cell shedding into the lumen of E7.5 mouse embryo

Expanding the PCD network

A major focus of the lab has been to identify network interconnectivity, and to understand the significance of alternative death pathways. Of particular interest are nodes that have multi-modular functions that can be thought of as integration hubs that connect the various modules.

The PCD network

Harnessing the PCD network for disease treatment

We have harnessed our new insights into the PCD network to understand the etiology of disease and to design cell death-based therapies for diseases involving perturbations of the network, such as cancer and inflammation.