Publications

2017

  • Sharon Grayer Wolf; Yael Mutsafi; Tali Dadosh; Tal Ilani; Zipora Lansky; Ben Horowitz; Sarah Rubin; Michael Elbaum; Deborah Fass (2017). 3D visualization of mitochondrial solid-phase calcium stores in whole cells.  eLife. 6.  Abstract

2016

  • Gad Armony; E Jacob; Toot Moran; Yishai Levin; Tevie Mehlman; Yehoshua Levy; Deborah Fass (2016). Cross-linking reveals laminin coiled-coil architecture.  Proceedings of the National Academy of Sciences of the United States of America. 113:(47)13384-13389.  Abstract
  • Le Zhang; Qing Cheng; Longjie Zhang; Yijun Wang; Gary F. Merrill; Tal Ilani; Deborah Fass; Elias S. J. Arner; Jinsong Zhang (2016). Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.  Free Radical Biology and Medicine. 99:426-435.  Abstract
  • Iris Grossman; Tal Ilani; Sarel-Jacob Fleishman; Deborah Fass (2016). Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma.  Protein engineering, design & selection : PEDS. 29:(4)135-47.  Abstract
  • Le Zhang, Qing Cheng, Longjie Zhang, Yijun Wang, Gary F. Merrill, Tal Ilani, Deborah Fass, Elias S.J. Arnér, Jinsong Zhang (2016). Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.  Free Radical Biology and Medicine. 99:426–435.

2015

  • Andriy Kryshtafovych; John Moult; Arnaud Baslé et al. (2015). Some of the most interesting CASP11 targets through the eyes of their authors.  Proteins.  Abstract [All authors]
  • David Kirchenbuechler; Yael Mutsafi; Smadar Levin-Zaidman; Ben Horowitz; Deborah Fass; Sharon G. Wolf; Michael Elbaum (2015). Cryo-STEM Tomography of Intact Vitrified Fibroblasts.  AIMS Biophysics. 2:(3)259-273.  Abstract
  • Toot Moran; Yair Gat; Deborah Fass (2015). Laminin L4 domain structure resembles adhesion modules in ephrin receptor and other transmembrane glycoproteins.  FEBS Journal. 282:(14)2746-2757.  Abstract
  • Iris Grossman; Aviram, Haim Yuval Aviram; Gad Armony; Amnon Horovitz; Hagen Hofmann; Gilad Haran; Deborah Fass (2015). Single-molecule spectroscopy exposes hidden states in an enzymatic electron relay.  Nature Communications. 6:8624.  Abstract

2014

  • Shai Biran; Yair Gat; Deborah Fass (2014). The Eps1p Protein Disulfide Isomerase Conserves Classic Thioredoxin Superfamily Amino Acid Motifs but Not Their Functional Geometries.  PLoS One. 9:(12)  Abstract
  • Deborah Fass; Katrin Rittinger (2014). Editorial overview: Multi-protein assemblies in signaling.  Current Opinion in Structural Biology. 29:VI-VIII.
  • Yair Gat; Alexandra Vardi-Kilshtain; Iris Grossman; Dan Thomas Major; Deborah Fass (2014). Enzyme structure captures four cysteines aligned for disulfide relay.  Protein Science. 23:(8)1102-1112.  Abstract
  • Andriy Kryshtafovych; John Moult; Patrick Bales et al. (2014). Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10.  Proteins-Structure Function And Bioinformatics. 82:26-42. [All authors]

2013

  • Iris Grossman; Assaf Alon; Tal Ilani; Deborah Fass (2013). An Inhibitory Antibody Blocks the First Step in the Dithiol/Disulfide Relay Mechanism of the Enzyme QSOX1.  Journal of Molecular Biology. 425:(22)4366-4378.  Abstract
  • Tal Ilani; Deborah Fass (2013). Now at the Met: Fine Art of Reversible Sulfoxidation.  Molecular Cell. 51:(3)281-282.  Abstract
  • Tal Ilani; Assaf Alon; Iris Grossman; Ben Horowitz; Elena Kartvelishvily; Sidney Cohen; Deborah Fass (2013). A Secreted Disulfide Catalyst Controls Extracellular Matrix Composition and Function.  Science. 341:(6141)74-76.  Abstract
  • Waisberg, Keren Limor Waisberg; Shifra Ben-Dor; Deborah Fass (2013). Diversification of Quiescin sulfhydryl oxidase in a preserved framework for redox relay.  BMC Evolutionary Biology. 13.  Abstract

2012

  • Waisberg, Keren Limor Waisberg; Assaf Alon; Tevie Mehlman; Deborah Fass (2012). Phylogenetics and enzymology of plant quiescin sulfhydryl oxidase.  FEBS Letters. 586:(23)4119-4125.  Abstract
  • Motti Hakim; Daria Ezerina; Assaf Alon; Ohad Vonshak; Deborah Fass (2012). Exploring ORFan Domains in Giant Viruses: Structure of Mimivirus Sulfhydryl Oxidase R596.  PLoS One. 7:(11)  Abstract
  • Assaf Alon; Iris Grossman; Yair Gat et al. (2012). The dynamic disulphide relay of quiescin sulphydryl oxidase.  Nature. 488:(7411)414-+.  Abstract [All authors]
  • Deborah Fass (2012). Disulfide Bonding in Protein Biophysics.  Annual Review Of Biophysics, Vol 41. 41:63-79.  Abstract

2011

  • Motti Hakim; Amitai Mandelbaum; Deborah Fass (2011). Structure of a Baculovirus Sulfhydryl Oxidase, a Highly Divergent Member of the Erv Flavoenzyme Family.  Journal of Virology. 85:(18)9406-9413.  Abstract
  • Frank DiMaio; Thomas C. Terwilliger; Randy J. Read et al. (2011). Improved molecular replacement by density- and energy-guided protein structure optimization.  Nature. 473:(7348)540-U149.  Abstract [All authors]

2010

  • Deborah Fass (2010). Hunting for Alternative Disulfide Bond Formation Pathways: Endoplasmic Reticulum Janitor Turns Professor and Teaches a Lesson.  Molecular Cell. 40:(5)685-686.  Abstract
  • Motti Hakim; Deborah Fass (2010). Cytosolic Disulfide Bond Formation in Cells Infected with Large Nucleocytoplasmic DNA Viruses.  Antioxidants & Redox Signaling. 13:(8)1261-1271.  Abstract
  • Nimrod Heldman; Ohad Vonshak; Carolyn S. Sevier; Elvira Vitu; Tevie Mehlman; Deborah Fass (2010). Steps in reductive activation of the disulfide-generating enzyme Ero1p.  Protein Science. 19:(10)1863-1876.  Abstract
  • Konstantin Kogan; Eric D. Spear; Chris A. Kaiser; Deborah Fass (2010). Structural Conservation of Components in the Amino Acid Sensing Branch of the TOR Pathway in Yeast and Mammals.  Journal of Molecular Biology. 402:(2)388-398.  Abstract
  • Jaime D. Blais; King-Tung Chin; Ester Zito; Yuhong Zhang; Nimrod Heldman; Heather P. Harding; Deborah Fass; Colin Thorpe; David Ron (2010). A Small Molecule Inhibitor of Endoplasmic Reticulum Oxidation 1 (ERO1) with Selectively Reversible Thiol Reactivity.  Journal of Biological Chemistry. 285:(27)20993-21003.  Abstract
  • Elvira Vitu; Sunghwan Kim; Carolyn S. Sevier et al. (2010). Oxidative Activity of Yeast Ero1p on Protein Disulfide Isomerase and Related Oxidoreductases of the Endoplasmic Reticulum.  Journal of Biological Chemistry. 285:(24)18155-18165.  Abstract [All authors]
  • Assaf Alon; Erin J. Heckler; Colin Thorpe; Deborah Fass (2010). QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains.  FEBS Letters. 584:(8)1521-1525.  Abstract

2009

  • Motti Hakim; Deborah Fass (2009). Dimer Interface Migration in a Viral Sulfhydryl Oxidase.  Journal of Molecular Biology. 391:(4)758-768.  Abstract
  • Elinor Erez; Deborah Fass; Eitan Bibi (2009). How intramembrane proteases bury hydrolytic reactions in the membrane.  Nature. 459:(7245)371-378.  Abstract
  • Ole Farver; Elvira Vitu; Scot Wherland; Deborah Fass; Israel Pecht (2009). Electron Transfer Reactivity of the Arabidopsis thaliana Sulfhydryl Oxidase AtErv1.  Journal of Biological Chemistry. 284:(4)2098-2105.  Abstract

2008

  • Elvira Vitu; Einav Gross; Harry M. Greenblaft; Carolyn S. Sevier; Chris A. Kaiser; Deborah Fass (2008). Yeast Mpd1p Reveals the Structural Diversity of the Protein Disulfide Isomerase Family.  Journal of Molecular Biology. 384:(3)631-640.  Abstract
  • Maya Bar; Yeliz Celik; Deborah Fass; Ido Braslavsky (2008). Interactions of beta-helical antifreeze protein mutants with ice.  Crystal Growth & Design. 8:(8)2954-2963.  Abstract
  • Deborah Fass (2008). The Erv family of sulfhydryl oxidases.  Biochimica Et Biophysica Acta-Molecular Cell Research. 1783:(4)557-566.  Abstract
  • Erin J. Heckler; Assaf Alon; Deborah Fass; Colin Thorpe (2008). Human quiescin-sulfhydryl oxidase, QSOX1: Probing internal redox steps by mutagenesis.  Biochemistry. 47:(17)4955-4963.  Abstract
  • Irina Portnaya; Einav Ben-Shoshan; Uri Cogan; Rafail Khalfin; Deborah Fass; Ory Ramon; Dganit Danino (2008). Self-assembly of bovine beta-casein below the isoelectric pH.  Journal of Agricultural and Food Chemistry. 56:(6)2192-2198.  Abstract
  • Maya Bar; Tali Scherf; Deborah Fass (2008). Two-dimensional surface display of functional groups on a beta-helical antifreeze protein scaffold.  Protein Engineering Design & Selection. 21:(2)107-114.  Abstract

2007

  • Elhanan Magidovich; Irit Orr; Deborah Fass; Uri Abdu; Ofer Yifrach (2007). Intrinsic disorder in the C-terminal domain of the Shaker voltage-activated K+ channel modulates its interaction with scaffold proteins.  Proceedings of the National Academy of Sciences of the United States of America. 104:(32)13022-13027.  Abstract
  • Carolyn S. Sevier; Hongjing Qu; Nimrod Heldman; Einav Gross; Deborah Fass; Chris A. Kaiser (2007). Modulation of cellular disulfide-bond formation and the ER redox environment by feedback-regulation of Ero1.  Cell. 129:(2)333-344.  Abstract
  • Daphna Frenkiel-Krispin; Sharon G. Wolf; Shira Albeck et al. (2007). Plant transformation by Agrobacterium tumefaciens - Modulation of single-stranded DNA-VirE2 complex assembly by VirE1.  Journal of Biological Chemistry. 282:(6)3458-3464.  Abstract [All authors]
  • Adam Ben-Shem; Deborah Fass; Eitan Bibi (2007). Structural basis for intramembrane proteolysis by rhomboid serine proteases.  Proceedings of the National Academy of Sciences of the United States of America. 104:(2)462-466.  Abstract

2006

  • Roy Sirkis; Jeffrey Gerst; Deborah Fass (2006). Ddi1, a eukaryotic protein with the retroviral protease fold.  Journal of Molecular Biology. 364:(3)376-387.  Abstract
  • Elvira Vitu; Moran Bentzur; Thomas Lisowsky; Chris A. Kaiser; Deborah Fass (2006). Gain of function in an ERV/ALR sulfhydryl oxidase by molecular engineering of the shuttle disulfide.  Journal of Molecular Biology. 362:(1)89-101.  Abstract
  • Maya Bar; Roy Bar-Ziv; Tali Scherf; Deborah Fass (2006). Efficient production of a folded and functional, highly disulfide-bonded beta-helix antifreeze protein in bacteria.  Protein Expression and Purification. 48:(2)243-252.  Abstract
  • Eilam Gross; CS Sevier; N Heldman; E Vitu; Moran Bentzur; CA Kaiser; C Thorpe; Deborah Fass (2006). Generating disulfides enzymatically: Reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p.  Proceedings of the National Academy of Sciences of the United States of America. 103:(2)299-304.  Abstract

2005

  • CS Sevier; H Kadokura; VC Tam; J Beckwith; Deborah Fass; CA Kaiser (2005). The prokaryotic enzyme DsbB may share key structural features with eukaryotic disulfide bond forming oxidoreductases.  Protein Science. 14:(6)1630-1642.  Abstract
  • F Forster; O Medalia; Nathan Zauberman; W Baumeister; Deborah Fass (2005). Retrovirus envelope protein complex structure in situ studied by cryo-electron tomography.  Proceedings of the National Academy of Sciences of the United States of America. 102:(13)4729-4734.  Abstract

2004

  • Eilam Gross; DB Kastner; CA Kaiser; Deborah Fass (2004). Structure of Ero1p, source of disulfide bonds for oxidative protein folding in the cell.  Cell. 117:(5)601-610.  Abstract

2003

  • AL Barnett; DL Wensel; WH Li; Deborah Fass; JM Cunningham (2003). Structure and mechanism of a coreceptor for infection by a pathogenic feline retrovirus.  Journal of Virology. 77:(4)2717-2729.  Abstract
  • Deborah Fass (2003). Conformational changes in enveloped virus surface proteins during cell entry.  Virus Structure. 64:325-362.

2002

  • CS Sevier; A Vala; Eilam Gross; Deborah Fass; CA Kaiser (2002). Pathways for the formation and transfer of cellular protein disulfide bonds.  Molecular Biology of the Cell. 13:236A-236A.  Abstract
  • Eilam Gross; CS Sevier; A Vala; CA Kaiser; Deborah Fass (2002). A new FAD-binding fold and intersubunit disulfide shuttle in the thiol oxidase Erv2p.  Nature Structural Biology. 9:(1)61-67.  Abstract

2000

  • Y Paz; Zvulun Elazar; Deborah Fass (2000). Structure of GATE-16, membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7p.  Journal of Biological Chemistry. 275:(33)25445-25450.  Abstract

1999

  • SM Babor; Deborah Fass (1999). Crystal structure of the Sec18p N-terminal domain.  Proceedings of the National Academy of Sciences of the United States of America. 96:(26)14759-14764.  Abstract