Milo Lab

Design Principles in Energy &
Carbon Metabolism

Research

We love to understand and explain the world using numbers as our sixth sense. Our group brings the tools of systems biology to bear on the grand challenges of sustainability. My lab members and I are passionate about trying to understand the cellular highways of energy and carbon transformations known as central carbon metabolism in quantitative terms. We employ a combination of computational and experimental synthetic biology tools.

Research page

Selected Publications

Electro-microbial production techno-economic viability and environmental implications

Lovat S. J., Ben-Nissan R., Milshtein E., Tzachor A., Flamholz A., Leger D., Noor E. & Milo R. (2025) Nature Biotechnology. 2231.

A systematic exploration of bacterial form I rubisco maximal carboxylation rates

de Pins B., Greenspoon L., Bar-On Y. M., Shamshoum M., Ben-Nissan R., Milshtein E., Davidi D., Sharon I., Mueller-Cajar O., Noor E. & Milo R. (2024) EMBO Journal. 43, 14, p. 3072-3083

Autotrophic growth of Escherichia coli is achieved by a small number of genetic changes

Ben Nissan R., Milshtein E., Pahl V., de Pins B., Jona G., Levi D., Yung H., Nir N., Ezra D., Gleizer S., Link H., Noor E. & Milo R. (2024) eLife. 12, RP88793.

The global biomass of wild mammals

Greenspoon L., Krieger E., Sender R., Rosenberg Y., Bar-On Y. M., Moran U., Antman T., Meiri S., Roll U., Noor E. & Milo R. (2023) Proceedings of the National Academy of Sciences - PNAS. 120, 10, e220489212.
All Publications