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May 01-31, 2016
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Date:25WednesdayMay 2016Lecture
Sexually dimorphic neuronal connectivity established by sex-specific synapse pruning in C. elegans
More information Time 14:00 - 15:00Location Raoul and Graziella de Picciotto Building for Scientific and Technical Support
LobbyLecturer Dr. Meital Oren-Suissa
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NYOrganizer Department of Immunology and Regenerative BiologyContact -
Date:26ThursdayMay 2016Lecture
Magnetic Resonance Seminar
More information Time 09:30Title Magnetic Molecular Beams - a non-conventional approach for hyper sensitive NMRLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Gil Alexandrowicz
Schulich Faculty of Chemistry, TechnionOrganizer Department of Chemical and Biological PhysicsContact -
Date:26ThursdayMay 2016Colloquia
Exploring Flatland
More information Time 11:15 - 12:30Location Edna and K.B. Weissman Building of Physical Sciences
AuditoriumLecturer Andre Geim
ManchesterOrganizer Faculty of PhysicsContact Details Show full text description of 11:00 – coffee, tea, and more...» 11:00 – coffee, tea, and moreAbstract Show full text abstract about Following the advent of graphene, many other one-atom or one...» Following the advent of graphene, many other one-atom or one-molecule thick crystals have been isolated and investigated. These two-dimensional crystals have become one of the hottest topics in materials science and condensed matter physics. Furthermore, isolated atomic planes can now be reassembled back into three-dimensional structures and crystals made layer by layer in a designer sequence. I will provide a brief, lowbrow introduction to graphene, trying to explain why this material has attracted so much attention, and then overview our progress in making new assemblies from available atomic planes in order to illustrate how rich in phenomena and application this research field is. -
Date:26ThursdayMay 2016Lecture
Single-molecule views of eukaryotic DNA mismatch repair
More information Time 14:00Location Helen and Milton A. Kimmelman Building
Dov Elad RoomLecturer Prof. Ilya Finkelstein
Department of Molecular Biosciences & ICMB University of Texas at AustinOrganizer Department of Chemical and Structural BiologyContact -
Date:27FridayMay 2016Cultural Events
Nathan's Friends - Argentine tango
More information Time 20:00Location Michael and Anna Wix AuditoriumContact -
Date:28SaturdayMay 2016Cultural Events
"Set el chbayeb Ima" - Iraqi show
More information Time 20:30 - 22:00Location Michael and Anna Wix AuditoriumContact -
Date:29SundayMay 201610FridayJune 2016Conference
Cosmological Probes of Fundamental Physics
More information Time All dayLocation Edna and K.B. Weissman Building of Physical SciencesChairperson Kfir BlumContact -
Date:29SundayMay 2016Lecture
G-INCPM-Special Seminar - Yael Malkinson Weiss, MD PhD, Executive Director Business Development, Ultragenyx Pharmaceutical, Novato CA - "Developing therapies for rare genetic diseases: weighing traditional versus novel therapeutic modalities"
More information Time 11:00 - 12:30Location Nancy and Stephen Grand Israel National Center for Personalized Medicine
AuditoriumLecturer Yael Malkinson Weiss, MD PhD
Executive Director Business Development, Ultragenyx Pharmaceutical, Novato CAOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Developing therapies for the treatment of rare genetic disea...» Developing therapies for the treatment of rare genetic disease is frequently perceived to be simpler and with a lower risk than that associated with larger indications. This perception stems from the fact that many of these are monogenic, with predictable genetic effects and clear mechanisms, thus it should be straightforward to replace the defective protein. Since the diseases are usually severe the benefit is large, and in many cases, the rarer the disease, the smaller the clinical trials that are required for registration are.
However, there are over 7,000 genetic diseases with an even larger number of genes affected. The initial approach of protein replacement therapies can be successful but is limited to a relatively small diseases in which the defective proteins are localized in a subset of cellular organelles to which therapeutic proteins will naturally target (lysosome for example). Most of the diseases treatable with traditional protein replacement are becoming very crowded for how small the treatable patient population is. Thus - other solutions need to be considered for the thousands of diseases for which direct proteins replacement is not a viable approach.
Ultragenyx is a biotech company focused on development of therapies for rare genetic diseases. The company’s approach to building its pipeline and deciding how and when to include traditional (protein replacement therapies, small molecules) or new (nucleic acid based therapies) therapeutic modalities will be presented and examples will be discussed.
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Date:29SundayMay 2016Lecture
The ins and outs of subaerial lithotrophic biofilm in arid and hyper-arid environments
More information Time 11:00Location Sussman Family Building for Environmental Sciences
M. Magaritz Seminar RoomLecturer Nimrod Wieler
Department of Environmental Hydrology & Microbiology Ben-Gurion University of the NegevOrganizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about Rock surfaces support microbial communities that may be invo...» Rock surfaces support microbial communities that may be involved in weathering processes. In arid and hyper-arid environments microbes dominate rock surfaces and were linked to weathering because the scarcity of water excludes classical mechanisms that erode rocks. We studied subaerial biofilms coating arid rocks, focusing on sedimentary rocks that feature comparable weathering morphologies but different lithologies. We hypothesized that weathering is fashioned by salt erosion and mediated by biofilms that play dual roles: stabilizing the rock surfaces by coating, and enhancing salt crystallization by preventing rapid desiccation (thus mitigating and facilitating erosion processes, respectively). We used a combination of microbial and geological techniques to characterize the rocks morphologies and their subaerial biofilms. Deep sequencing and microscopy analyses suggest that bacterial diversity is low, dominated by Proteobacteria, Cyanobacteria and Actinobacteria. Together these phyla formed laminar biofilms that secrete extracellular polymeric substances to aggregate microfabrics and mitigate desiccation, reducing water loss by over 40%. The biofilm was detected only in rocks exposed to the atmosphere, present distinct architecture and burrowed up to 9 mm beneath the surface, protected by sedimentary deposits. A closer inspection revealed that the composition of the biofilm was tightly linked to dust bacterial communities but distinct from soil communities. Moreover, the biofilm composition changed according to the rock location rather than its’ lithology, suggesting that microclimate (dew, relative humidity and radiation) play an important role in arid weathering. Our results contradict common dogmas that considered biofilms as degrading agents and propose their role as mitigators of geomorphic processes.
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Date:29SundayMay 2016Lecture
A systematic view on Influenza induced host shut-off
More information Time 13:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Julie Tai
Noam Stern-Ginossar's group, Dept. of Molecular Genetics, WISOrganizer Department of Molecular GeneticsContact -
Date:29SundayMay 2016Lecture
The Simple Physics Behind Energy Use
More information Time 13:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Peter Rez
Department of Physics, Arizona State University, USAOrganizer Feinberg Graduate School
Alternative Sustainable Energy Research Initiative (AERI)Contact Details Show full text description of Gathering & refreshments at 12:40...» Gathering & refreshments at 12:40 -
Date:29SundayMay 2016Lecture
Quantitative investigation of birdsong: from learning to performance
More information Time 13:00Location Dannie N. Heineman Laboratory
Drory AuditoriumLecturer Prof. Ofer Tchernichovski
Department of Psychology Hunter College, NYCOrganizer Clore Center for Biological Physics
Biological Physics GroupContact Details Show full text description of Sandwiches at 12:45...» Sandwiches at 12:45Abstract Show full text abstract about • Music maintains a characteristic balance between repetitio...» • Music maintains a characteristic balance between repetition and novelty. I will present evidence for a similar balance in singing performances of free-living Australian pied butcherbirds.
• While acquiring motor skills, such as courtship songs and dances, animals must match their performance to a desired target. However, because both the structure and the temporal position of individual gestures are adjustable, the number of possible motor transformations increases exponentially with sequence length, and searching for the optimal transformation quickly becomes computationally intractable. We show how zebra finches cope with the computational complexity of song learning.
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Date:29SundayMay 2016Lecture
Antihydrogen - a tool to study matter-antimatter symmetry in the laboratory
More information Time 14:00Location Edna and K.B. Weissman Building of Physical Sciences
Drory AuditoriumLecturer Eberhard Widmann
President of the Austrian Physical Society Director, Stefan Meyer Institute for Subatomic Physics, Austrian Academy of SciencesOrganizer Department of Particle Physics and Astrophysics
Special SeminarContact Abstract Show full text abstract about Antihydrogen, the bound state of an antiproton and a positro...» Antihydrogen, the bound state of an antiproton and a positron, is the simplest atom consisting purely of antimatter. Its matter counterpart, hydrogen, is one of the best studied atomic systems in physics. Thus comparing the spectra of hydrogen and antihydrogen offers some of the most sensitive tests of matter-antimatter symmetry. Furthermore, the availability of neutral antimatter offers for the first time a precise measurement of its gravitational interaction that was so far not possible due to the dominance of the electro-magnetic interaction for charged antiparticles.
The formation and experimental investigation of antihydrogen is the main physics goal of several col-laborations at the Antiproton Decelerator of CERN. The ASACUSA collaboration is pursuing a meas-urement of the ground-state hyperfine structure of antihydrogen in an atomic beam, a quantity which was measured in hydrogen using a maser to a relative precision of 10^{-12}. The AEgIS collaboration aims at using an ultra-cold beam of antihydrogen atoms and a classical moiré deflectometer to determine the gravitational interaction between matter and antimatter in a first step to percent level precision.
After a first production of cold antihydrogen in 2002 and a first trapping in 2010 the experiments are still in the process of optimizing the antihydrogen production from trapped antiprotons and positrons. The status and prospect of these experiments will be reviewed.
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Date:29SundayMay 2016Lecture
Unraveling unconventional role for astroglial connexins in synaptic strength and memory
More information Time 15:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Nathalie Rouach
CIRB, College de France, ParisOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Astrocytes play active roles in brain physiology by dynamic ...» Astrocytes play active roles in brain physiology by dynamic interactions with neurons. Connexin 30, one of the two main astroglial gap-junction subunits, is thought to be involved in behavioral and basic cognitive processes. However, the underlying cellular and molecular mechanisms were unknown. We will show here in mice that connexin 30 controls hippocampal excitatory synaptic transmission through modulation of astroglial glutamate transport, which directly alters synaptic glutamate levels. Unexpectedly, we found that connexin 30 regulated cell adhesion and migration and that connexin 30 modulation of glutamate transport, occurring independently of its channel function, was mediated by morphological changes controlling insertion of astroglial processes into synaptic clefts. By setting excitatory synaptic strength, connexin 30 plays an important role in long-term synaptic plasticity and in hippocampus-based contextual memory. Taken together, these results establish connexin 30 as a critical regulator of synaptic strength by controlling the synaptic location of astroglial processes.
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Date:29SundayMay 2016Lecture
Braginsky Center for the Interface between the Sciences and the Humanities
More information Time 15:30Title Back to the Future: Recovering “The Age of Wonder”Location Dolfi and Lola Ebner AuditoriumLecturer Prof. David K. Campbell
Boston UniversityOrganizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about In his remarkable and inspiring book “The Age of Wonder,” Ri...» In his remarkable and inspiring book “The Age of Wonder,” Richard Holmes describes the synergistic links between the sciences and humanities among (in particular) the English intellectuals in the period 1770-1830. “Natural philosophers” like Sir Humphrey Davy had regular interactions with poets like Samuel Taylor Coleridge, and authors like Mary Shelly wrote of dystopias that could result from the misapplication of science and technology. Modern intellectuals, contemplating the current clearly apparent divide between the humanities and the sciences, tend to look at this “age of wonder” through rose-colored glasses and to long for its return. But is this yearning realistic? In our increasingly complex and specialized world, can we truly expect to recover the close bond between these distinct ways of knowing the world? Can we construct an interdisciplinary technological humanism that meaningfully links the sciences and the humanities?
In this talk I attempt to provide limited and subjective answers to these questions and to describe general developments and trends that I believe may give hope that we can indeed recover the “age of wonder.”
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Date:30MondayMay 2016Lecture
Multi-level scalable proteomic interrogation of intact biological systems
More information Time 10:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Prof. Kwanghun Chung
Department of Chemical Engineering Institute for Medical Engineering and Science (IMES)Picower Institute for Learning and Memory Massachusetts Institute of Technology http://www.chunglab.org/Organizer Department of Brain SciencesContact Details Show full text description of Lecture co-hosted by the Neurobiology Department and the Opt...» Lecture co-hosted by the Neurobiology Department and the Optical Imaging Club -
Date:30MondayMay 2016Colloquia
"Chemical Publishing in the 21st Century:Perspectives of a JACS Editor"
More information Time 11:00 - 12:15Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Peter Stang
Department of Chemistry, University of UtahOrganizer Faculty of ChemistryContact -
Date:30MondayMay 2016Lecture
The diphoton excess at the LHC
More information Time 11:00Location Edna and K.B. Weissman Building of Physical Sciences
Drory AuditoriumLecturer Liron Barak
CERNOrganizer Department of Particle Physics and Astrophysics
Special SeminarContact Abstract Show full text abstract about “Early results from the Run-II of the Large Hadron Collider ...» “Early results from the Run-II of the Large Hadron Collider were recently presented by the ATLAS and CMS experiments. They show hints of an excess in the diphoton mass spectrum near 750 GeV. While these hints might turn out to be statistical fluctuations, they could also be first indications of physics beyond the Standard Model. I will explain in detail the experimental procedures that led to these exciting results. I will further describe the strategy in which we intend to investigate this excess in the near future and either reject or confirm the discovery of new physics.” -
Date:30MondayMay 2016Lecture
Active DNA Demethylation in Development and Cancer
More information Time 12:00 - 13:30Location Camelia Botnar Building
AuditoriumLecturer Prof. Alfonso Bellacosa
Cancer Epigenetics and Cancer Biology Programs, Fox Chase Cancer Center, Philadelphia USAOrganizer Department of Biomolecular SciencesContact -
Date:30MondayMay 2016Lecture
Geometric Heat Engines Without Power-Efficiency Tradeoff
More information Time 14:15Location Edna and K.B. Weissman Building of Physical Sciences
Room ALecturer OREN RAZ
UNIVERSITY OF MARYLANDOrganizer Department of Physics of Complex Systems
Statistical Physics SeminarContact Abstract Show full text abstract about Thermodynamics places a limit on the efficiency of heat engi...» Thermodynamics places a limit on the efficiency of heat engines, but not on their output power or on how the power and efficiency change with the engine’s cycle time. In the talk I will present a geometrical description of the power and efficiency as a function of the cycle time, applicable to an important class of heat engine models. This geometrical description is used to design engine protocols that attain both the maximal power and maximal efficiency at the fast driving limit. Furthermore, using this method, we also prove that no protocol can exactly attain the Carnot efficiency at nonzero power.
Ref: PRL 116, 160601 (2016)