Research
No organism navigates life unscathed, and tissue damage is an inevitable part of existence. Injury triggers cellular responses critical for recovery and tissue function, while also eliciting pain through nociceptive neurons that detect noxios stimuli and signal the brain. Beyond the role of pain as an alarm mechanism that alters behavior to protect damaged tissues, pain-sensing neuronal circuitry also shapes tissue physiology and regeneration through pathways that remain poorly understood. Our research explores these pathways by levarging mouse genetics, RNA sequencing and a range of biological tools, aiming to reveal the role of sensory neuronal networks in regulating tissue function and repair.
Research page
Decoding communication between cutaneous nociceptors and skin-resident cells
Characterizing the molecular response of sensory neurons to tissue damage
Exploreing connections between ascending sensory pathways and tissue regeneration
