Publications

2016

  • Grossman, Iris; Ilani, Tal; Fleishman, Sarel Jacob; Fass, Deborah (2016). Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma.  Protein engineering, design & selection : PEDS. 29.  Abstract
  • Le Zhang, Qing Cheng, Longjie Zhang, Yijun Wang, Gary F. Merrill, Tal Ilani, Deborah Fass, Elias S.J. Arnér, Jinsong Zhang (2016). Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.  Free Radical Biology and Medicine. 99:426–435.
  • Armony, G; Jacob, E; Moran, T; Levin, Y; Mehlman, T; Levy, Y; Fass, D (2016). Cross-linking reveals laminin coiled-coil architecture.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 113:13384-13389.  Abstract

2015

  • Grossman, I; Yuval Aviram, H; Armony, G; Horovitz, A; Hofmann, H; Haran, G; Fass, D (2015). Single-molecule spectroscopy exposes hidden states in an enzymatic electron relay.  Nature communications. 6.  Abstract
  • Moran, T; Gat, Y; Fass, D (2015). Laminin L4 domain structure resembles adhesion modules in ephrin receptor and other transmembrane glycoproteins.  FEBS JOURNAL. 282:2746-2757.  Abstract
  • Kryshtafovych, A., Moult, J., Baslé, A., Burgin, A., Craig, T. K., Edwards, R. A., Fass, D., Hartmann, M. D., Korycinski, M., Lewis, R. J., Lorimer, D., Lupas, A. N., Newman, J., Peat, T. S., Piepenbrink, K. H., Prahlad, J., van Raaij, M. J., Rohwer, F., Segall, A. M., Seguritan, V., Sundberg, E. J., Singh, A. K., Wilson, M. A. and Schwede, T. (2015). Some of the most interesting CASP11 targets through the eyes of their authors.  Proteins.  Abstract
  • Kirchenbuechler, D; Mutsafi, Y; Horowitz, B; Levin-Zaidman, S; Fass, D; Wolf, SG; Elbaum, M (2015). Cryo-STEM Tomography of Intact Vitrified Fibroblasts.  AIMS Biophysics. 2:259-273.  Abstract

2014

  • Kryshtafovych, A; Moult, J; Bales, P; Bazan, JF; Biasini, M; Burgin, A; Chen, C; Cochran, FV; Craig, TK; Das, R; Fass, D; Garcia-Doval, C; Herzberg, O; Lorimer, D; Luecke, H; Ma, XL; Nelson, DC; van Raaij, MJ; Rohwer, F; Segall, A; Seguritan, V; Zeth, K; Schwede, T (2014). Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10.  Proteins-Structure Function And Bioinformatics. 82:26-42.
  • Fass, D; Rittinger, K (2014). Editorial overview: Multi-protein assemblies in signaling.  Current Opinion In Structural Biology. 29:VI-VIII.
  • Gat, Y; Vardi-Kilshtain, A; Grossman, I; Major, DT; Fass, D (2014). Enzyme structure captures four cysteines aligned for disulfide relay.  Protein Science. 23:1102-1112.  Abstract
  • Biran, S; Gat, Y; Fass, D (2014). The Eps1p Protein Disulfide Isomerase Conserves Classic Thioredoxin Superfamily Amino Acid Motifs but Not Their Functional Geometries.  Plos One. 9.  Abstract

2013

  • Limor-Waisberg, K; Ben-Dor, S; Fass, D (2013). Diversification of Quiescin sulfhydryl oxidase in a preserved framework for redox relay.  Bmc Evolutionary Biology. 13.  Abstract
  • Grossman, I; Alon, A; Ilani, T; Fass, D (2013). An Inhibitory Antibody Blocks the First Step in the Dithiol/Disulfide Relay Mechanism of the Enzyme QSOX1.  Journal Of Molecular Biology. 425:4366-4378.  Abstract
  • Ilani, T; Alon, A; Grossman, I; Horowitz, B; Kartvelishvily, E; Cohen, SR; Fass, D (2013). A Secreted Disulfide Catalyst Controls Extracellular Matrix Composition and Function.  Science. 341:74-76.  Abstract
  • Ilani, T; Fass, D (2013). Now at the Met: Fine Art of Reversible Sulfoxidation.  Molecular Cell. 51:281-282.  Abstract

2012

  • Alon, A; Grossman, I; Gat, Y; Kodali, VK; DiMaio, F; Mehlman, T; Haran, G; Baker, D; Thorpe, C; Fass, D (2012). The dynamic disulphide relay of quiescin sulphydryl oxidase.  Nature. 488:414-+.  Abstract
  • Fass, D (2012). Disulfide Bonding in Protein Biophysics.  Annual Review Of Biophysics, Vol 41. 41:63-79.  Abstract
  • Hakim, M; Ezerina, D; Alon, A; Vonshak, O; Fass, D (2012). Exploring ORFan Domains in Giant Viruses: Structure of Mimivirus Sulfhydryl Oxidase R596.  Plos One. 7.  Abstract
  • Limor-Waisberg, K; Alon, A; Mehlman, T; Fass, D (2012). Phylogenetics and enzymology of plant quiescin sulfhydryl oxidase.  Febs Letters. 586:4119-4125.  Abstract

2011

  • DiMaio, F; Terwilliger, TC; Read, RJ; Wlodawer, A; Oberdorfer, G; Wagner, U; Valkov, E; Alon, A; Fass, D; Axelrod, HL; Das, D; Vorobiev, SM; Iwai, H; Pokkuluri, PR; Baker, D (2011). Improved molecular replacement by density- and energy-guided protein structure optimization.  Nature. 473:540-U149.  Abstract
  • Hakim, M; Mandelbaum, A; Fass, D (2011). Structure of a Baculovirus Sulfhydryl Oxidase, a Highly Divergent Member of the Erv Flavoenzyme Family.  Journal Of Virology. 85:9406-9413.  Abstract

2010

  • Blais, JD; Chin, KT; Zito, E; Zhang, YH; Heldman, N; Harding, HP; Fass, D; Thorpe, C; Ron, D (2010). A Small Molecule Inhibitor of Endoplasmic Reticulum Oxidation 1 (ERO1) with Selectively Reversible Thiol Reactivity.  Journal Of Biological Chemistry. 285:20993-21003.  Abstract
  • Alon, A; Heckler, EJ; Thorpe, C; Fass, D (2010). QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains.  Febs Letters. 584:1521-1525.  Abstract
  • Fass, D (2010). Hunting for Alternative Disulfide Bond Formation Pathways: Endoplasmic Reticulum Janitor Turns Professor and Teaches a Lesson.  Molecular Cell. 40:685-686.  Abstract
  • Hakim, M; Fass, D (2010). Cytosolic Disulfide Bond Formation in Cells Infected with Large Nucleocytoplasmic DNA Viruses.  Antioxidants & Redox Signaling. 13:1261-1271.  Abstract
  • Vitu, E; Kim, S; Sevier, CS; Lutzky, O; Heldman, N; Bentzur, M; Unger, T; Yona, M; Kaiser, CA; Fass, D (2010). Oxidative Activity of Yeast Ero1p on Protein Disulfide Isomerase and Related Oxidoreductases of the Endoplasmic Reticulum.  Journal Of Biological Chemistry. 285:18155-18165.  Abstract
  • Heldman, N; Vonshak, O; Sevier, CS; Vitu, E; Mehlman, T; Fass, D (2010). Steps in reductive activation of the disulfide-generating enzyme Ero1p.  Protein Science. 19:1863-1876.  Abstract
  • Kogan, K; Spear, ED; Kaiser, CA; Fass, D (2010). Structural Conservation of Components in the Amino Acid Sensing Branch of the TOR Pathway in Yeast and Mammals.  Journal Of Molecular Biology. 402:388-398.  Abstract

2009

  • Erez, E; Fass, D; Bibi, E (2009). How intramembrane proteases bury hydrolytic reactions in the membrane.  Nature. 459:371-378.  Abstract
  • Farver, O; Vitu, E; Wherland, S; Fass, D; Pecht, I (2009). Electron Transfer Reactivity of the Arabidopsis thaliana Sulfhydryl Oxidase AtErv1.  Journal Of Biological Chemistry. 284:2098-2105.  Abstract
  • Hakim, M; Fass, D (2009). Dimer Interface Migration in a Viral Sulfhydryl Oxidase.  Journal Of Molecular Biology. 391:758-768.  Abstract

2008

  • Bar, M; Celik, Y; Fass, D; Braslavsky, I (2008). Interactions of beta-helical antifreeze protein mutants with ice.  Crystal Growth & Design. 8:2954-2963.  Abstract
  • Portnaya, I; Ben-Shoshan, E; Cogan, U; Khalfin, R; Fass, D; Ramon, O; Danino, D (2008). Self-assembly of bovine beta-casein below the isoelectric pH.  Journal Of Agricultural And Food Chemistry. 56:2192-2198.  Abstract
  • Fass, D (2008). The Erv family of sulfhydryl oxidases.  Biochimica Et Biophysica Acta-Molecular Cell Research. 1783:557-566.  Abstract
  • Vitu, E; Gross, E; Greenblaft, HM; Sevier, CS; Kaiser, CA; Fass, D (2008). Yeast Mpd1p Reveals the Structural Diversity of the Protein Disulfide Isomerase Family.  Journal Of Molecular Biology. 384:631-640.  Abstract
  • Heckler, EJ; Alon, A; Fass, D; Thorpe, C (2008). Human quiescin-sulfhydryl oxidase, QSOX1: Probing internal redox steps by mutagenesis.  Biochemistry. 47:4955-4963.  Abstract
  • Bar, M; Scherf, T; Fass, D (2008). Two-dimensional surface display of functional groups on a beta-helical antifreeze protein scaffold.  Protein Engineering Design & Selection. 21:107-114.  Abstract

2007

  • Ben-Shem, A; Fass, D; Bibi, E (2007). Structural basis for intramembrane proteolysis by rhomboid serine proteases.  Proceedings Of The National Academy Of Sciences Of The United States Of America. 104:462-466.  Abstract
  • Magidovich, E; Orr, I; Fass, D; Abdu, U; Yifrach, O (2007). Intrinsic disorder in the C-terminal domain of the Shaker voltage-activated K+ channel modulates its interaction with scaffold proteins.  Proceedings Of The National Academy Of Sciences Of The United States Of America. 104:13022-13027.  Abstract
  • Sevier, CS; Qu, HJ; Heldman, N; Gross, E; Fass, D; Kaiser, CA (2007). Modulation of cellular disulfide-bond formation and the ER redox environment by feedback-regulation of Ero1.  Cell. 129:333-344.  Abstract
  • Frenkiel-Krispin, D; Wolf, SG; Albeck, S; Unger, T; Peleg, Y; Jacobovitch, J; Michael, Y; Daube, S; Sharon, M; Robinson, CV; Svergun, DI; Fass, D; Tzfira, T; Elbaum, M (2007). Plant transformation by Agrobacterium tumefaciens - Modulation of single-stranded DNA-VirE2 complex assembly by VirE1.  Journal Of Biological Chemistry. 282:3458-3464.  Abstract

2006

  • Gross, E; Sevier, CS; Heldman, N; Vitu, E; Bentzur, M; Kaiser, CA; Thorpe, C; Fass, D (2006). Generating disulfides enzymatically: Reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p.  Proceedings Of The National Academy Of Sciences Of The United States Of America. 103:299-304.  Abstract
  • Sirkis, R; Gerst, JE; Fass, D (2006). Ddi1, a eukaryotic protein with the retroviral protease fold.  Journal Of Molecular Biology. 364:376-387.  Abstract
  • Vitu, E; Bentzur, M; Lisowsky, T; Kaiser, CA; Fass, D (2006). Gain of function in an ERV/ALR sulfhydryl oxidase by molecular engineering of the shuttle disulfide.  Journal Of Molecular Biology. 362:89-101.  Abstract
  • Bar, M; Bar-Ziv, R; Scherf, T; Fass, D (2006). Efficient production of a folded and functional, highly disulfide-bonded beta-helix antifreeze protein in bacteria.  Protein Expression And Purification. 48:243-252.  Abstract

2005

  • Sevier, CS; Kadokura, H; Tam, VC; Beckwith, J; Fass, D; Kaiser, CA (2005). The prokaryotic enzyme DsbB may share key structural features with eukaryotic disulfide bond forming oxidoreductases.  Protein Science. 14:1630-1642.  Abstract
  • Forster, F; Medalia, O; Zauberman, N; Baumeister, W; Fass, D (2005). Retrovirus envelope protein complex structure in situ studied by cryo-electron tomography.  Proceedings Of The National Academy Of Sciences Of The United States Of America. 102:4729-4734.  Abstract

2004

  • Gross, E; Kastner, DB; Kaiser, CA; Fass, D (2004). Structure of Ero1p, source of disulfide bonds for oxidative protein folding in the cell.  Cell. 117:601-610.  Abstract

2003

  • Barnett, AL; Wensel, DL; Li, WH; Fass, D; Cunningham, JM (2003). Structure and mechanism of a coreceptor for infection by a pathogenic feline retrovirus.  Journal Of Virology. 77:2717-2729.  Abstract
  • Fass, D (2003). Conformational changes in enveloped virus surface proteins during cell entry.  Virus Structure. 64:325-362.

2002

  • Gross, E; Sevier, CS; Vala, A; Kaiser, CA; Fass, D (2002). A new FAD-binding fold and intersubunit disulfide shuttle in the thiol oxidase Erv2p.  Nature Structural Biology. 9:61-67.  Abstract
  • Sevier, CS; Vala, A; Gross, E; Fass, D; Kaiser, CA (2002). Pathways for the formation and transfer of cellular protein disulfide bonds.  Molecular Biology Of The Cell. 13:236A.

2000

  • Paz, Y; Elazar, Z; Fass, D (2000). Structure of GATE-16, membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7p.  Journal Of Biological Chemistry. 275:25445-25450.  Abstract

1999

  • Babor, SM; Fass, D (1999). Crystal structure of the Sec18p N-terminal domain.  Proceedings Of The National Academy Of Sciences Of The United States Of America. 96:14759-14764.  Abstract