The Crown Photonics Center promotes the study of light and its applications. The Weizmann Institute is a global leader in basic photonics research. Photonics has given rise to the discovery of gamma rays, ultraviolet light, infrared light, microwaves, and radio waves, with applications ranging from biomedicine to homeland security, and including computing, medical diagnostics, imaging, on-chip data communication, and laser defense.

The Center for Experimental Physics fosters research in all areas of experimental physics, ranging from the most basic aspects of particle physics to experimental studies of basic material properties such as semiconductors and superconductors. Research also involves atomic, molecular, plasma and optical physics and interdisciplinary studies of the physics of biological systems.

The André Deloro Institute for Space and Optics Research explores the nature of the universe from the smallest sub-particle to the most distant galaxies. It brings together scientists investigating the nature of light and matter on the quantum scale of particle physics; planetary and space scientists working on an astronomical scale ranging from micro-meteors to giant gas planets to supernova explosions at the outer edges of the universe; and theoretical scientists who work on scales both vast and infinitesimal.