Catastrophes in Cancer

Human evolution and disease

We develop algorithms for enzyme and antibody design and verify them using high-throughput experiments.

Host-microbiome interactions in health and disease

Functional genomics and transcriptomics in mouse models and humans

We study the tumor microenvironment, and how it is transcriptionally rewired by stress to promote cancer

Characterization of the functions and mechanisms of long noncoding RNAs and of nuclear RNA export