Metacell 2
A recursive divide and conquer algorithm allowing efficient decomposition of scRNA-seq datasets of any size.
Research
DNA methylation landscapes of 1538 breast cancers
Profiling the DNA methylation landscape of 1538 breast cancers.
Personalized lab test models
Personalized lab test models quantify disease potentials in healthy individuals.
Understanding cell fate decisions in early mammalian development
A time-resolved, high-resolution model charts differentiation dynamics during mouse gastrulation and reveals that for most lineages, cell fates arise from multi-furcation events rather than classical tree-like bifurcation (in collaboration with the Stelzer group)
Mechanisms of plasticity and commitment in plants
Mechanisms of plasticity and commitment in plants (in collaboration with Y. Eshed group)
Cross species manifold alignment
Time-Aligned Hourglass Gastrulation Models in Rabbit and Mouse
Understanding the role of DNA methylation during development
DNA methyltransferases 3A and 3B target specific sequences during mouse gastrulation
Dissecting cell-intrinsic and extrinsic effects of DNA demethylation during gastrulation
Understanding the embryonic phenotype of TET loss (with the Stelzer lab)
Modeling healthy aging
Understanding human longevity using EHR data