Enteroviruses dramatically remodel the architecture of their host cells. During infection, the morphology of multiple organelles is altered, and some organelles are destroyed. Moreover, enteroviruses induce the formation of new organelles that exist only in infected cells. All these fascinating changes are part of a viral master plan to transform host cells into virus manufactories. We investigate how enteroviruses remodel the structure and function of organelles, and how the remodeled organelles support virus replication. Uncovering the underlying mechanisms could lead to the development of new antiviral therapeutic strategies.