Prof. Neta Regev-Rudzki
AT THE MOLECUAR FRONTIERS OF CELL-CELL COMMUNICATION IN PARASITOLOGY.
Malaria, caused by Plasmodium falciparum, is the most devastating parasitic disease, killing up to a half a million people each year. We have previously showed that malaria parasites can communicate between them using secreted Extracellular Vesicles (EVs). EVs capable of delivering cargo of proteins, lipids and nucleic acids by fusing with target distal cells, thus providing a secure and efficient mode for signal delivery. Little is currently known about the precise mechanisms of parasite-derived EV cargo delivery and function. With malaria continuing to be a major global disease, advances toward understanding the basic biology of Plasmodium remain essential.