Biophysical principles of mutagenesis

Mutations drive evolution, account for genetic variants in the population, and are the primary cause of cancer and other genetic disorders.

The lack of a deep molecular understanding of the biochemical processes that generate mutations (e.g., DNA lesion recognition) limits our ability to better understand and ultimately treat and prevent genetic diseases.

In our lab, we study and characterize in an unprecedented scope, the biophysical principles behind the such process.