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Prof. Yosef Yarden
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Breast cancer is a heterogeneous group of diseases, traditionally distinguished based on the
expression levels of three key receptors: Estrogen receptor, progesterone receptor and Her2.
However extensive mRNA expression studies, and genomic studies show higher complexity of
classification and can further subdivide the tumors. In our work, we apply mass spectrometry-based
proteomics analysis and challenge the existing classification. Furthermore, we analyze the internal
tumor heterogeneity by dividing the tumors according to their histopathological parameters, and
identify the diversity of proteomic profiles within single tumors. Altogether, the proteomic approach
was able to unravel hidden layers within this complex disease.