Available Positions

Discover new principles of protein organization in cells using a mixture of computational and experimental approaches. Keywords: protein structure, protein evolution, protein interactions, yeast genetics, structural systems biology

Rotation: 
2nd
3rd
Area: 
Chemistry
Life Sciences
Mathematics and Computer Science
Physics
Sunday, October 17, 2021

In a single yeast cell, the protein machinery is made of an estimated 50,000,000 protein molecules. Understanding how these proteins are organized in space and time with respect to each other to bring about life is a tremendous challenge central to biology, and at the core of our research.

In order to understand principles of protein organization inside cells, we use both in vivo and in silico approaches. These involve biochemistry, protein engineering, genetics, high-throughput screens, as well as in silico analyses of biological data - in particular of structural and network data.



You can check the web-site for more information: www.elevylab.org

Synthetic biology: Design of a protein chaperone

Rotation: 
1st
2nd
3rd
Area: 
Chemistry
Life Sciences
Mathematics and Computer Science
Physics
Sunday, October 17, 2021

The classic quote from Richard Feynman "What I cannot create I do not understand" best summarizes the motivation for this project, which goal is to design a chaperone based on a protein that is not itself a chaperone. This should reveal what properties are key to chaperones and thereby provide a proof that we understand how chaperones function.