Low-FODMAP Diet in Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a highly prevalent symptomatic disorder that affects 10% of the population – causing frequent diarrhea and/or constipation accompanied by intense abdominal pain. Today, the best option to treat symptoms of IBS patients is to conduct an elimination diet called “a low-FODMAP diet” – which achieves first-rate symptom improvement. The concept behind this dietary regime is to eliminate molecules that are highly fermented by gut bacteria and reduce the fermentation products they produce and their overall activity. We aim to characterize the gut microbiome of healthy individuals and IBS patients and to uncover the mechanisms that might mediate symptom recovery.