Our lab studies enzymes that catalyze the formation of disulfide bonds during protein folding and assembly. Our research combines structural and molecular biology with experiments in vivo, allowing us to determine how catalysts of disulfide bonding contribute to animal physiology and, in certain cases, pathology. Controlling the activities of disulfide catalysts may have applications in medicine and tissue engineering, an avenue we are pursuing through the design of specific inhibitors of these enzymes (see movie).