We use embryo-like structures grown from stem cells to uncover how a single cell becomes a complex organism. By combining bioengineering, high-throughput screening, and computational analysis, we explore the signals and forces that shape early development.
Engineering reproducible embryo models to study how life begins
In our lab, we use stem-cell–derived embryo models, such as embryoid bodies (EBs) and gastruloids, to explore how a single cell develops into a complex organism. Our experiments combine single-cell genomics, epigenomic profiling, bioengineering, and advanced microscopy to study how cells self-organize, make fate decisions, and coordinate during early development.
A key challenge with current embryo models is variability in shape and differentiation. We aim to develop reproducible, controllable in vitro systems that better mimic mouse and human embryogenesis. To achieve this, we perform high-throughput screens of biochemical and biomechanical cues, track developmental trajectories with live imaging, and integrate the results with computational analysis.
Joining this research offers hands-on training in stem cell culture, organoid/gastruloid systems, hydrogel encapsulation, imaging, and molecular profiling, while working in close collaboration with computational scientists. This is an exciting opportunity for students interested in bridging wet-lab experimentation with quantitative analysis to uncover the mechanisms that make embryonic development both complex and robust