Research

Interpretable Computational Engine for Quantitative Regression of Enhancer ATAC Motifs, in short: IQ

IceQream: Interpretable ATAC regression

IceQream (IQ) is a transparent, robust tool for predicting chromatin accessibility from DNA sequences using mechanistic models of transcription factor binding. Unlike black-box methods, IQ offers interpretable insights into gene regulation and cell state transitions across single-cell data.

UMAP of the MOCA dataset, analyzed by Metacell 2

Metacell 2

A recursive divide and conquer algorithm allowing efficient decomposition of scRNA-seq datasets of any size.