Prof. Orly Reiner

We study the process of embryonic brain development, and what goes awry during disease conditions. In the developing brain there is a relative change in the type of neuronal stem cells that are born; and neurons born in one position have to reach their final destination by active cell migration. These highly dynamic processes are regulated via the concerted action of multiple gene products. Through interdisciplinary approaches, combining molecular, biochemical, in vivo, ex vivo, and in vitro studies with mouse and human brain organoid models, we examine a wide range of human developmental brain malformations and diseases.