Publications
2021
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Harsh Maan, Jonathan Friedman and Ilana Kolodkin-Gal (2021) Resolving the conflict between antibiotic production and rapid growth by recognition of peptidoglycan of susceptible competitors BioarchivesPreprint
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Nir Salinas, Tatyana L. Povolotsky, Meytal Landau and Ilana Kolodkin-Gal (2021) Beyond Scaffolds: Emerging Roles of Functional Bacterial Amyloids in Gene Regulation, Toxicity and Immunomodulation Microbiology and Molecular Biology ReviewsIn press (Selected for the issue cover)
2020
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Nitai Steinberg*, Alona Keren-Paz*, Qihui Hou, Shany Doron, Keren Yanuka-Golub, Tsviya Olender, Rotem Hadar, Rakeshkumar Jain, Jesus Cámara-Almirón,Sven van Teeffelen, Diego Romero and Ilana Kolodkin-Gal (2020) The extracellular matrix protein TasA is a developmental cue that maintains a motile subpopulation within Bacillus subtilis biofilms Science SignalingIn press (Selected for the issue cover)
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Qihui Hou, Alona Keren-Paz and Ilana Kolodkin-Gal (2020) Weaponizing Volatiles to Inhibit Competitor Biofilms from a Distance npj Biofilms and Microbiomes
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Qihui Hou and Ilana Kolodkin-Gal (2020) Harvesting the complex pathways of antibiotic production and resistance of soil bacilli for optimizing plant microbiome FEMS Microbiology Ecology
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Alona Keren-Paz, Malena Cohen-Cymberknoh, Dror Kolodkin-Gal, Iris Karunker, Simon Dersch, Sharon G. Wolf, Tsviya Olender, Elena Kartvelishvily, Sergey Kapishnikov, Peninnah Green-Zelinger, Michal Shteinberg, Gideon Zamir, Assaf Gal, Peter Graumann, Eitan Kerem and Ilana Kolodkin-Gal (2020) A novel calcium-concentrating compartment drives biofilm formation and persistent infections Preprint
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Tatyana L. Povolotsky, Alona Karen-Paz and Ilana Kolodkin-Gal (2020) Metabolic Microenvironments Drive Microbial Differentiation and Antibiotic Resistance Trends In GeneticsIn press
2019
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Hadas Ganin, Natalie Kemper, Sagit Meir, Ilana Rogachev, Shir Ely, Hassan Massalha, Aviad Mandaby, Abraham Shanzer, Michael M. Meijler, Sergey Malitsky, Asaph Aharoni, and Ilana Kolodkin-Gal (2019) Indole derivatives maintain the status quo between beneficial biofilms and their plant hosts Molecular Plant Microbe Interactions
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Alona Keren-Paz and Ilana Kolodkin-Gal (2019) A Brick in the Wall: Discovering a Novel Mineral Component of the Biofilm Extracellular Matrix New Biotechnology
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Tabitha Bucher, Alona Keren-Paz, Jean Hausser, Tsviya Olender, Eddie Cytryn and Ilana Kolodkin-Gal (2019) An active β-lactamase is a part of an orchestrated cell wall stress resistance network of Bacillus subtilis and related rhizosphere species Environmental Microbiology
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Ariel Ogran, Eliane Hadas Yardeni, Tabitha Bucher, Rakeshkumar Jain, Omri Gilhar, Alona Keren-Paz, and Ilana Kolodkin-Gal
(2019) The plant host induces antibiotic production in B. subtilis biofilms to increase their competitiveness Applied and Environmental Microbiology -
Keith Harris and Ilana Kolodkin-Gal (2019) Applying the Handicap Principle to Biofilms: Condition-Dependent Signalling in Bacillus Subtilis Microbial Communities Environmental Microbiology
2018
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Alona Keren-Paz, Vlad Brumfeld, Yaara Oppenheimer-Shaanan, and Ilana Kolodkin-Gal (2018) Micro-CT X-ray Imaging Exposes Structured Diffusion Barriers within Biofilms npj Biofilms and Microbiomes
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Eyal Rosen, I Kolodkin-Gal , Igor Tsesis (2018) Challenges in the Eradication of Enterococcus faecalis and its Implications on Health Current Oral Health Reports
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Tal Hassanov, Iris Karunker-Hazan, Nitai Steinberg, Ayelet Erez, and Ilana Kolodkin-Gal (2018) Novel antibiofilm chemotherapies target nitrogen from glutamate and glutamine Scientific Reports 8(1):7097
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Nitai Steinberg, Gili Rosenberg, Alona Keren-Paz, and Ilana Kolodkin-Gal (2018) Collective vortex-like movement of Bacillus subtilis facilitates the generation of floating biofilms Frontiers in Microbiology 9: 590
2017
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Lianet Noda-García,Maria-Luisa Romero, Liam Longo, Ilana Kolodkin-Gal , and Dan Tawfik (2017) Coevolution of transcriptional and protein regulation underlies the divergence of Bacilli glutamate dehydrogenases. Embo Reports 7:1139-1149
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Ayelet Erez and Ilana Kolodkin-Gal. (2017) From prokaryotes to cancer: glutamine flux in multicellular units. Trends in Metabolism and Endocrinology 9:637-644
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Martyn Dade-Robertson, Alona Keren-Paz, Meng Zhang and Ilana Kolodkin-Gal (2017) Architects of nature: growing buildings with bacterial biofilms. Microbial Biotechnology 5:1157-1163
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Ilana Kolodkin-Gal (2017) Beyond the wall: Can D-amino acids and small molecule inhibitors solely used to eliminate infection? Future Medicinal Chemistry 9:843-846
2016
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Yaara Oppenheimer-Shaanan, Odelia Sibony-Nevo, Zohar Bloom-Ackermann, Ronit Suissa, Nitai Steinberg, Elena Kartvelishvily, Vlad Brumfeld and Ilana Kolodkin-Gal. (2016) Spatio-temporal Assembly of Functional Mineral Scaffolds within Microbial Biofilms. npj Biofilms and Microbiomes
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Gili Rosenberg, Nitai Steinberg, Yaara Oppenheimer-Shaanan, Tsvia Olender, Shany Doron, Julius Ben-Ari, Alexandra Sirota-Madi, Zohar Bloom-Ackermann and Ilana Kolodkin-Gal. (2016) Not so simple, not so subtle: The interspecies competition between Bacillus simplex and Bacillus subtilis and its impact on the evolution of biofilms. npj Biofilms and Microbiomes
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Zohar Bloom-Ackermann, Nitai Steinberg, Gili Rosenberg, Yaara Oppenheimer-Shaanan, Dan Pollack, Shir Ely, Nimrod Storzi, Asaf Levy and Ilana Kolodkin-Gal. (2016) Toxin-Antitoxin systems eliminate defective cells and preserve symmetry in Bacillus subtilis biofilms. Environmental Microbiology 18:5032–5047
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Tabitha Bucher, Elena Kartvelishvily and Ilana Kolodkin-Gal. (2016) Methodologies to study Bacillus subtilis biofilms as models for characterizing small molecule biofilm inhibitors. The Journal of Visualized Experiments 116 doi:10.3791/54612
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Sathish Kumar, Ilana Kolodkin-Gal, Oliver Vesper, Nawsad Alam, Ora Schueler-Furman, Isabella Mol and Hanna Engelberg-Kulka. (2016) The Generation of Escherichia coli Quorum Sensing Peptide EDF: A Novel Multi-distinct Mechanism Regulated by Trans-translation. mBio 7(1):e02034-15
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Eyal Rosen, Igor Tsesis, Shlomo Elbahary, Nimrod Storzi and Ilana Kolodkin-Gal. (2016) Eradication of Enterococcus faecalis biofilms on human dentin. Fronties in Microbiology 7:2055
2015
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Tabitha Bucher, Yaara Oppenheimer-Shaanan , Alon Savidor, Zohar Bloom-Ackermann and Ilana Kolodkin-Gal. (2015) Disturbance of the bacterial cell wall specifically interferes with biofilm formation. Enviornmental Microbiology Reports 7: 990–1004
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Zohar Bloom-Ackermann, Hadas Ganin and Ilana Kolodkin-Gal. (2015) Quorum Sensing Cascades Governing Bacterial Multicellular Communities. IJCH 56: 302–309
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Nitai Steinberg and Ilana Kolodkin-Gal. (2015) The Matrix Reloaded: Probing the Extracellular Matrix Synchronizes Bacterial Communities. J Bacteriol. 197:2092-2103
2014
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Hadas Ganin, Eliane Hadas Yardeni, and Ilana Kolodkin-Gal. (2014) Biofilms: Maintenance, Development, and Disassembly of Bacterial Communities Are Determined by QS Cascades. A book chapter in "Quorum sensing Vs Quorum Quenching: A Battle with no end in sight" [Springer]
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Jotham Suez, Tal Korem, David Zeevi, Gili Zilberman-Schapira, Christoph A. Thaiss, Ori Maza, David Israeli, Niv Zmora, Shlomit Gilad, Adina Weinberger, Yael Kuperman, Alon Harmelin, Ilana Kolodkin-Gal, Hagit Shapiro, Zamir Halpern, Eran Segal and Eran Elinav. (2014) Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature 514:181–186
2013
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Ilana Kolodkin-Gal, Alexander KW Elsholz, Christine Muth, Peter R Girguis, Roberto Kolter, Richard Losick
(2013) Respiration control of multicellularity in Bacillus subtilis by a complex of the cytochrome chain with a membrane-embedded histidine kinase Genes and Development -
Jotham Suez , Tal Korem , David Zeevi , Gili Zilberman-Schapira , Christoph A Thaiss , Ori Maza ,David Israeli, Niv Zmora, Shlomit Gilad, Adina Weinberger, Yael Kuperman, Alon Harmelin, Ilana Kolodkin-Gal, Hagit Shapiro, Zamir Halpern, Eran Segal, Eran Elinav
(2013) Artificial Sweeteners Induce Glucose Intolerance by Altering the Gut Microbiota Nature -
Yaara Openheimer-Shaanan, Nitai Steinberg and Ilana Kolodkin-Gal. (2013) Small Molecules are Natural Triggers for biofilm Disassembly. Trends in Microbiology 21:594–601
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Sathish Kumar*, Ilana Kolodkin-Gal*, Hanna Engelberg-Kulka. (2013) Quorum Sensing Peptides Mediate Interspecies Bacterial Cell Death. mBio, 4(3):e00314-13*Equal contribution.
Additional Selected Publications
- Ilana Kolodkin-Gal*, S.M. Rubinstein*, Liraz Chai, Roberto Kolter, Richard Losick, David A, Weitz (2012) Osmotic pressure can regulate matrix gene expression in Bacillus subtilis. Mol Microb. 86:426-3. *Equal contribution.
- Anna L. McLoon *, Ilana Kolodkin-Gal *, S.M. Rubinstein, R. Kolter, R. Losick (2011) Spatial Regulation of Histidine Kinases Governing Biofilm Formation in Bacillus subtilis. J Bacteriol. 193:679-85. *Equal contribution
- Ilana Kolodkin-Gal, D. Romero, Shugeng Cao, J. Clardy, R. Kolter, R. Losick (2010) D-amino acids trigger biofilm disassembly. Science 328: 627-629.
- S. Amitai, Ilana Kolodkin-Gal, A. Sacher, H. Engelbeg-Kulka (2009) Escherichia coli MazF leads to simultaneous selective synthesis of both "death proteins" and "survival proteins". PLoS Genetics 5: e1000390.
- Ilana Kolodkin-Gal, B, Sat, A. Keshet, H. Engelberg- Kulka (2009) Communication Factor EDF and mazEF are Determinants in the Mode of Action of Antibiotics in Escherichia coli. PLoS Biology 6:e319.
- Ilana Kolodkin-Gal, R Hazan, A Gaathon, S/ Carmeli, H. Engelberg-Kulka (2007) A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli. Science 318:652-5.
- Ilana Kolodkin-Gal, H. Engelberg-Kulka (2006) Induction of Escherichia coli Chromosomal mazEF by stressful conditions causes an irreversible loss of viability. J.Bacteriol. 188:3420-3.
- H. Engelberg-Kulka, S. Amitai, Ilana Kolodkin-Gal, R. Hazan (2006) Bacterial programmed cell death and multicellular behavior in bacteria. PLoS Genet. 2:e135.
Patents
- Kolodkin-Gal I, Engelberg-Kulka H. Antibacterial peptides and methods of treating disease using same. Patent No. PCT/IL2008/000039.
- Kolodkin-Gal I, Engelberg-Kulka H. Identification of Bacillus subtilis and Pseudomonas aeriginosa peptides inducing bacterial cell death. Declaration of invention.
- Richard Losick, Jon Clardy, Roberto G. Kolter, Ilana Kolodkin, Diego Romero, and Shugeng Cao. D -amino acids as anti-biofilm agents. Provisional Patent Application No. 61/293/414
- Richard Losick, Jon Clardy, Roberto G. Kolter, Ilana Kolodkin, Liraz Chai, and Shugeng Cao. Norspermidine act as an antibiofilm agent. Preliminary Assessment of Patentability
- Jon Clardy, Thomas Boettcher, Ilana Kolodkin-Gal, Richard Losick. Methods and copositions for treating biofilms. Patent assignment