Prof. Schraga Schwartz

RNA is modified by >100 chemical modifications. These modifications are often highly ubiquitous, conserved and dynamically regulated in mRNA, imposing a unique and uncharacterized regulatory code. Our lab aims to crack this code, and understand how modifications on mRNA direct gene expression programs and cell state decisions. We moreover seek to explore how chemical modifications can be exploited for biotechnological and therapeutic applications. Our lab bridges experimental and computational aspects of biological research, combining genomic, genetic and biochemical approaches with tailored computational ones.